이 특허를 인용한 특허 (262)

1. Manoharan Muthiah ; Kawasaki Andrew M. ; Cook Phillip Dan ; Fraser Allister S. ; Prakash Thazha P., 2'-O-acetamido modified monomers and oligomers.

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2. Cook Phillip Dan ; Guinosso Charles John, 2'-O-modified nucleosides and phosphoramidites.

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3. Prakash, Thazha P.; Baker, Brenda F.; Eldrup, Anne B.; Manoharan, Muthiah; Bhat, Balkrishen; Griffey, Richard; Swayze, Eric E.; Crooke, Stanley T., 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations.

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4. Seth, Punit P.; Swayze, Eric E.; Bhat, Balkrishen, 5'-modified bicyclic nucleic acid analogs.

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5. Swayze, Eric E.; Prakash, Thazha P., 5′ and 2′ BIS-substituted nucleosides and oligomeric compounds prepared therefrom.

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6. Prakash, Thazha P.; Seth, Punit P.; Swayze, Eric E., 5′ modified nucleosides and oligomeric compounds prepared therefrom.

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7. Seth, Punit P.; Swayze, Eric E.; Bhat, Balkrishen, 5′-modified bicyclic nucleic acid analogs.

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8. Seth, Punit P.; Swayze, Eric E.; Bhat, Balkrishen, 5′-modified bicyclic nucleic acid analogs.

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9. Seth, Punit P.; Swayze, Eric E.; Bhat, Balkrishen, 5′-modified bicyclic nucleic acid analogs.

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10. Seth, Punit P.; Swayze, Eric E., 6-disubstituted or unsaturated bicyclic nucleic acid analogs.

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11. Seth, Punit P.; Swayze, Eric E., 6-modified bicyclic nucleic acid analogs.

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12. Seth, Punit P.; Swayze, Eric E., 6-modified bicyclic nucleic acid analogs.

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13. Seth,Punit P.; Swayze,Eric E., 6-modified bicyclic nucleic acid analogs.

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14. Manoharan, Muthia; Ravikumar, Vasulinga T., Activators for oligonucleotide synthesis.

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15. Manoharan, Muthia; Ravikumar, Vasulinga T., Activators for oligonucleotide synthesis.

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16. Sanghvi Yogesh ; Manoharan Muthiah, Activators for oligonucleotide synthesis.

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17. Peck, Konan; Cheng, Ji-Yen, Apparatus and methods for chemical synthesis.

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18. Hoerr, Ingmar; Von Der Mülbe, Florian; Pascolo, Steve, Application of mRNA for use as a therapeutic against tumor diseases.

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19. Hoerr, Ingmar; Von Der Mulbe, Florian; Pascolo, Steve, Application of mRNA for use as a therapeutic against tumour diseases.

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20. Hoerr, Ingmar; Von Der Mülbe, Florian; Pascolo, Steve, Application of mRNA for use as a therapeutic against tumour diseases.

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21. Hoerr, Ingmar; Von Der Mülbe, Florian; Pascolo, Steve, Application of mRNA for use as a therapeutic against tumour diseases.

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22. Hoerr, Ingmar; Von Der Mülbe, Florian; Pascolo, Steve, Application of mRNA for use as a therapeutic against tumour diseases.

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23. Hoerr, Ingmar; Von Der Mülbe, Florian; Pascolo, Steve, Application of mRNA for use as a therapeutic against tumour diseases.

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24. Hoerr, Ingmar; Von Der Mulbe, Florian; Pascolo, Steve, Application of mRNA for use as a therapeutic agent for tumorous diseases.

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25. Myers,Andrew G.; LaPorte,Jacob R.; Xing,Chengguo, Assay for identifying biological targets of polynucleotide-binding compounds.

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26. Shimizu, Mamoru; Wada, Takeshi, Asymmetric auxiliary group.

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27. Smith Lloyd M. ; Hood Leroy E. ; Hunkapiller Michael W. ; Hunkapiller Tim J. ; Connell Charles R., Automated DNA sequencing technique.

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28. Smith Lloyd M. ; Hood Leroy E. ; Hunkapiller Michael W. ; Hunkapiller Tim J. ; Connell Charles R., Automated DNA sequencing technique.

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29. Allerson, Charles; Bhat, Balkrishen; Swayze, Eric E., Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom.

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30. Seth, Punit P.; Swayze, Eric E., Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom.

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31. Seth, Punit P.; Migawa, Michael T.; Swayze, Eric E.; Song, Quanlai; Han, Mingming; Ross, Bruce S., Bicyclic cyclohexitol nucleic acid analogs.

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32. Migawa, Michael T.; Seth, Punit P.; Swayze, Eric E.; Ross, Bruce S.; Song, Quanlai; Han, Mingming, Bicyclic cyclohexose nucleic acid analogs.

