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[미국특허] Fluorescent energy transfer with phycobiliproteins 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-033/566
  • G01N-033/536
  • G01N-033/542
출원번호 US-0640499 (1984-08-14)
발명자 / 주소
  • Chan Joseph L. W. (Quincy MA)
출원인 / 주소
  • Ortho Diagnostic Systems Inc. (Raritan NJ 02)
인용정보 피인용 횟수 : 39  인용 특허 : 6

초록

Dyes are provided comprising phycobiliproteins having covalently coupled thereto a plurality of small molecular weight organic dyes under conditions permitting energy transfer mechanisms to operate therebetween. The resultant label may then be used in virtually any immunoassay format.

대표청구항

In a method for the detection of a ligand by detecting an immunological reaction between said ligand and a ligand binding receptor specific therefor, the improvement comprising detecting said immunological reaction by detecting a label associated with one of said ligand or ligand binding receptor co

이 특허에 인용된 특허 (6) 인용/피인용 타임라인 분석

  1. Hirschfeld Tomas (Framingham MA), Dye tagged reagent.
  2. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
  3. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
  4. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
  5. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Sunnyvale CA), Fluorescence quenching with immunological pairs in immunoassays.
  6. Stryer, Lubert; Glazer, Alexander N., Phycobiliprotein fluorescent conjugates.

