IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0592446
(1984-03-22)
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우선권정보 |
JP-0040032 (1979-04-02); JP-0103340 (1979-08-13) |
발명자
/ 주소 |
- Ono Keiichi (1-5-3-530 Higashiawaji
- Higashiyodogawa-ku
- Osaka JPX) Kawakami Hajime (2-14-7 Mefu
- Takarazuka
- Hyogo JPX) Katsube Junki (10-20 Machikaneyama-cho Toyonaka
- Osaka JPX)
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인용정보 |
피인용 횟수 :
2 인용 특허 :
1 |
초록
▼
Diphenylalkanoether and diphenylalkanone oximeether derivatives of the formula: [Figure] wherein R1 and R2 are each independently an aryl group optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, nitro, cyano, di(C1-C4)alkylamino,
Diphenylalkanoether and diphenylalkanone oximeether derivatives of the formula: [Figure] wherein R1 and R2 are each independently an aryl group optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, nitro, cyano, di(C1-C4)alkylamino, amino, benzyloxy, hydroxyl, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 alkanoylamino, C1-C4 alkylamino and N-(C1-C4 )alkyl-N-(C1-C4)alkanoylamino, Z1 is a group of the formula: [Figure] (wherein R3 and R4 are each independently a hydrogen atom, a C1-C4 alkyl group or an ar(C1-C4)alkyl group or, when taken together with the adjacent nitrogen atom to which they are attached, represent a nitrogen-containing 5 to 7-membered saturated heterocyclic group optionally having an oxygen atom or an additional nitrogen atom as the hetero atom in addition to the said nitrogen atom and, in case of having the additional nitrogen atom, bearing a hydrogen atom, a C1- C4 alkyl group, an ar(C1-C4)alkyl group or a phenyl group thereon), [Figure] is a group of the formula: [Figure] or the formula: [Figure] A1 is a C2-C6 alkylene group and A2 is a C2-C4 alkylene group, and non-toxic, pharmaceutically acceptable acid addition salts thereof, which have cerebral vasodilating activity and antihypoxic activity.
대표청구항
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A compound of the formula: [Figure] wherein R1 and R2 are each independently an aryl group optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, nitro, cyano, di(C1-C4)alkylamino, amino, benzyloxy, hydroxyl, C1-C4 alkylthio, C1-C4 a
A compound of the formula: [Figure] wherein R1 and R2 are each independently an aryl group optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, nitro, cyano, di(C1-C4)alkylamino, amino, benzyloxy, hydroxyl, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 alkanoylamino, C1-C4 alkylamino and N-(C1-C4)alkyl-N-(C1-C4)alkanoylamino; Z1 is a group of the formula: [Figure] wherein R3 and R4 are each independently a hydrogen atom, a C1-C4 alkyl group or an ar(C1-C4)alkyl group or, when taken together with the adjacent nitrogen atom to which they are attached, represent a nitrogen-containing 5 to 7-membered saturated heterocyclic group optionally having an oxygen atom or an additional nitrogen atom as the hetero atom in addition to the said nitrogen atom and, in case of having the additional nitrogen atom, bearing a hydrogen atom, a C1-C4 alkyl group, an ar(C1-C4)alkyl group or a phenyl group thereon; A1 is a C3-C6 alkylene group; and A2 is a C2-C4 alkylene group, and non-toxic, pharmaceutically acceptable acid addition salts thereof.
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