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33. Seth, Punit P.; Swayze, Eric E., Bicyclic morpholino compounds and oligomeric compounds prepared therefrom.

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34. Seth, Punit P.; Swayze, Eric E.; Hanessian, Stephen; Schroeder, Benjamin R., Bicyclic nucleosides and oligomeric compounds prepared therefrom.

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35. Seth, Punit P.; Swayze, Eric E., Bis-modified bicyclic nucleic acid analogs.

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36. Seth, Punit P.; Swayze, Eric E., Bis-modified bicyclic nucleic acid analogs.

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37. Phillip Dan Cook ; Haoyun An ; Tingmin Wang ; Muthiah Manoharan, C3'-methylene hydrogen phosphonate monomers and related compounds.

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38. Cook, Phillip Dan; Manoharan, Muthiah; Maier, Martin; An, Haoyun, C3'-methylene hydrogen phosphonate oligomers and related compounds.

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39. Cook, Phillip Dan; Manoharan, Muthiah; Maier, Martin; An, Haoyun, C3′ -methylene hydrogen phosphonate oligomers and related compounds.

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40. Seth, Punit P.; Swayze, Eric E., Carbocyclic bicyclic nucleic acid analogs.

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41. Ecker, David J.; Acevedo, Oscar; Hebert, Normand; Davis, Peter W.; Wyatt, Jacqueline R.; Kiely, John S., Chemical reaction apparatus and methods.

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42. Ecker David J. ; Acevedo Oscar ; Hebert Normand ; Davis Peter W. ; Wyatt Jacqueline R. ; Kiely John S., Chemical reaction apparatus for performing multiple reaction on a surface and collecting the product.

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43. Ecker David J. ; Acevedo Oscar ; Hebert Normand ; Davis Peter W. ; Wyatt Jacqueline R. ; Kiely John S., Chemical synthesis apparatus employing a droplet generator.

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44. Crooke, Stanley T., Chimeric oligomeric compounds and their use in gene modulation.

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45. Butler, David; Iwamoto, Naoki; Meena; Svrzikapa, Nenad; Verdine, Gregory L.; Zlatev, Ivan, Chiral control.

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46. Butler, David; Iwamoto, Naoki; Meena; Svrzikapa, Nenad; Verdine, Gregory L.; Zlatev, Ivan, Chiral control.

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47. Meena; Butler, David; Iwamoto, Naoki; Svrzikapa, Nenad; Verdine, Gregory L.; Zlatev, Ivan, Chiral design.

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48. Gemba, Takefumi, Chiral nucleic acid adjuvant.

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49. Gemba, Takefumi; Nagata, Ryoichi; Torikai, Yusuke, Chiral nucleic acid adjuvant having antitumor effect and antitumor agent.

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50. Gemba, Takefumi; Nagata, Ryoichi; Shiga, Ikumi, Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator.

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51. Krotz, Achim; Capaldi, Daniel C.; Gaus, Hans-Joachim Josef; Turney, Brett, Chloral-free DCA in oligonucleotide synthesis.

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52. Krotz,Achim; Capaldi,Daniel; Gaus,Hans; Turney,Brett, Chloral-free DCA in oligonucleotide synthesis.

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53. Dellinger,Douglas J; Dellinger,Geraldine F; Caruthers,Marvin H, Cleavable linker for polynucleotide synthesis.

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54. Bennett, Clarence Frank; Ecker, David J.; Cook, Phillip Dan, Composition and methods for the pulmonary delivery of nucleic acids.

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55. Chiarello,Ronald H.; Liu,Wing Cheong; Alvarado,Gabriel G., Compositions and methods for labeling oligonucleotides.

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56. Prakash, Thazha P.; Seth, Punit P.; Swayze, Eric E., Compositions and methods for modulating HBV expression.

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57. Hoge, Stephen G.; de Fougerolles, Antonin; Ellsworth, Jeff Lynn, Compositions and methods of altering cholesterol levels.

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58. Allerson, Charles; Bhat, Balkrishen; Eldrup, Anne B.; Manoharan, Muthiah; Griffey, Richard H.; Baker, Brenda F.; Swayze, Eric E., Compositions comprising alternating 2'-modified nucleosides for use in gene modulation.

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59. Allerson, Charles; Bhat, Balkrishen; Eldrup, Anne B.; Manoharan, Muthiah; Griffey, Richard H.; Baker, Brenda F.; Swayze, Eric E., Compositions comprising alternating 2′-modified nucleosides for use in gene modulation.

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60. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression ApoB.

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61. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of DGAT2.

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62. Bhanot, Sanjay; Geary, Richard; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of GCCR.

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63. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of GCGR.

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64. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of SGLT2.

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65. Bhat, Balkrishen; Xia, Jie; Seth, Punit P.; Vasquez, Guillermo; Migawa, Michael T.; Allerson, Charles; Prakash, Thazha P.; Swayze, Eric E., Compounds and methods for synthesis of bicyclic nucleic acid analogs.

