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Liposomes with glycolipid-linked antibodies 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-033/54
  • G01N-033/58
출원번호 US-0374031 (1982-05-03)
발명자 / 주소
  • Szoka Frank C. (San Francisco CA)
출원인 / 주소
  • Liposome Technology Incorporated (Menlo Park CA 02)
인용정보 피인용 횟수 : 45  인용 특허 : 8

초록

Lipid vesicles, labelled with encapsulated reporter compositions and bound to antibodies comprise a new class of immunoreagent, useful in immunoassays for ligands.

대표청구항

An immunoreactive liposome reagent for use in the determination of a chemical compound capable of entering into an immunospecific reaction with a known antibody, said reagent comprising a suspension of liposomes containing reporter molecules, and a surface array of molecules of such antibody attache

이 특허에 인용된 특허 (8)

  1. Mandle Richard M. (Pompton Lakes NJ) Wong Yuan N. (Boonton NJ), Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer.
  2. Mochida Ei (Tokyo JPX) Ogawa Nobuhisa (Omiya JPX) Shinkai Hiroyuki (Kawagoe JPX) Hashimoto Masakatsu (Tokyo JPX), Immunochemical measuring process.
  3. Hsia Jen C. (Toronto CAX) Tan Chou-Tok (Toronto CAX), Immunological materials.
  4. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
  5. Ullman Edwin F. (Atherton CA) Brinkley John M. (Oakland CA), Labeled liposome particle compositions and immunoassays therewith.
  6. Sjoquist John Axel (Uppsala SW), Method of binding immunoglobulin employing a polypeptide from microorganisms.
  7. Kakimi Fujio (Minami-ashigara JPX) Hiratsuka Nobuo (Tokyo JPX) Matsukawa Hiroharu (Shizuokashi JPX), Novel material for immunological assay of biochemical components and a process for the determination of said components.
  8. Lim Franklin (Richmond VA) Moss Richard D. (Chester VA), Process of determining an immunogenic substance by competition with an antibody in a microcapsule.

이 특허를 인용한 특허 (45)

