Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites
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IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-043/00
A61K-049/00
A61K-049/02
C07C-103/52
출원번호
US-0498736
(1983-05-27)
발명자
/ 주소
Gavras Haralambos P. (11 Coolidge Rd. Wayland MA 01778) Ryan James W. (3420 Poinciana Ave. Miami FL 33133) Chung Alfred (8781 SW. 87th Ave. Miami FL 33125)
인용정보
피인용 횟수 :
64인용 특허 :
29
초록▼
Radiolabeled angiotensin converting enzyme inhibitors having the general formula: [Figure] wherein X is a radiolabeling substituent, preferably a radiolabeling halogen substituent such as 123I, 125I, 131I, 75Br or 77Br, Y is hydroxy, alkoxy containing from 1 to 6 carbon atoms, phenoxy, benzyloxy, or
Radiolabeled angiotensin converting enzyme inhibitors having the general formula: [Figure] wherein X is a radiolabeling substituent, preferably a radiolabeling halogen substituent such as 123I, 125I, 131I, 75Br or 77Br, Y is hydroxy, alkoxy containing from 1 to 6 carbon atoms, phenoxy, benzyloxy, or amino, R1 is hydrogen or methyl, R2 is hydrogen, an ester moiety hydrolyzable under mammalian in vivo conditions, such as alkyl of 1 or 2 carbon atoms, phenyl or benzyl, or an ionically bonded anion of a physiologically acceptable non-toxic salt, and m is an integer of from 1 to 6, are useful as in vivo radioimaging compounds for mammalian sites.
대표청구항▼
A radiolabeled angiotensin converting enzyme (ACE) inhibitor having the general formula: [Figure] wherein X is a radiolabeling substituent, Y is hydroxy, alkoxy containing from 1 to 6 carbon atoms, phenoxy, benzyloxy or amino, R1 is hydrogen or methyl, R2 is hydrogen, an ester moiety hydrolyzable un
A radiolabeled angiotensin converting enzyme (ACE) inhibitor having the general formula: [Figure] wherein X is a radiolabeling substituent, Y is hydroxy, alkoxy containing from 1 to 6 carbon atoms, phenoxy, benzyloxy or amino, R1 is hydrogen or methyl, R2 is hydrogen, an ester moiety hydrolyzable under mammalian in vivo conditions or an ionically bonded anion of a physiologically acceptable non-toxic salt, and m is an integer of from 1 to 6. A method of radioimaging a mammalian site which comprises administering into a blood vessel in the mammal a dose of from about 0.01 mg to about 15 mg, per kilogram of body weight, of a radiolabeled angiotensin converting enzyme (ACE) inhibitor as described in claim 1, and then scanning the mammal to produce an image of the site.
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