[미국특허]
Film-forming composition containing an antimicrobial agent and methods
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/70
A61K-031/79
A61L-015/00
출원번호
US-0465806
(1983-02-11)
발명자
/ 주소
Dell, John D.
출원인 / 주소
Minnesota Mining and Manufacturing Company
대리인 / 주소
Sell, Donald M.Smith, James A.Sprague, Robert W.
인용정보
피인용 횟수 :
92인용 특허 :
2
초록▼
A dermatologically acceptable, film-forming composition which comprises a film-forming polymer and, as a broad spectrum antimicrobial agent, iodine which forms a complex with the film-forming polymer. The compositions when applied to skin from a fugitive solvent form a substantially water-insoluble,
A dermatologically acceptable, film-forming composition which comprises a film-forming polymer and, as a broad spectrum antimicrobial agent, iodine which forms a complex with the film-forming polymer. The compositions when applied to skin from a fugitive solvent form a substantially water-insoluble, tack-free, flexible film which adheres to skin, releases the antimicrobial agent when the film is in contact with skin, and exhibits an elongation of at least about 150%. A method of using the composition is also described.
대표청구항▼
1. A dermatologically acceptable, film-forming composition, comprising: (a) a film-forming polymer which is the reaction product of (i) a prepolymer having a plurality of isocyanate functionalities, said prepolymer being the reaction product of a polyisocyanate, a major amount of which by weight
1. A dermatologically acceptable, film-forming composition, comprising: (a) a film-forming polymer which is the reaction product of (i) a prepolymer having a plurality of isocyanate functionalities, said prepolymer being the reaction product of a polyisocyanate, a major amount of which by weight is diisocyanate, and an isocyanate-reactive compound having a plurality of functionalities selected from the group consisting of a hydroxy group, a primary amine group, a secondary amine group, a thiol group, and a combination of at least two of the foregoing, a major amount of said isocyanate-reactive compound being difunctional with respect to said functionalities contained therein; (ii) a polyvinylpyrrolidone polymer which is the free-radical polymerization reaction product of at least n-vinylpyrrolidone and a vinyl-functional compound; and (iii) a chain-extender for said prepolymer and said polyvinylpyrrolidone polymer, said chain-extender having a plurality of functionalities selected from the group consisting of a hydroxy group, a primary amine group, a secondary amine group, a thiol group, and a combination of at least two of the foregoing, a major amount of said chain-extender being difunctional with respect to said functionalities contained therein; said vinyl-functional compound being further characterized in that it contains a functionality having reactivity with said chain-extender which is substantially equivalent to reactivity of the isocyanate functionalities of said prepolymer with said chain-extender; and (b) as an antimicrobial agent, iodine which forms a complex with said film-forming polymer; said composition when applied to skin from a fugitive solvent being capable of forming a substantially water-insoluble, substantially tack-free, flexible film which adheres to skin, releases iodine, when said film is in contact with the skin, and exhibits an elongation of between about 150% and 1000%. 2. A composition in accordance with claim 1, wherein said prepolymer is the reaction product of a diisocyanate with an isocyanate-reactive compound selected from the group consisting of a diol having a molecular weight of between about 750 and 2500 and a diamine having two primary amine groups and having a molecular weight of between about 750 and 2500. 3. A composition in accordance with claim 2, wherein said isocyanate-reactive compound is a diol which is selected from the group consisting of a polyether diol and a polyester diol and wherein said diisocyanate is an aliphatic diisocyanate. 4. A composition in accordance with claim 1, wherein said polyvinylpyrrolidone polymer is the free-radical-polymerization reaction product of n-vinylpyrrolidone and an isocyanate-functional acrylate or methacrylate. 5. A composition in accordance with claim 4, wherein said polyvinylpyrrolidone polymer is prepared from said n-vinylpyrrolidone and said isocyanate-functional acrylate or methacrylate in a weight ratio of from about 99:1 to 90:10. 6. A composition in accordance with claim 1, wherein said polyvinylpyrrolidone polymer is the free-radical-polymerization reaction product of n-vinylpyrrolidone and a vinyl-functional azlactone. 7. A composition in accordance with claim 6, wherein said polyvinylpyrrolidone polymer is prepared from said n-vinylpyrrolidone and said vinyl-functional azlactone in a weight ratio of from about 99:1 to 90:10. 8. A composition in accordance with claim 1, wherein said chain-extender is selected from the group consisting of a diamine having two primary amine groups and a diol. 9. A composition in accordance with claim 8, wherein said chain-extender is selected from the group consisting of an aliphatic diamine having two primary amine groups and a diol. 10. A composition in accordance with claim 1, wherein the weight ratio of the amount of the polyvinylpyrrolidone polymer employed to the amount of the prepolymer employed in preparing said film-forming polymer is from about 2:98 to 20:80 and said chain-extender is employed in the amount of about 0.4 to 1 equivalents per equivalent of the sum total of reactive functionality of said prepolymer and said polyvinylpyrrolidone polymer. 11. A composition in accordance with claim 10, wherein the weight ratio of the amount of the polyvinylpyrrolidone polymer employed to the amount of the prepolymer employed in preparing said film-forming polymer is from about 5:95 to 15:85. 12. A composition in accordance with claim 11, wherein the weight ratio of the amount of the polyvinylpyrrolidone polymer employed to the amount of the prepolymer employed in preparing said film-forming polymer is from about 7:93 to 12:88. 13. A composition in accordance with claim 1, further comprising an alcohol selected from the group consisting of ethanol and isopropanol, said film-forming polymer being dissolved in said alcohol. 14. A composition in accordance with claim 1, wherein said composition when applied to skin from a fugitive solvent is capable of forming a film which exhibits a tensile strength of at least about 1500 psi and an elongation of between about 150% and 1000%. 15. A composition in accordance with claim 1, wherein said composition when applied to skin from a fugitive solvent is capable of forming a film which exhibits a tensile strength of at least about 2000 psi and an elongation of between about 200% and 1000%. 16. A composition in accordance with claim 1, wherein said composition when applied to skin from a fugitive solvent is capable of forming a film which exhibits a tensile strength of at least about 2500 psi and an elongation of between about 250% and 1000%. 17. A method of promoting asepsis on mammalian skin, comprising the steps of: (a) applying to said skin said composition of claim 1; and (b) allowing said composition to dry to form said film. 18. The method in accordance with claim 17, wherein said film is peeled substantially intact from said skin once the need for asepsis has discontinued. 19. The method in accordance with claim 17, wherein said film is removed from said skin using a remover solution once the need for asepsis has discontinued. 20. The method in accordance with claim 17, wherein said film is allowed to wear off once the need for asepsis has discontinued.
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