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A urethral catheter composed of olefin polymer, diene polymer or silicone polymer as a base material wherein an antimicrobial substance being chemically bonded with the inside wall and/or the outside wall thereof, and a process for producing the same. This urethral catheter effectively prevents urin

A urethral catheter composed of olefin polymer, diene polymer or silicone polymer as a base material wherein an antimicrobial substance being chemically bonded with the inside wall and/or the outside wall thereof, and a process for producing the same. This urethral catheter effectively prevents urinary tract infection for a long period of time.

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1. A process for producing a urethral catheter capable of preventing urinary tract infection which comprises forming a film having functional groups capable of being converted into ion-exchange groups by hydrolysis on the inside wall and/or the outside wall of a urethral catheter composed of olefin

1. A process for producing a urethral catheter capable of preventing urinary tract infection which comprises forming a film having functional groups capable of being converted into ion-exchange groups by hydrolysis on the inside wall and/or the outside wall of a urethral catheter composed of olefin polymer, diene polymer or silicone polymer as a base material by reacting two or more compounds on said inside wall and/or said outside wall, thereafter hydrolyzing said functional groups in the film, and bonding ionically the resulting ion-exchange groups with an antimicrobial substance wherein said ion-exchange groups are carboxyl groups; said carboxyl groups are obtained by reacting (A) a copolymer of maleic acid anhydride and a copolymerizable compound with (B) a polyfunctional compound having hydroxyl groups under a condition of an excess amount of the copolymer of maleic acid anhydride and a copolymerizable compound (A) and thereafter hydrolyzing the acid anhydride groups; and the copolymer of maleic acid anhydride and a copolymerizable compound is a mixture of (I) about 0.5 to about 99.5 parts by weight of a copolymer of maleic acid anhydride and a copolymerizable vinyl monomer or olefin monomer and (II) about 0.5 to about 99.5 parts by weight of a copolymer of maleic acid anhydride and copolymerizable aliphatic vinyl ester or aliphatic vinyl ether. 2. A process according to claim 1, wherein said polyfunctional compound having hydroxyl groups is one member selected from the group consisting of polyol, polyester having hydroxyl groups on both ends, cellulose, cellulose derivatives, polyvinyl alcohol and polyvinyl alcohol derivatives. 3. A process according to claim 2, wherein said polyol is polyethylene glycol. 4. A process according to claim 1, wherein said aromatic vinyl monomer is styrene. 5. A process according to claim 1, wherein said olefin monomer is ethylene or propylene. 6. A process according to claim 1, wherein said aliphatic vinyl ether is one member selected from the group consisting of methyl vinyl ether, ethyl vinyl ether and butane-diol vinyl ether. 7. A process according to claim 1, wherein said aliphatic vinyl ester is vinyl acetate.