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66. Capaldi,Daniel C.; Gaus,Hans Joachim Josef; Rentel,Claus Andre Frank; Olsen,Philip Dmitri; Kurata,Christine C.; Song,Quanlai, Compounds and methods for the characterization of oligonucleotides.

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67. Richard H. Griffey ; Douglas L. Cole ; Vasulinga Ravikumar, Compounds for the Synthesis of Nucleotide or oligonucleotide phosphoramidites.

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68. Richard H. Griffey ; Douglas L. Cole ; Vasulinga Ravikumar, Compounds for the synthesis of nucleotide or oligonucleotide phosphoramidites.

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69. Manoharan Muthiah ; Maier Martin A., Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds.

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70. Muthiah Manoharan ; Martin A. Maier, Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds.

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71. Bennett, C. Frank; McKay, Robert; Monia, Brett P.; Baker, Brenda F.; Sioufi, Namir, Conjugates for use in hepatocyte free uptake assays.

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72. Verthelyi, Daniela; Beaucage, Serge L.; Grajkowski, Andrzej, CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods.

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73. Wood, Bradford J.; Dreher, Matthew; Negussie, Ayele H., Cyclized NGR peptide compounds, compositions, and methods of their use.

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74. Seth, Punit P.; Swayze, Eric E., Cyclohexenyl nucleic acids analogs.

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75. Seth, Punit P.; Swayze, Eric E., Cyclohexenyl nucleic acids analogs.

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76. de Fougerolles, Antonin; Wood, Kristy M.; Elbashir, Sayda M.; Schrum, Jason P., DLIN-KC2-DMA lipid nanoparticle delivery of modified polynucleotides.

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77. Brandis, John; Bloom, Curtis; Richards, John H., DNA polymerases having improved labeled nucleotide incorporation properties.

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78. De Fougerolles, Antonin; Elbashir, Sayda M., Delivery and formulation of engineered nucleic acids.

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79. de Fougerolles, Antonin; Elbashir, Sayda M., Delivery and formulation of engineered nucleic acids.

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80. Smith Lloyd M. (South Pasadena CA) Fung Steven (Palo Alto CA), Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for t.

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81. Cole, Douglas L.; Ravikumar, Vasulinga, Diribonucleoside Phosphoramidites.

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82. Baker, Brenda F.; Kraynack, Bryan A., Double stranded constructs comprising one or more short strands hybridized to a longer strand.

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83. Cook, Zhihong C.; Medrano, Leonard, Early light-induced protein promoters.

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84. Bancel, Stephane; Schrum, Jason P.; Aristarkhov, Alexander, Engineered nucleic acids and methods of use thereof.

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85. Bancel, Stephane; Schrum, Jason P.; Aristarkhov, Alexander, Engineered nucleic acids and methods of use thereof.

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86. Schrum, Jason P.; Bancel, Stephane; Afeyan, Noubar B., Engineered nucleic acids and methods of use thereof.

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87. Schrum, Jason P.; Bancel, Stephane; Afeyan, Noubar B.; Ejebe, Kenechi, Engineered nucleic acids and methods of use thereof.

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88. Schrum, Jason P.; Bancel, Stephane; Afeyan, Noubar B.; Ejebe, Kenechi, Engineered nucleic acids and methods of use thereof.

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89. Schrum, Jason P.; Bancel, Stéphane; Afeyan, Noubar B., Engineered nucleic acids and methods of use thereof.

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90. Schrum, Jason P.; Sieczkiewicz, Gregory J.; Ejebe, Kenechi; Elbashir, Sayda M., Engineered nucleic acids and methods of use thereof.

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91. Schrum, Jason P.; Afeyan, Noubar B.; Sieczkiewicz, Gregory J.; Bancel, Stephane; de Fougerolles, Antonin; Elbashir, Sayda M., Engineered nucleic acids encoding a modified erythropoietin and their expression.

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92. Shepard, H. Michael; Chan, Ming Fai; Groziak, Michael P., Enzyme catalyzed therapeutic activation.

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93. Shepard, H. Michael; Groziak, Michael P., Enzyme catalyzed therapeutic agents.

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94. Shepard, H. Michael; Chan, Ming Fai; Groziak, Michael P., Enzyme catalyzed therapeutic compounds.

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95. de Fougerolles, Antonin; Wood, Kristy M.; Valencia, Pedro, Formulation and delivery of PLGA microspheres.

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96. de Fougerolles, Antonin; Wood, Kristy M.; Valencia, Pedro, Formulation and delivery of PLGA microspheres.

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97. Sanghvi, Yogesh S.; Manoharan, Muthiah, Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages.

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98. Manoharan, Muthiah; Cook, Phillip Dan; Prakash, Thazha P.; Mohan, Venkatraman, Guanidinium functionalized intermediates.

