초록 ▼

A cationic charge modified microporous membrane, process for producing said membrane and use thereof are provided. The membrane comprises a hydrophilic organic polymeric microporous membrane and a charge modifying amount of a primary cationic charge modifying agent bonded to substantially all of the

A cationic charge modified microporous membrane, process for producing said membrane and use thereof are provided. The membrane comprises a hydrophilic organic polymeric microporous membrane and a charge modifying amount of a primary cationic charge modifying agent bonded to substantially all of the wetted surfaces of the membrane. The primary charge modifying agent if a water soluble organic polymer having a molecular weight greater than about 1000 wherein each monomer thereof has at least one epoxide group capable of bonding to the surface of the membrane and at least one tertiary amine or quaternary ammonium group. Preferably, a portion of the epoxy groups on the organic polymer are bonded to a secondary charge modifying agent selected from the group consisting of: (i) aliphatic amines having at least one primary amine or at least two secondary amines; and (ii) aliphatic amines having at least one secondary amine and a carboxyl or hydroxyl substituent. The charge modified microporous membrane of this invention may be used for the filtration of fluids, particularly parenteral or biological liquids. The membrane has low extractables and is sanitizable or sterilizable.

대표청구항 ▼

A process for the filtration of a liquid having particulate contaminants therein comprising passing the liquid through a symmetrical, isotropic porous hydrophilic cationic charge modified microporous filter membrane comprising: a symmetrical, isotropic porous hydrophilic organic polymeric microporou

A process for the filtration of a liquid having particulate contaminants therein comprising passing the liquid through a symmetrical, isotropic porous hydrophilic cationic charge modified microporous filter membrane comprising: a symmetrical, isotropic porous hydrophilic organic polymeric microporous filter membrane having a microstructure throughout said membrane and a pore size of at least 0.05 microns; and a charge modifying amount of a primary charge modifying agent bonded to substantially all of said membrane microstructure, without substantial pore size reduction or pore blockage, wherein the primary charge modifying agent is a water soluble organic polymer having a molecular weight greater than about 1000, wherein each monomer thereof has at least one epoxide group capable of bonding to the microstructure of the membrane and each monomer thereof has at least one tertiary amine or quaternary ammonium group, whereby the contaminants are removed from the liquid by retention by said cationic charge modified membrane.