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Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-033/54
출원번호 US-0495621 (1983-05-18)
발명자 / 주소
  • Craig Alan R. (Wilmington DE) Frey William A. (Wilmington DE) Leflar Charles C. (Wilmington DE) Looney Catharine E. (Wilmington DE) Luddy Michael A. G. (West Chester PA)
출원인 / 주소
  • E. I. Du Pont de Nemours and Company (Wilmington DE 02)
인용정보 피인용 횟수 : 76  인용 특허 : 8

초록

Novel particle reagents for light scattering immunoassays are provided. The particle reagents are high refractive index shell-core polymers covalently bonded to compounds of biological interest or analogs thereof. A method of measuring unknown concentrations of these compounds of biological interest

대표청구항

A method for measuring compounds of biological interest comprising the steps of (A) incubating (1) a particle reagent having high refractive index consisting essentially of: (a) a polymer particle having an inner core and an outer shell wherein the inner core is a polymer having a refractive index o

이 특허에 인용된 특허 (8)

  1. Craig Alan R. (Wilmington DE) Frey William A. (Wilmington DE) Leflar Charles C. (Wilmington DE) Looney Catharine E. (Wilmington DE) Luddy Michael A. (West Chester PA), Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays.
  2. Johnson Lavell R. (Salt Lake City UT), Immobilized immunoadsorbent.
  3. Fischer Ernst A. (Mnchenstein CHX), Immunological diagnostic reagents.
  4. Roncari Gaetano (Ettingen CHX), Immunological diagnostic reagents comprising thio-amine terminated latex particles.
  5. Daniel Jean-Claude (Fontenay-sous-Bois FR), Latex of styrene polymers with terminal amino-sulfonated groups and method of making.
  6. Dorman Linneaus C. (Midland MI) Mani Inder (Midland MI), Method of coupling a protein to an epoxylated latex.
  7. Fischer Ernst A. (Munchenstein CHX), Process for producing immunological diagnostic reagents.
  8. Hales Richard H. (West Jordan UT), Supported receptor and use thereof in an assay.

이 특허를 인용한 특허 (76)