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99. Manoharan, Muthiah; Cook, Phillip Dan; Prakash, Thazha P.; Mohan, Venkatraman, Guanidinium functionalized nucleotides and precursors thereof.

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100. Manoharan, Muthiah; Cook, Phillip Dan; Prakash, Thazha P.; Mohan, Venkatraman, Guanidinium functionalized oligonucleotides and method/synthesis.

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101. Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Elbashir, Sayda M.; John, Matthias; Roy, Atanu; Whoriskey, Susan; Wood, Kristy M.; Hatala, Paul; Schrum, Jason P.; Ejebe, Kenechi; Ellsworth, Jeff Lynn; Guild, Justin, In vivo production of proteins.

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102. Cheruvallath, Zacharia S.; Ravikumar, Vasulinga T.; Cole, Douglas L., Intermediates for the synthesis of oligonucleotide analogues.

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103. Manoharan, Muthiah; Guzaev, Andrei P., Labeled oligonucleotides, methods for making same, and compounds useful therefor.

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104. Wan, W. Brad; Migawa, Michael T.; Oestergaard, Michael; Swayze, Eric E.; Seth, Punit P., Linkage modified oligomeric compounds.

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105. Koester Hubert (Concord MA) Coull James M. (Acton MA), Membranes with bound oligonucleotides and peptides.

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106. Kumagai Monto H. ; della-Cioppa Guy R., Method for conferring herbicide, pest, or disease resistance in plant hosts.

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107. Dellinger,Douglas J; Sierzchala,Agnieszka B.; Caruthers,Marvin H; Dellinger,Geraldine F, Method for polynucleotide synthesis.

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108. Adamo, Ilaria; Dueymes, Cecile; Schonberger, Andreas; Imbach, Jean-Louis; Meyer, Albert; Morvan, Francois; Debart, Francoise; Vasseur, Jean-Jacques; Lange, Meinolf; Link, Fritz, Method for preparing oligonucleotides.

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109. de Fougerolles, Antonin; Wood, Kristy M.; Elbashir, Sayda M.; Schrum, Jason P., Method for producing a protein of interest in a primate.

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110. Chreng, Dana, Method for solution phase detritylation of oligomeric compounds.

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111. Pieken Wolfgang ; McGee Danny ; Settle Alecia ; Zhai Yansheng ; Huang Jianping, Method for solution phase synthesis of oligonucleotides.

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112. Migawa, Michael T.; Yu, Jinghua; Wan, W. Brad; Patel, Satyen P.; Vasquez, Guillermo; Kinberger, Garth A.; Prakash, Thazha P.; Seth, Punit P.; Swayze, Eric E., Method for synthesis of reactive conjugate clusters.

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113. Griffey Richard H. ; Cole Douglas L. ; Ravikumar Vasulinga, Method for the synthesis of nucleotide or oligonucleotide phosphoramidites.

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114. Griffey Richard H. ; Cole Douglas L. ; Ravikumar Vasulinga T., Method for the synthesis of nucleotide or oligonucleotide phosphoramidites.

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115. Wada, Takeshi; Shimizu, Mamoru, Method for the synthesis of phosphorus atom modified nucleic acids.

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116. Wada, Takeshi; Shimizu, Mamoru, Method for the synthesis of phosphorus atom modified nucleic acids.

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117. Monto H. Kumagai ; Guy R. della-Cioppa ; Robert L. Erwin ; David R. McGee, Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation.

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118. Dellinger, Douglas J; Dellinger, Geraldine F; Hargreaves, John S, Method of polynucleotide synthesis using modified support.

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119. Cedillo, Isaiah E.; Janczak, Darren; Weaver, Phillip Michael, Method of preparing oligomeric compounds using modified capping protocols.

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120. Cedillo, Isaiah E.; Migawa, Michael T.; Wan, W. Brad, Method of preparing oligomeric compounds using modified coupling protocols.

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121. Alessandra Eleuteri ; Daniel C. Capaldi ; Vasulinga T. Ravikumar, Method of preparing phosphoramidites.

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122. Cole Douglas L. ; Ravikumar Vasulinga, Method of synthesizing phosphorothioate oligonucleotides.

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123. Douglas L. Cole ; Vasulinga Ravikumar, Method of synthesizing phosphorothioate oligonucleotides.

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124. Achim H. Krotz ; Bethany M. McElroy ; Anthony N. Scozzari, Methods for removing dimethoxytrityl groups from oligonucleotides.

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125. Krotz, Achim H.; McElroy, Bethany M.; Scozzari, Anthony N., Methods for removing dimethoxytrityl groups from oligonucleotides.

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126. Krotz,Achim H.; Ravikumar,Vasulinga T., Methods for synthesis of oligonucleotides.

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127. Muthiah Manoharan, Methods for the preparation of conjugated oligomers.

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128. Verdine, Gregory L.; Meena; Iwamoto, Naoki; Butler, David Charles Donnell, Methods for the synthesis of functionalized nucleic acids.

