초록 ▼

Surgical implants, especially endoprosthetic orthopaedic implants and sutures, are rendered antimicrobial by the presence of a bioerodible metallic silver component, especially a surface coating, which provides in vivo a sustained release of silver ions in a concentration sufficient to provide a loc

Surgical implants, especially endoprosthetic orthopaedic implants and sutures, are rendered antimicrobial by the presence of a bioerodible metallic silver component, especially a surface coating, which provides in vivo a sustained release of silver ions in a concentration sufficient to provide a localized antimicrobial effect but insufficient to cause significant damage to connective tissue. Latently bioerodible silver components of an implant can be activated by, for example, abrasion, heating to above about 180°C. or, especially, contact with hydrogen peroxide.

대표청구항 ▼

An endoprosthetic implant comprising a permanent implant structure formed of a substantially bioinert structural material providing permanent mechanical integrity to the implant, wherein a bioerodible metallic silver component is deposited to form a surface coating 25 to 500 Angstroms in thickness o

An endoprosthetic implant comprising a permanent implant structure formed of a substantially bioinert structural material providing permanent mechanical integrity to the implant, wherein a bioerodible metallic silver component is deposited to form a surface coating 25 to 500 Angstroms in thickness on said permanent implant structure and provides in vivo a sustained release of silver ions in a concentration sufficient to provide a localized anti-microbial effect but insufficient to cause significant damage to connective tissue.