초록 ▼

A process for the production of an unnative and biologically active bonded collagen fiber sheet from human placentae is described, in which process collagen-containing material from placentae is treated with a neutral salt solution, a solution of citric acid and with pepsin. The degraded collagen ma

A process for the production of an unnative and biologically active bonded collagen fiber sheet from human placentae is described, in which process collagen-containing material from placentae is treated with a neutral salt solution, a solution of citric acid and with pepsin. The degraded collagen material obtained in this manner is, where appropriate, treated with a crosslinking agent. The collagen material produced in this manner is used for producing bonded collagen fiber sheets which can be used, for example, as covering for wounds.

대표청구항 ▼

A process for the production of a bonded collagen fiber sheet by sequentially treating collagen containing material, which have been comminuted and washed free of blood, with a 0.5-4 molar neutral salt solution, a 0.5-2 molar citric acid solution at pH 1-4, a pepsin solution, and, where appropriate,

A process for the production of a bonded collagen fiber sheet by sequentially treating collagen containing material, which have been comminuted and washed free of blood, with a 0.5-4 molar neutral salt solution, a 0.5-2 molar citric acid solution at pH 1-4, a pepsin solution, and, where appropriate, with an ion exchanger resin to remove low and high molecular weight contaminants, precipitating the collagen with sodium chloride, dissolving the preciptate in a weakly buffered solution at pH 4-6 to form a collagen solution, dialyzing the collagen solution against water so as to precipitate the collagen fibrils, suspending the collagen fibrils and drying the collagen. The application of a bonded fiber sheet produced in accordance with the process of claims 3 or 2 as a covering for wounds.