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129. Shepard,H. Michael, Methods for treating therapy-resistant tumors.

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130. Prakash, Thazha P.; Seth, Punit P.; Manoharan, Muthiah; Swayze, Eric E.; Rajeev, Kallanthottathil G.; Zlatev, Ivan, Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom.

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131. Prakash, Thazha P.; Seth, Punit P.; Swayze, Eric E., Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom.

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132. Prakash, Thazha P.; Seth, Punit P.; Swayze, Eric E., Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom.

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133. Schrum, Jason P.; Siddiqi, Suhaib; Ejebe, Kenechi, Modified nucleosides, nucleotides, and nucleic acids, and uses thereof.

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134. Schrum, Jason P.; Siddiqi, Suhaib; Ejebe, Kenechi, Modified nucleosides, nucleotides, and nucleic acids, and uses thereof.

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135. Schrum, Jason P.; Siddiqi, Suhaib; Ejebe, Kenechi, Modified nucleosides, nucleotides, and nucleic acids, and uses thereof.

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136. de Fougerolles, Antonin; Roy, Atanu; Schrum, Jason P.; Siddiqi, Suhaib; Hatala, Paul; Bancel, Stephane, Modified nucleosides, nucleotides, and nucleic acids, and uses thereof.

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137. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides encoding SIAH E3 ubiquitin protein ligase 1.

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138. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides encoding apoptosis inducing factor 1.

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139. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides encoding aquaporin-5.

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140. Chakraborty, Tirtha; de Fougerolles, Antonin; Weiss, Ron, Modified polynucleotides encoding aryl hydrocarbon receptor nuclear translocator.

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141. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides encoding basic helix-loop-helix family member E41.

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142. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides encoding citeD4.

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143. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides encoding copper metabolism (MURR1) domain containing 1.

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144. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides encoding granulysin.

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145. Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Whoriskey, Susan; Weiss, Ron, Modified polynucleotides encoding hepatitis A virus cellular receptor 2.

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146. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides encoding septin-4.

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147. de Fougerolles, Antonin; Wood, Kristy M.; Elbashir, Sayda M.; Schrum, Jason P., Modified polynucleotides for the production of G-CSF.

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148. Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Elbashir, Sayda M.; John, Matthias; Roy, Atanu; Whoriskey, Susan; Wood, Kristy M.; Hatala, Paul; Schrum, Jason P.; Ejebe, Kenechi; Ellsworth, Jeff Lynn; Guild, Justin, Modified polynucleotides for the production of biologics and proteins associated with human disease.

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149. Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Elbashir, Sayda M.; John, Matthias; Roy, Atanu; Whoriskey, Susan; Wood, Kristy M.; Hatala, Paul; Schrum, Jason P.; Ejebe, Kenechi; Ellsworth, Jeff Lynn; Guild, Justin, Modified polynucleotides for the production of biologics and proteins associated with human disease.

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150. Bancel, Stephane; Huang, Eric Yi-Chun, Modified polynucleotides for the production of cosmetic proteins and peptides.

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151. Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Elbashir, Sayda M.; John, Matthias; Roy, Atanu; Whoriskey, Susan; Wood, Kristy M.; Hatala, Paul; Schrum, Jason P.; Ejebe, Kenechi; Ellsworth, Jeff Lynn; Guild, Justin, Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins.

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152. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins.

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153. Chakraborty, Tirtha; de Fougerolles, Antonin; Weiss, Ron, Modified polynucleotides for the production of nuclear proteins.

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154. Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Elbashir, Sayda M.; John, Matthias; Roy, Atanu; Whoriskey, Susan; Wood, Kristy M.; Hatala, Paul; Schrum, Jason P.; Ejebe, Kenechi; Ellsworth, Jeff Lynn; Guild, Justin, Modified polynucleotides for the production of oncology-related proteins and peptides.

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155. Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Elbashir, Sayda M.; Ellsworth, Jeff Lynn; Ejebe, Kenechi; Guild, Justin; John, Matthias; Hatala, Paul; Roy, Atanu; Schrum, Jason P.; Whoriskey, Susan; Wood, Kristy M., Modified polynucleotides for the production of proteins.

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156. Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Elbashir, Sayda M.; John, Matthias; Roy, Atanu; Whoriskey, Susan; Wood, Kristy M.; Hatala, Paul; Schrum, Jason P.; Ejebe, Kenechi; Ellsworth, Jeff Lynn; Guild, Justin, Modified polynucleotides for the production of proteins.

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157. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders.

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158. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders.

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159. Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Elbashir, Sayda M.; John, Matthias; Roy, Atanu; Whoriskey, Susan; Wood, Kristy M.; Hatala, Paul; Schrum, Jason P.; Ejebe, Kenechi; Ellsworth, Jeff Lynn; Guild, Justin, Modified polynucleotides for the production of proteins associated with human disease.

