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Novel cardiovascular prosthetic devices or implants having many useful cardiovascular applications comprise a porous surface and a network of interconnected interstitial pores below the surface in fluid flow communication with the surface pores. Tissue forms a smooth thin adherent coating of self-de

Novel cardiovascular prosthetic devices or implants having many useful cardiovascular applications comprise a porous surface and a network of interconnected interstitial pores below the surface in fluid flow communication with the surface pores. Tissue forms a smooth thin adherent coating of self-determining thickness on the porous surface making it resistant to the formation of the blood clots normally associated with the presence of foreign bodies in the blood stream. The device has particular utility in heart valves, pacemaker electrodes, blood pumps, blood stream filters, an artificial pancreas, vascular access tubes, small and large bore vascular grafts, blood pump diaphragms and vascular and intracardiac patches.

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A method of forming a small bore flexible vascular graft constructed of flexible biocompatible polymeric material, which comprises: (a) uniformly dispersing solvent-elutable particles dimensioned to provide a pore size of less than about 50 microns in the graft in a continuous or discontinuous polym

A method of forming a small bore flexible vascular graft constructed of flexible biocompatible polymeric material, which comprises: (a) uniformly dispersing solvent-elutable particles dimensioned to provide a pore size of less than about 50 microns in the graft in a continuous or discontinuous polymer phase in a quantity sufficient to establish a porosity of about 10 to about 70% by volume in the graft, (b) forming a coherent shaped tubular article having an inside diameter of from about 2 to about 6 mm from the dispersion wherein the solvent-elutable particles are substantially uniformly dispersed throughout a continuous solid phase tubular article in intraparticulate contacting relationship, and (c) eluting the solvent-elutable particles from the tubular article using a solvent for said particles to provide a porous tubular product suitable for use as a vascular graft and having a subsurface regions comprising a network of interconnected pores substantially uniformly distributed therein, porous inner and outer surfaces communicating with said subsurface, a pore size of less than about 50 microns and a porosity of about 10 to about 70% by volume.