이 특허를 인용한 특허 (39) 인용/피인용 타임라인 분석

  1. Sharat Singh ; Edwin F. Ullman, Chemiluminescent compositions for use in detection of multiple analytes.
  2. Palmer Derek Adeyemi,GBX ; French Martin Thomas,GBX, Composition for use in fluorescence assay systems.
  3. Coull, James M.; Gildea, Brian D.; Hyldig-Nielsen, Jens J., Compositions comprising a linked acceptor moiety.
  4. Gildea,Brian D.; Coull,James M.; Hyldig Nielsen,Jens J.; Fiandaca,Mark J., Detection of nucleic acid using linear beacons.
  5. Buechler Kenneth F. ; Noar J. Barry ; Tadesse Lema, Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds.
  6. Buechler Kenneth F. ; Noar Joseph Barry ; Tadesse Lema, Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds.
  7. Lippa Arnold S. (Franklin Lakes NJ), Fluorescence immunoassay involving energy transfer between two fluorophores.
  8. Heller Michael J. (Poway CA) Jablonski Edward J. (San Diego CA), Fluorescent stokes shift probes for polynucleotide hybridization.
  9. Buechler Kenneth F. ; Noar Joseph B. ; Tadesse Lema, Hybrid phthalocyanine derivatives and their uses.
  10. Buechler,Kenneth F.; Noar,Joseph B.; Tadesse,Lema, Hybrid phthalocyanine derivatives and their uses.
  11. Buechler,Kenneth F.; Noar,Joseph B.; Tadesse,Lema, Hybrid phthalocyanine derivatives and their uses.
  12. Gildea, Brian D.; Coull, James M.; Hyldig-Nielsen, Jens J., In-situ methods for analyzing target sequences using linear beacons.
  13. Wang, Ruizheng; Harder, John W.; Stegman, David A.; Harrison, William J.; Schmitthenner, Hans F., Large stoke shift dye used for optical imaging.
  14. Cubicciotti, Roger, Light harvesting optical, optoelectronic, and photovoltaic devices.
  15. Ji, Tao; Schmitthenner, Hans F.; Yang, Yonghong; Harder, John W.; Leon, Jeffrey W.; Harrison, William J.; Kelley, Brian J.; Bennett, James R.; Stegman, David A.; Wang, Ruizheng, Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes.
  16. Bukshpan,Shmuel; Zilberstein,Gleb, Method for sorting and separating living cells.
  17. Gupta Ravinder K. (Pembroke Pines FL), Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and.
  18. Gupta Ravinder K., Method of preferential labelling of a phycobiliprotein with an aminereactive dye for use in a multiple color assay and.
  19. James M. Coull ; Brian D. Gildea ; Jens J. Hyldig-Nielsen, Method, kits and compositions pertaining to detection complexes.
  20. Coull, James M.; Gildea, Brian D.; Hyldig-Nielsen, Jens J., Methods, kits and compositions pertaining to PNA Molecular Beacons.
  21. Coull, James M.; Gildea, Brian D.; Hyldig-Nielsen, Jens J., Methods, kits and compositions pertaining to PNA molecular beacons.
  22. James M. Coull ; Brian D. Gildea ; Jens J. Hyldig-Nielsen, Methods, kits and compositions pertaining to PNA molecular beacons.
  23. Coull, James M.; Gildea, Brian D.; Hyldig-Nielsen, Jens J., Methods, kits and compositions pertaining to detection complexes.
  24. Brian D. Gildea ; James M. Coull ; Jens J. Hyldig-Nielsen ; Mark J. Fiandaca, Methods, kits and compositions pertaining to linear beacons.
  25. Gildea, Brian D.; Coull, James M.; Hyldig-Nielsen, Jens J.; Fiandaca, Mark J., Methods, kits and compositions pertaining to linear beacons.
  26. Roger S. Cubicciotti, Modified phycobilisomes and uses therefore.
  27. Waterbury John B. (Woods Hole MA) Watson Stanley W. (Woods Hole MA) Glazer Alexander N. (Orinda CA) Ong Linda J. (Hayward CA), Phycoerythrins useful in fluorescent conjugates.
  28. Ramage Robert,GB6 ; Raphy Gilles,GB6, Protected compound comprising a protective group removably attached to a compound to be protected.
  29. Robert Ramage GB; Gilles Raphy GB, Protective group, compound protected by said group and device for grafting the protective group on the compound to protect it.
  30. Kobayashi Takeshi,JPX ; Honda Hiroyuki,JPX ; Shimada Ken-ichi,JPX, Reagent for biomaterials assay, preparation method thereof, and assay method.
  31. Cubicciotti,Roger S., Signal processing devices comprising biological and bio-mimetic components.
  32. Kardos Keith W. ; Niedbala R. Sam ; Burton Jarrett Lee ; Cooper David E. ; Zarling David A. ; Rossi Michel J.,CHX ; Peppers Norman A. ; Kane James ; Faris Gregory W. ; Dyer Mark J. ; Ng Steve Y. ; Sc, Up-converting reporters for biological and other assays.
  33. Kardos Keith W. ; Niedbala R. Sam ; Burton Jarrett Lee ; Cooper David E. ; Zarling David A. ; Rossi Michel J.,CHX ; Peppers Norman A. ; Kane James ; Faris Gregory W. ; Dyer Mark J. ; Ng Steve Y. ; Sc, Up-converting reporters for biological and other assays.
  34. David A. Zarling ; Michel J. Rossi CH; Norman A. Peppers ; James Kane ; Gregory W. Faris ; Mark J. Dyer ; Steve Y. Ng ; Luke V. Schneider, Up-converting reporters for biological and other assays using laser excitation techniques.
  35. Zarling David A. (Menlo Park CA) Rossi Michel J. (Lausanne CHX) Peppers Norman A. (Belmont CA) Kane James (Lawrenceville NJ) Faris Gregory W. (Menlo Park CA) Dyer Mark J. (San Jose CA) Ng Steve Y. (S, Up-converting reporters for biological and other assays using laser excitation techniques.
  36. Zarling David A. (Menlo Park CA) Rossi Michel J. (Lausanne CHX) Peppers Norman A. (Belmont CA) Kane James (Lawrenceville NJ) Faris Gregory W. (Menlo Park CA) Dyer Mark J. (San Jose CA) Ng Steve Y. (S, Up-converting reporters for biological and other assays using laser excitation techniques.
  37. Zarling David A. ; Rossi Michel J.,CHX ; Peppers Norman A. ; Kane James ; Faris Gregory W. ; Dyer Mark J. ; Ng Steve Y. ; Schneider Luke V., Up-converting reporters for biological and other assays using laser excitation techniques.
  38. Zarling David A. ; Rossi Michel J.,CHX ; Peppers Norman A. ; Kane James ; Faris Gregory W. ; Dyer Mark J. ; Ng Steve Y. ; Schneider Luke V., Up-converting reporters for biological and other assays using laser excitation techniques.
  39. Zarling, David A.; Rossi, Michel J.; Peppers, Norman A.; Kane, James; Faris, Gregory W.; Dyer, Mark J.; Ng, Steve Y.; Schneider, Luke V., Up-converting reporters for biological and other assays using laser excitation techniques.

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