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160. Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Elbashir, Sayda M.; John, Matthias; Roy, Atanu; Whoriskey, Susan; Wood, Kristy M.; Hatala, Paul; Schrum, Jason P.; Ejebe, Kenechi; Ellsworth, Jeff Lynn; Guild, Justin, Modified polynucleotides for the production of secreted proteins.

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161. Chakraborty, Tirtha; de Fougerolles, Antonin, Modified polynucleotides for the production of secreted proteins.

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162. Chakraborty, Tirtha; de Fougerolles, Antonin; Weiss, Ron, Modified polynucleotides for treating galactosylceramidase protein deficiency.

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163. Chakraborty, Tirtha; de Fougerolles, Antonin; Weiss, Ron, Modified polynucleotides for treating protein deficiency.

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164. Rusconi, Christopher P., Modulators of coagulation factors with enhanced stability.

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165. Van Gelder,Russell N.; Von Zastrow,Mark E.; Barchas,Jack D.; Eberwine,James H., Multi-gene expression profile.

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166. Van Gelder Russell N. ; Von Zastrow Mark E. ; Barchas Jack D. ; Eberwine James D., Multi-genes expression profile.

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167. Beaucage, Serge L.; Wilk, Andrzej; Grajkowski, Andrzej, N-acylphosphoramidites and their use in oligonucleotide synthesis.

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168. Prakash, Thazha P.; Bhat, Balkrishin; Swayze, Eric E., N-substituted-aminomethylene bridged bicyclic nucleic acid analogs.

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169. Mock Graham A. (Northborough MA) Lovern Douglas H. (Milford MA), N⁴-substituted 2′-deoxycytidine compounds, oligonucleotides including N⁴-labeled 2′-deoxyc.

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170. Hu, A-Li W.; Hartley, James L.; Jordan, Heather J., Nucleic acid ladders.

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171. Jordan, Heather J., Nucleic acid ladders.

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172. Verdine, Gregory L.; ., Meena; Iwamoto, Naoki, Nucleic acid prodrugs and methods of use thereof.

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173. Engelhardt, Dean; Rabbani, Elazar; Kline, Stanley; Stavrianopoulos, Jannis G.; Kirtikar, Dollie, Nucleic acid sequencing processes using non-radioactive detectable modified or labeled nucleotides or nucleotide analogs, and other processes for nucleic acid detection and chromosomal characterization using such non-radioactive detectable modified or labeled nucleotides or nucleotide analogs.

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174. Caruthers Marvin H. (Boulder CO) Brill Wolfgang K. D. (Schopfheim DEX) Yau Eric (Mercer Island WA) Ma Michael (New York NY) Nielsen John (Horsholm DKX), Nucleoside thiophosphoramidites.

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175. Ravikumar, Vasulinga T.; Capaldi, Daniel C.; Cole, Douglas L., Oligomer phosphoramidite compositions and processes for synthesizing the same.

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176. Swayze, Eric E.; Bhat, Balkrishen; Lima, Walter F.; Prakash, Thazha P.; Kinberger, Garth A., Oligomeric compounds and methods.

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177. Swayze, Eric E.; Bhat, Balkrishen; Lima, Walter F.; Prakash, Thazha P.; Kinberger, Garth A., Oligomeric compounds and methods.

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178. Oestergaard, Michael; Swayze, Eric E.; Seth, Punit P., Oligomeric compounds comprising alpha-beta-constrained nucleic acid.

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179. Swayze, Eric E.; Siwkowski, Andrew M.; Seth, Punit P.; Prakash, Thazha P., Oligomeric compounds comprising tricyclic nucelosides and methods for their use.

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180. Swayze, Eric E.; Siwkowski, Andrew M.; Seth, Punit P.; Prakash, Thazha P., Oligomeric compounds comprising tricyclic nucelosides and methods for their use.

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181. Swayze, Eric E.; Siwkowski, Andrew M.; Seth, Punit P.; Prakash, Thazha P., Oligomeric compounds comprising tricyclic nucleosides and methods for their use.

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182. Seth, Punit P.; Swayze, Eric E., Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside.

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183. Cook,Phillip Dan; Manoharan,Muthiah, Oligonucleolotides having site specific chiral phosphorothioate internucleoside linkages.

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184. Moore,Max N.; Andrade,Mark; Carty,Recaldo; Scozzari,Anthony; Krotz,Achim, Oligonucleotide synthesis with alternative solvents.

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185. Phillip Dan Cook ; Muthiah Manoharan, Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages.

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186. Crooke, Stanley T., Oligoribonucleotides and ribonucleases for cleaving RNA.

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187. Von Der Mülbe, Florian; Hoerr, Ingmar; Pascolo, Steve, Pharmaceutical composition containing a stabilised mRNA optimised for translation in its coding regions.