  1. Yguerabide Juan ; Yguerabide Evangelina E. ; Kohne David E. ; Jackson Jeffrey T., Analyte assay using particulate labels.
  2. Yguerabide, Juan; Yguerabide, Evangelina E.; Kohne, David E.; Jackson, Jeffrey T., Analyte assay using particulate labels.
  3. Leland Jonathan K. ; Shah Haresh P. ; Kenten John Henry ; Goodman Jack E. ; Lowke George E. ; Namba Yuzaburo,JPX ; Blackburn Gary F. ; Massey Richard J., Apparatus for improved luminescence assays.
  4. Massey Richard J. ; Blackburn Gary F. ; Wilkins Elizabeth W. ; Leland Jonathan K., Apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence.
  5. Yang, Kaiyuan; Wei, Ning; Kaylor, Rosann; Chidebelu-Eze, Chibueze Obinna; Atanassov, Zdravko Savov, Assay devices that utilize hollow particles.
  6. Cohen, David; Kaylor, Rosann; Sayre, Curtis, Biomolecule diagnostic device.
  7. Sayre, Curtis; Cohen, David; Kaylor, Rosann, Biomolecule diagnostic devices.
  8. Sayre,Curtis; Cohen,David; Kaylor,Rosann, Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices.
  9. Wang Chengrong (Hockessin DE), Carbamazepine derivatives.
  10. Wang Chengrong, Carbamazepine derivatives used in particle reagents.
  11. Wang Chengrong, Carbamazepine derivatives/antigens.
  12. Fitzpatrick Judith ; Lenda Regina B., Chromatographic immunoassay device and method utilizing particle valency for quantification.
  13. Yang, Jihong; Quarmby, Valerie Elizabeth, Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule.
  14. Sundrehagen, Erling, Determination method for calprotectin and the use of calprotectin as a predictive marker for cardiovascular disease.
  15. Cohen,David; Kaylor,Rosann, Diffraction-based diagnostic devices.
  16. Cohen,David; Kaylor,Rosann, Diffraction-based diagnostic devices.
  17. Cohen,David; Kaylor,Rosann, Diffraction-based diagnostic devices.
  18. Kaylor,Rosann; Cohen,David; Sayre,Curtis, Diffraction-based diagnostic devices.
  19. Sayre,Curtis; Kaylor,Rosann; Cohen,David, Diffraction-based diagnostic devices.
  20. Leland, John K.; Shah, Haresh P.; Kenten, John H.; Goodman, Jack E.; Lowke, George E.; Namba, Yuzaburo; Blackburn, Gary F.; Massey, Richard J., Electrochemiluminescent localizable complexes for assay compositions.
  21. Bard, Allen J.; Liu, Chong-Yang, Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode.
  22. Bard, Allen J.; Liu, Chong-Yang, Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode.
  23. Bard, Allen J.; Liu, Chong-Yang, Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode.
  24. Cohen, David Samuel, Electroluminescent illumination source for optical detection systems.
  25. Orton, Matthew J.; Mastromattei, Robert; O'Connell, Robert; Schmidt, Richard C.; Reitz, Graham, Electromagnetically actuated multi-leaf collimator.
  26. Boga,Rameshbabu; Chidebelu Eze,Chibueze Obinna; Kaylor,Rosann M.; Song,Xuedong, Enhanced diffraction-based biosensor devices.
  27. Song,Xuedong; Kaylor,Rosann; Feaster,Shawn; Yang,Kaiyuan, Fluidics-based assay devices.
  28. Craig Alan R. (Wilmington DE) Gorman Eileen G. (Wilmington DE), High refractive index haloalkyl-functional shell-core polymers and their use in light scattering immunoassays.
  29. Chu,Victor P.; Teng,Zhu; Lewisch,Sandra; Edwards,Ronald L., Lidocaine analogs and methods of making and using same.
  30. Hansen W. Peter ; Cennerazzo Michael ; Edens Carl Theodore ; Kochar Manish, Light scatter-based immunoassay.
  31. Song, Xuedong; Kaylor, Rosann Marie Matthews, Membrane-based assay devices.
  32. Song,Xuedong; Kaylor,Rosann, Membrane-based assay devices.
  33. Song, Xuedong; Kaylor, Rosann; Knotts, Michael; Wei, Ning, Membrane-based assay devices that utilize time-resolved fluorescence.
  34. Song, Xuedong, Membrane-based lateral flow assay devices that utilize phosphorescent detection.
  35. Song, Xuedong, Membrane-based lateral flow assay devices that utilize phosphorescent detection.
  36. Lu, Weiguo; Ruchala, Kenneth J.; Olivera, Gustavo H.; Schnarr, Eric; Kapatoes, Jeffrey M.; Mackie, Thomas R.; Reckwerdt, Paul J., Method and system for adapting a radiation therapy treatment plan based on a biological model.
  37. Ruchala, Kenneth J.; Olivera, Gustavo H.; Lu, Weiguo; Schnarr, Eric; Haimerl, Jason; Mackie, Thomas R.; Kapatoes, Jeffrey M., Method and system for evaluating delivered dose.
  38. Fordyce, II, Gerald D.; Ruchala, Kenneth J.; Schnarr, Eric; Chen, Yu; Reitz, Graham T.; Finley, Scott; O'Connell, Rob; Orton, Matthew, Method and system for evaluating quality assurance criteria in delivery of a treatment plan.
  39. Lu, Weiguo; Olivera, Gustavo H.; Kapatoes, Jeffrey M.; Ruchala, Kenneth J.; Schnarr, Eric; Hughes, John H.; Mackie, Thomas R.; Reckwerdt, Paul J., Method and system for evaluating quality assurance criteria in delivery of a treatment plan.
  40. Schnarr, Eric; Ruchala, Kenneth J.; Olivera, Gustavo H.; Lu, Weiguo; Kapatoes, Jeffrey M.; Haimerl, Jason; Hughes, John H.; Mackie, Thomas R., Method and system for processing data relating to a radiation therapy treatment plan.
  41. Vunnam Ranga R. (New City NY) Leong Koon-wah (Ossining NY) Raimondo Oscar (Flushing NY) Fernandez Jose I. (Jackson Heights NY), Method for coupling antibody to novel latex substrate and its use in immunoassay.
