초록 ▼

This invention provides for the production of microspheres in an oil-in-water emulsion process using an emulsifier, whereby solvent removal from the oil phase allows for isolation of discrete microspheres, wherein the release rate of a core material is modified by the use of an alkaline agent, e.g.

This invention provides for the production of microspheres in an oil-in-water emulsion process using an emulsifier, whereby solvent removal from the oil phase allows for isolation of discrete microspheres, wherein the release rate of a core material is modified by the use of an alkaline agent, e.g. sodium hydroxide, during the preparation of the microspheres.

대표청구항 ▼

In a process for the preparation of microspheres having a particulate core material encapsulated by a polymer coating wherein the polymer is dissolved in a volatile water-immiscible solvent in which the core material is not soluble, adding the core material particles, mixing the resulting dispersion

In a process for the preparation of microspheres having a particulate core material encapsulated by a polymer coating wherein the polymer is dissolved in a volatile water-immiscible solvent in which the core material is not soluble, adding the core material particles, mixing the resulting dispersion with an aqueous emulsifier solution to form an oil-in-water emulsion, and removing the solvent to form discrete microcapsules, the improvement which comprises adding from about 0.5 to about 20 percent based on the weight of the polymer of a basic inorganic salt, an alkaline buffer solution or an organic amine as an alkaline agent to a sodium oleate, potassium oleate, or polyvinyl alcohol aqueous emulsifier solution for mixing with the dispersion, wherein the alkaline agent modifies the release rate of the core material from the microcapsules. In a process for the preparation of microspheres having a homogeneous mixture of polymer and core material wherein both the polymer and core material are dissolved in a volatile, water immiscible solvent, mixing the polymer-core material-solvent system with an aqueous emulsifier solution to form an oil-in-water emulsion and removing the solvent to form discrete microprills, the improvement which comprises adding from about 0.5 to about 20 percent based on the weight of the polymer of a basic inorganic salt, an alkaline buffer solution or an organic amine as in alkaline agent to a sodium oleate, potassium oleate, or polyvinyl alcohol aqueous emulsifier solution for mixing with the polymer-core material-solvent system, wherein the alkaline agent modifies the release rate of the core material from the microcapsules.