초록 ▼

An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers. The material is prepared by passing reconstituted collagen fibers repeatedly through a rigid mesh screen, until a substantial reduction in fiber size and size-heterogeneity is achieved. The

An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers. The material is prepared by passing reconstituted collagen fibers repeatedly through a rigid mesh screen, until a substantial reduction in fiber size and size-heterogeneity is achieved. The mechanically sheared fibers may be further crosslinked to improve implant characteristics.

대표청구항 ▼

An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers and characterized, with respect to unsheared, but otherwise identical, collagen material measured under the same conditions, by: about a 30%-70% decrease in the force required to inject the m

An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers and characterized, with respect to unsheared, but otherwise identical, collagen material measured under the same conditions, by: about a 30%-70% decrease in the force required to inject the material, at a concentration of between about 35-65 mg/ml, through a 27-30 gauge needle, and b. a substantial decrease in the number and magnitude of transient increases in force required for injecting the material, at such concentration, through such needle.