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188. Guzaev Andrei P. ; Manoharan Muthiah, Phosphate and thiophosphate protecting groups.

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189. Guzaev, Andrei P.; Manoharan, Muthiah, Phosphate and thiophosphate protecting groups.

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190. Shepard,H. Michael; Vaino,Andrew Rein; Lehsten,Danielle M., Phosphoramidate compounds and methods of use.

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191. Guzaev, Andrei Pavel; Vvedenskiy, Vladimir Y., Phosphoramidite building blocks for sugar-conjugated oligonucleotides.

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192. Imbach Jean-Louis,FRX ; Gosselin Gilles,FRX ; Rayner Bernard,FRX, Phosphotriester oligonucleotides, amidites and method of preparation.

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193. Imbach Jean-Louis,FRX ; Gosselin Gilles,FRX ; Rayner Bernard,FRX ; Manoharan Muthiah, Phosphotriester oligonucleotides, amidities and method of preparation.

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194. Caruthers Marvin H. (Boulder CO) Brill Wolfgang K.-D. (Schopfheim DEX) Yau Eric (Mercer Island WA) Ma Michael (New York NY) Nielsen John (Horsholm DKX), Polynucleotide phosphorodithioate compounds.

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195. Bhat, Balkrishen; Swayze, Eric E.; Prakash, Thazha P.; Allerson, Charles; Dande, Prasad; Griffey, Richard H., Positionally modified siRNA constructs.

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196. Dellinger,Douglas J.; Sierzchala,Agnieszka B.; Caruthers,Marvin H., Precursors for two-step polynucleotide synthesis.

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197. Just George,CAX ; Xin Zhili ; Marsault Eric,CAX ; Jin Yi,CAX ; Wang Jianchao,CAX ; Manoharan Muthiah, Preparation of phosphorothioate and boranophosphate oligomers.

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198. George Just CA; Zhili Xin ; Eric Marsault CA; Yi Jin CA; Jianchao Wang CA, Preparation of phosphorothioate oligomers.

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199. Just George,CAX ; Xin Zhili,CAX ; Marsault Eric,CAX ; Jin Yi,CAX, Preparation of phosphorothioate oligomers.

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200. Just George,CAX ; Xin Zhili,CAX ; Marsault Eric,CAX ; Jin Yi,CAX, Preparation of phosphorothioate oligomers.

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201. Just, George; Xin, Zhili; Marsault, Eric; Jin, Yi, Preparation of phosphorothioate oligomers.

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202. Just, George; Xin, Zhili; Marsault, Eric; Jin, Yi; Wang, Jianchao, Preparation of phosphorothioate oligomers.

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203. Scozzari Anthony, Process for oligonucleotide synthesis.

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204. Ishido Yoshiharu (Tokyo JPX) Kamaike Kazuo (Tokyo JPX), Process for synthesis of oligonucleotides and compound for forming polymeric protecting group.

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205. Capaldi Daniel C. ; Ravikumar Vasulinga T., Process for the synthesis of oligomeric compounds.

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206. Capaldi Daniel C. ; Ravikumar Vasulinga T., Process for the synthesis of oligomeric compounds.

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207. Cheruvallath Zacharia S. ; Ravikumar Vasulinga T. ; Cole Douglas L., Process for the synthesis of oligomeric compounds.

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208. Cheruvallath, Zacharia S.; Ravikumar, Vasulinga T.; Cole, Douglas L., Process for the synthesis of oligomeric compounds.

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209. Ravikumar Vasulinga T., Process for the synthesis of oligomeric compounds.

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210. Ravikumar, Vasulinga T.; Manoharan, Muthiah; Capaldi, Daniel C.; Krotz, Achim; Cole, Douglas L.; Guzaev, Andrei, Process for the synthesis of oligomeric compounds.

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211. Ravikumar,Vasulinga T.; Manoharan,Muthiah; Capaldi,Daniel C.; Krotz,Achim; Cole,Douglas L.; Guzaev,Andrei, Process for the synthesis of oligomeric compounds.

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212. Ravikumar,Vasulinga T.; Manoharan,Muthiah; Capaldi,Daniel C.; Krotz,Achim; Cole,Douglas L.; Guzaev,Andrei, Process for the synthesis of oligomeric compounds.

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213. Ravikumar,Vasulinga T.; Manoharan,Muthiah; Capaldi,Daniel C.; Krotz,Achim; Cole,Douglas L.; Guzaev,Andrei, Process for the synthesis of oligomeric compounds.

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214. Ravikumar,Vasulinga; Manoharan,Muthiah; Capaldi,Daniel C.; Krotz,Achim; Cole,Douglas L.; Guzaev,Andrei P., Process for the synthesis of oligomeric compounds.

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215. Vasulinga T. Ravikumar ; Muthiah Manoharan ; Daniel C. Capaldi ; Achim Krotz ; Douglas L. Cole ; Andrei Guzaev, Process for the synthesis of oligomeric compounds.

