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특허 상세정보

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Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentrati

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-009/26    A61K-031/74   
미국특허분류(USC) 424/22 ; 424/19 ; 424/81
출원번호 US-0608756 (1984-05-10)
발명자 / 주소
출원인 / 주소
인용정보 피인용 횟수 : 55  인용 특허 : 13
초록
▼

An active agent containing controlled release diffusion device comprising a swellable hydrogel matrix in the non-swollen state, interpenetrated with an active agent solute having a stable concentration distribution increasing in a gradient normal to the surface of the device and between the surface and the core thereof, said gradient being in the form of a substantially continuous, inflection point containing, sigmoidal curve, such that the device, when placed in an aqueous hydrogel swelling environment, releases said active agent in a controlled continu...

대표
청구항
▼

An active agent containing controlled release diffusion device comprising a swellable hydrogel matrix in the non-swollen state, interpenetrated with an active agent solute having a stable concentration distribution increasing in a gradient normal to the surface of th device and between the surface and the core thereof, said gradient being in the form of a substantially continuous, inflection point containing, sigmoidal curve, wherein the core is substantially uniformly loaded with active agent and extends outwardly from the center of the device to about ...

이 특허에 인용된 특허 (13)

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  8. Cohen Arthur I. (Rochester NY) Sim James S. Y. (Rochester NY) Van Horn Maurice H. (Rochester NY) Gordesky Stanley E. (Rochester NY) Gordon Stanley I. (Rochester NY). Sustained release pharmaceutical composition. USP1979124178361.
  9. Blank Izhak (Haifa IL). Sustained release polymers. USP1976053959237.
  10. Folkman Moses J. (18 Chathman Cir. Brookline MA 02146) Langer ; Jr. Robert S. (1200 Commonwealth ; Apt. 2 Allston MA 02134). Systems for the controlled release of macromolecules. USP1979084164560.
  11. Mueller Karl F. (New York NY) Good William R. (Yorktown Height NY). Water-insoluble hydrophilic copolymers used as carriers for medicaments and pesticides. USP1981124304591.
  12. Mueller Karl F. (New York NY) Good William R. (Yorktown Heights NY). Water-insoluble hydrophilic copolymers used as carriers for medicaments and pesticides. USP1979124177056.
  13. Kraemer ; Dieter ; Lehmann ; Klaus ; Pennewiss ; Horst ; Plainer ; Herma nn ; Schweder ; Roland. Water-swellable, bead copolymer. USP1978014070348.

이 특허를 인용한 특허 피인용횟수: 55

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  2. Tseng, Scheffer; He, Hua; Li, Wei. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment. USP2017099750772.
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  4. Tseng, Scheffer; He, Hua; Li, Wei. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment. USP2012058187639.
  5. Tseng, Scheffer; He, Hua; Li, Wei. Amniotic membrane preparations and purified compositions and anti-inflammation methods. USP2015109161956.
  6. Tseng, Scheffer; He, Hua; Li, Wei. Amniotic membrane preparations and purified compositions and anti-inflammation methods. USP2017099750771.
  7. Tseng, Scheffer; He, Hua; Li, Wei. Amniotic membrane preparations and purified compositions and anti-inflammation methods. USP2012058182841.
  8. Tseng, Scheffer; He, Hua; Li, Wei. Amniotic membrane preparations and purified compositions and anti-inflammation methods. USP2013068455009.
  9. Tseng, Scheffer; He, Hua; Li, Wei. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition. USP2015109161955.
  10. Tseng, Scheffer; He, Hua; Li, Wei. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition. USP2017089724370.
  11. Tseng, Scheffer; He, Hua; Li, Wei. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition. USP2012058182840.
  12. Tseng, Scheffer; He, Hua; Li, Wei. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition. USP2013058440235.
  13. Tseng, Scheffer; He, Hua. Compositions containing HC-HA complex and methods of use thereof. USP2015119175066.
  14. Tseng, Scheffer; He, Hua; Tighe, Sean; Zhang, Suzhen; Zhu, Ying-Tieng. Compositions containing HC-HA/PTX3 complexes and methods of use thereof. USP20190410253065.
  15. Tseng, Scheffer; He, Hua; Tighe, Sean; Zhang, Suzhen; Zhu, Ying-Tieng. Compositions containing HC-HA/PTX3 complexes and methods of use thereof. USP20180810040821.
  16. Tseng, Scheffer; Chua, Lorraine. Compositions of morselized umbilical cord and/or amniotic membrane and methods of use thereof. USP2017119808491.
  17. Hanna, Mazen H.; York, Peter. Compositions of particulate coformulation. USP2015099120031.
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  20. Simon, Julian; Johnson, Graham; Rubel, Edwin; Chowdhury, Sarwat; Herr, R. Jason; Jiang, Qin; Chen, Xinchao; Owens, Kelly N; Raible, David. Compounds and methods for preventing, treating and/or protecting against sensory hair cell death. USP2016089416141.
  21. Cao, Jianguo; Wang, Zhijun; Grey, Jonathan; Rogers, Evan; Whitten, Jeffrey P.. Compounds that modulate intracellular calcium. USP2017049611263.
  22. Rogers, Evan; Cao, Jianguo; Wang, Zhijun; Grey, Jonathan; Whitten, Jeffrey P.. Compounds that modulate intracellular calcium. USP2016129512116.
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  34. Tseng, Scheffer; Tan, Ek Kia; He, Hua. Methods of modulating bone remodeling. USP2016129526770.
  35. Tseng, Scheffer; Tan, Ek Kia; He, Hua. Methods of modulating bone remodeling. USP2017069675733.
  36. Tseng, Scheffer; Tan, Ek Kia; Chua, Lorraine. Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof. USP2017069682044.
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  48. Chen, Wei; Loury, David J.. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors. USP2016039273051.
  49. Tuttle, Susan Bane; Dilek, Ozlem; Mukherjee, Kamalika. Rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjunction therewith. USP2017099758533.
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  52. Banister, Mark; McGrath, Dominic. Super elastic epoxy hydrogel. USP20190210208158.
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