  1. Paul James Davis GB; Michael Evans Prior GB; Keith May GB, Analytical test device for imuno assays and methods of using same.
  2. Ullman Edwin F. ; Kirakossian Hrair ; Pease John S. ; Daniloff Yuri ; Wagner Daniel B., Assay method utilizing induced luminescence.
  3. Bernstein David (Sykesville MD), Assay utilizing ATP encapsulated within liposome particles.
  4. Davis,Paul James; Prior,Michael Evans; May,Keith, Assays.
  5. Davis,Paul James; Prior,Michael Evans; May,Keith, Assays.
  6. Davis,Paul James; Prior,Michael Evans; May,Keith, Assays.
  7. May,Keith; Prior,Michael Evans; Richards,Ian, Assays.
  8. May Keith,GBX ; Prior Michael Evans,GBX ; Richards Ian,GBX, Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents.
  9. May Keith,GBX ; Prior Michael Evans,GBX ; Richards Ian,GBX, Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents.
  10. May, Keith; Prior, Michael Evans; Richards, Ian, Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents.
  11. Mapes James P. (Raleigh NC) Hoke Randal A. (Cary NC), Cascade immunoassay by multiple binding reactions.
  12. Mutharasan, Rajakkannu; Rijal, Kishan; Maraldo, David R.; Campbell, Gossett Augustus, Detection of nucleic acids using a cantilever sensor.
  13. Nelson, Wilfred H.; Sperry, Jay F., Direct detection of bacteria-antibody complexes via UV resonance Raman spectroscopy.
  14. Mutharasan, Rajakkannu; Maraldo, David R.; Rijal, Kishan; Campbell, Gossett Augustus; Horan, Paul Karl, Enhanced sensitivity of a cantilever sensor via specific bindings.
  15. Watanabe Fumio (Hachioji JPX), Immunoassay method and immunoreactive cell reagent.
  16. O\Connell James P. (Chapel Hill NC) Hoke Randal A. (Carrboro NC) Mize Patrick D. (Durham NC), Immunoassay using complement.
  17. Imai Kyoko (Katsuta JPX) Nomura Yasushi (Mito JPX), Immunoassay with antigen or antibody labelled microcapsules containing fluorescent substance.
  18. Maxfield Wilson Nancy ; Larue Catherine,FRX, Immunoassays to detect antiphospholipid antibodies.
  19. Kung Viola T. (Menlo Park CA) Martin Francis J. (San Francisco CA) Vollmer Yolanda P. (Daly City CA), Large-liposome agglutination reagent and method.
  20. Jou Yi-Her (Vernon Hills IL) Hu Roger C. (Libertyville IL) Lagocki Peter A. (Park Ridge IL), Liposome based homogeneous immunoassay for diagnostic tests.
  21. Haynes Lynn C. (Morris Plaines NJ) Levine Harry (Morris Plaines NJ) Finley John W. (Whippany NJ), Liposome composition for the stabilization of oxidizable substances.
  22. Maxfield Wilson Nancy ; Larue Catherine,FRX, Liposome reagents for immunoassays.
  23. Kao Richard (Minnetonka MN) Blocki Frank A. (Chaska MN) Pranis Robert A. (Chaska MN) Mahoney Walter C. (Woodbury MN), Luminescent analyses with enhanced storage stability.
  24. Singh,Sharat; Ullman,Edwin F., Metal chelate containing compositions for use in chemiluminescent assays.
  25. Pease John S. (Los Altos CA) Kirakossian Hrair (San Jose CA) Wagner Daniel B. (Sunnyvale CA) Ullman Edwin F. (Atherton CA), Method of calibration with photoactivatable chemiluminescent matrices.
  26. Zhou, Fang X.; Schweitzer, Barry, Methods for conducting assays for enzyme activity on protein microarrays.
  27. Hoeffler, James P.; Fernandez, Joseph M.; Nasoff, Marc S., Microarray and uses therefor.
  28. Hoeffler, James P.; Fernandez, Joseph M.; Nasoff, Marc S., Microarrays and uses therefor.
  29. Hoeffler, James; Fernandez, Joseph; Nasoff, Marc, Microarrays and uses therefor.
  30. Pease John (Los Altos CA) Weng Litai (Mountain View CA) Kirakossian Hrair (San Jose CA) Ullman Edwin F. (Atherton CA), Particle with luminescer for assays.
  31. Singh, Sharat; Pease, John S.; Sadakian, Jacqueline; Wagner, Daniel B.; Ullman, Edwin F., Particles for diagnostic and therapeutic use.
  32. Singh, Sharat; Pease, John S.; Sadakian, Jacqueline; Wagner, Daniel B.; Ullman, Edwin F., Particles for diagnostic and therapeutic use.
  33. Singh,Sharat; Pease,John S.; Sadakian,Jacqueline; Wagner,Daniel B.; Ullman,Edwin F., Particles for diagnostic and therapeutic use.
  34. Pease John S. ; Kirakossian Hrair ; Wagner Daniel B. ; Ullman Edwin F., Photoactivatable chemiluminescent matrices.
  35. Roscoe, Stephen B.; Moeller, Stephanie J.; He, Yi; Ross, Richard B., Polypeptides for microbial detection.
  36. Roscoe, Stephen B.; Moeller, Stephanie J.; He, Yi; Ross, Richard B., Polypeptides for microbial detection.
  37. Piran Uri (Norwood MA), Production of loaded vesicles.
  38. Snyder, Michael; Reed, Mark; Zhu, Heng; Klemic, James Frank, Protein chips for high throughput screening of protein activity.
  39. Kilpatrick Peter K. (Raleigh NC) Carbonell Ruben G. (Raleigh NC) Powers Johnny D. (Raleigh NC), Purification by affinity binding to liposomes.
  40. Wagner Daniel B. (Raleigh NC) Baffi Robert A. (Devaulf PA), Sac having a marker linked thereto.
  41. Wagner Daniel B. (Raleigh NC) Vonk Glenn P. (Fuquay-Varina NC), Sac including a detectable metal marker and use thereof in an assay.
  42. Fleming Beverly M. (Raleigh NC) Mapes James P. (Raleigh NC), Storage and use of liposomes.
  43. Kreimer, David I.; Yevin, Oleg A.; Weber, Robert, Systems and methods for filter based spectrographic analysis.
  44. Wagner Daniel B. (Raleigh NC) Baffi Robert A. (Devaulf PA), Vesicle including a metal marker for use in an assay.
  45. Wagner Daniel B. (Raleigh NC) Piran Uri (Norwood MA), Vesicles and use thereof in an assay.
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