  42. Song, Xuedong, Method for extending the dynamic detection range of assay devices.
  43. Wang Chengrong, Method for making carbamazephine derivative.
  44. Wang Chengrong, Method for measuring carbamazepine in human serum.
  45. Cohen, David; Kaylor, Rosann; Sayre, Curtis, Method for producing biomolecule diagnostic devices.
  46. Olivera, Gustavo H.; Ruchala, Kenneth J.; Schnarr, Eric; Kapatoes, Jeffrey M.; Lu, Weiguo; Haimerl, Jason; Hughes, John H.; Mackie, Thomas R., Method of and system for predicting dose delivery.
  47. Lu, Weiguo; Olivera, Gustavo H.; Ruchala, Kenneth J.; Schnarr, Eric, Method of placing constraints on a deformation map and system for implementing same.
  48. Wei, Ning, Method of reducing the sensitivity of assay devices.
  49. von der Eltz, Herbert; Arabshahi, Lili; Li, Haijuan; Huber, Erasmus, Method, assay, and kit for quantifying HIV protease inhibitors.
  50. Leland John K. ; Shah Haresh P. ; Kenten John H. ; Goodman Jack E. ; Lowke George E. ; Namba Yuzaburo,JPX ; Blackburn Gary F. ; Massey Richard J., Methods and apparatus for improved luminescence assays.
  51. Leland Jonathan K. ; Shah Haresh P. ; Kenten John H. ; Goodman Jack E. ; Lowke George E. ; Blackburn Gary F. ; Massey Richard J., Methods and apparatus for improved luminescence assays.
  52. Massey Richard J. ; Blackburn Gary F. ; Wilkins Elizabeth W. ; Leland Jonathan K., Methods and apparatus for improved luminescence assays using particle concentration, electrochemical generation of chem.
  53. Dahlb채ck,Bj철rn, Methods and reagents for determining protein S.
  54. Leland John K. ; Shah Haresh P. ; Kenten John H. ; Goodman Jack E. ; Lowke George E. ; Namba Yuzaburo,JPX ; Blackburn Gary F. ; Massey Richard J., Methods for improved particle electrochemiluminescence assays.
  55. Yguerabide,Juan; Yguerabide,Evangelina; Warden,Laurence; Peterson,Todd, Methods for providing extended dynamic range in analyte assays.
  56. Yang, Kaiyuan; Wei, Ning; Kaylor, Rosann; Chidebelu-Eze, Chibueze Obinna; Atanassov, Zdravko Savov, Methods of making assay devices utilizing hollow particles.
  57. Cohen, David Samuel; Feaster, Shawn Ray, Microfluidic assay devices.
  58. Song, Xuedong; Boga, RameshBabu; Chidebelu Eze, Chibueze Obi, One-step enzymatic and amine detection technique.
  59. Cohen, David Samuel; Song, Xuedong; Knotts, Michael; Feaster, Shawn Ray; Atanassov, Zdravko Savov, Optical detection system using electromagnetic radiation to detect presence or quantity of analyte.
  60. Song, Xuedong; Wei, Ning; Sayre, Curt, Polyelectrolytic internal calibration system of a flow-through assay.
  61. Frey William A. (Wilmington DE) Simons Donald M. (Wilmington DE), Polyether polyamines as linking agents for particle reagents useful in immunoassays.
  62. Chu Victor Pichai ; Craig Alan Robert, Post synthesis chemical modification of particle reagents.
  63. Olivera, Gustavo H.; Mackie, Thomas R.; Ruchala, Kenneth J.; Reckwerdt, Paul J.; Hughes, John H.; Kapatoes, Jeffrey M.; Schnarr, Eric; Lu, Weiguo; Schloesser, Eric; Fordyce, II, Gerald D.; Holzmann, Tim, Radiation therapy imaging and delivery utilizing coordinated motion of gantry and couch.
  64. Kaylor, Rosann; Yang, Difei; Knotts, Michael, Reading device, method, and system for conducting lateral flow assays.
  65. Fitzpatrick Judith ; Lenda Regina, Receptor:release ligand (reland) complexes and release assays using said reland and methods and kits based thereon.
  66. Wei, Ning; Huang, Yanbin; Yang, Kaiyuan, Reduction of the hook effect in assay devices.
  67. Wei, Ning; Huang, Yanbin, Reduction of the hook effect in membrane-based assay devices.
  68. Wei,Ning; Huang,Yanbin, Reduction of the hook effect in membrane-based assay devices.
  69. Song,Xuedong; Kaylor,Rosann, Self-calibration system for a magnetic binding assay.
  70. Stout Richard Wayne, Stabilization of particle reagents.
  71. Ruchala, Kenneth J.; Olivera, Gustavo H.; Lu, Weiguo; Schnarr, Eric; Hughes, John H.; Kapatoes, Jeffrey M.; Mackie, Thomas R.; Reckwerdt, Paul J., System and method of delivering radiation therapy to a moving region of interest.
  72. Lu, Weiguo; Ruchala, Kenneth J.; Chen, Mingli; Chen, Quan; Olivera, Gustavo H., System and method of detecting a breathing phase of a patient receiving radiation therapy.
  73. Ruchala, Kenneth J.; Olivera, Gustavo H.; Schnarr, Eric; Lu, Weiguo; Mackie, Thomas R., System and method of evaluating dose delivered by a radiation therapy system.
  74. Kapatoes, Jeffrey M.; Olivera, Gustavo H.; Schnarr, Eric; Lu, Weiguo; Ruchala, Kenneth J.; Reckwerdt, Paul J.; Hughes, John H.; Mackie, Thomas R., System and method of generating contour structures using a dose volume histogram.
  75. Olivera, Gustavo H.; Mackie, Thomas R.; Kapatoes, Jeffrey M.; Hughes, John H.; Ruchala, Kenneth J.; Reckwerdt, Paul J., System and method of treating a patient with radiation therapy.
  76. Sutton Richard C. (Rochester NY) Littlehale Susan B. (Rochester NY) Danielson Susan J. (Rochester NY), Water-insoluble particle and immunoreactive reagent, analytical elements and methods of use.
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