초록 ▼

Disclosed is a urological device comprising a polymeric prosthesis coated on its surface by a grafted or interpenetrated hydrogel copolymer comprising 2-hydroxyethyl methacrylate, methacrylic acid, and a crosslinking agent, wherein each constituent of said copolymer is present in an amount selected

Disclosed is a urological device comprising a polymeric prosthesis coated on its surface by a grafted or interpenetrated hydrogel copolymer comprising 2-hydroxyethyl methacrylate, methacrylic acid, and a crosslinking agent, wherein each constituent of said copolymer is present in an amount selected from a defined range of mole fraction %. The hydrogel exhibits a shrink/swell behavior which varies with changing urine composition such that the polymer undergoes swelling and collapse in rapid response to said change and thereby prevents calcium encrustation. Also disclosed is a method for making the device.

대표청구항 ▼

A process for making a urine-contacting physiological compatible article, comprising the steps of: A. purifying 2-hydroxyethyl methacrylate; B. adding to said purified 2-hydroxyethyl methacrylate a solvent and from between about 1 and about 3 mole fraction % of methacrylic acid and from between abou

A process for making a urine-contacting physiological compatible article, comprising the steps of: A. purifying 2-hydroxyethyl methacrylate; B. adding to said purified 2-hydroxyethyl methacrylate a solvent and from between about 1 and about 3 mole fraction % of methacrylic acid and from between about 0.01 and about 0.5 mole fraction % of a crosslinking agent to form a solution; C. forming a hydrogel coating on the urine-contacting surface of a polymeric urological prosthesis by exposing said device to said solution and causing a hydrogel copolymer comprising said 2-hydroxyethyl methacrylate, said methacrylic acid, and said crosslinking agent to form thereon. A physiologically compatible article comprising a polymeric urological prosthesis having a urine-contacting surface coating grafted or interpenetrated thereon, wherein said surface coating comprises a copolymer, said article being formed by: A. purifying 2-hydroxyethyl methacrylate; B. adding to said purified 2-hydroxyethyl methacrylate a solvent and from between about 1 and about 3 mole fraction % of methacrylic acid and a crosslinking agent to form a solution; C. forming a hydrogel coating on the surface of said polymeric urological prosthesis by exposing said prosthesis to said solution and causing a hydrogel copolymer comprising said 2-hydroxyethyl methacrylate, said methacrylic acid, and said crosslinking agent to form thereon.