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216. Zacharia S. Cheruvallath ; Vasulinga T. Ravikumar ; Douglas L. Cole, Process for the synthesis of oligomeric compounds.

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217. Ravikumar Vasulinga T., Process for the synthesis of oligomeric phosphite, phosphodiester, phosphorothioate and phosphorodithioate compounds.

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218. Leuck, Michael; Wolter, Andreas; Stumpe, Alfred, Process for the synthesis of oligonucleotides.

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219. Klem Robert E. ; Marvin William B. ; Riley Timothy A., Process for the synthesis of oligonucleotides and analogs with low water oxidation step.

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220. Ross,Bruce; Song,Quanlai, Process of purifying phosphoramidites.

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221. Manoharan Muthiah, Processes for the synthesis of oligomeric compounds.

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222. Ravikumar, Vasulinga T.; Capaldi, Daniel C.; Cole, Douglas L., Processes for the synthesis of oligomers using phosphoramidite compositions.

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223. Manoharan, Muthiah; Guzaev, Andrei, Processes for the synthesis of oligonucleotide compounds.

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224. Portereiko, Michael F.; Alexandrov, Nickolai, Promoter, promoter control elements, and combinations, and uses thereof.

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225. Portereiko, Michael F.; Alexandrov, Nickolai, Promoter, promoter control elements, and combinations, and uses thereof.

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226. Cheruvallath Zacharia S. ; Capaldi Daniel C. ; Ravikumar Vasulinga T. ; Cole Douglas L., Protecting group for synthesizing oligonucleotide analogs.

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227. Cheruvallath Zacharia S. ; Capaldi Daniel C. ; Ravikumar Vasulinga T. ; Cole Douglas L., Protecting group for synthesizing oligonucleotide analogs.

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228. Cheruvallath Zacharia S. ; Capaldi Daniel C. ; Ravikumar Vasulinga T. ; Cole Douglas L., Protecting group for synthesizing oligonucleotide analogs.

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229. Song,Quanlai; Ross,Bruce S., Protection of nucleosides.

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230. Cheruvallath Zacharia S. ; Ravikumar Vasulinga T. ; Cole Douglas L. ; Capaldi Daniel C., Reagent useful for synthesizing sulfurized oligonucleotide analogs.

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231. Cheruvallath Zacharia S. ; Ravikumar Vasulinga T. ; Cole Douglas L. ; Capaldi Daniel C., Reagent useful for synthesizing sulfurized oligonucleotide analogs.

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232. Zacharia S. Cheruvallath ; Vasulinga T. Ravikumar ; Douglas L. Cole ; Daniel C. Capaldi, Reagent useful for synthesizing sulfurized oligonucleotide analogs.

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233. Nelson, Paul S.; Mackie, Hugh; Murphy, Andrew, Reagents utilizing a serinol scaffold for labeling synthetic oligonucleotides.

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234. Sanghvi Yogesh S. ; Guo Zhiqiang, Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis.

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235. Chiarello, Ronald H.; Liu, Wing; Yokobata, Kathy E., Rhodamine-based fluorophores useful as labeling reagents.

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236. Myers,Andrew G.; Plowright,Alleyn T., Saframycins, analogues and uses thereof.

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237. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Short antisense compounds with gapmer configuration.

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238. Hatala, Paul J.; Kurz, Markus, Solid support reagents for synthesis.

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239. de Fougerolles, Antonin; Elbashir, Sayda M., Split dose administration.

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240. Seth, Punit P.; Prakash, Thazha P.; Swayze, Eric E., Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom.

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241. Prakash, Thazha P.; Swayze, Eric E., Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom.

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242. Seth, Punit P.; Swayze, Eric E., Substituted alpha-L-bicyclic nucleosides.

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243. Moore, Max; Krotz, Achim H.; Andrade, Mark; Scozzari, Anthony N., Synthesis of oligonucleotides on solid support.

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244. Dellinger,Douglas J.; Perbost,Michael G. M.; Caruthers,Marvin H.; Betley,Jason R., Synthesis of polynucleotides using combined oxidation/deprotection chemistry.

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245. Chu, Chi-Yuan; Lee, Wei-Der; Li, Wensen; Hwang, Chan Kou, Synthesis of β-nucleosides.

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246. Manoharan, Muthiah; Guzaev, Andrei, Synthetic methods and intermediates for triester oligonucleotides.

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247. Smith Lloyd M. ; Hood Leroy E. ; Hunkapiller Michael W. ; Hunkapiller Tim J. ; Connell Charles R., Tagged extendable primers and extension products.

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248. Smith, Lloyd M.; Hood, Leroy E.; Hunkapiller, Michael W.; Hunkapiller, Timothy; Connell, Charles R., Tagged extendable primers and extension products.

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249. Chakraborty, Tirtha; Bancel, Stephane; Hoge, Stephen G.; Roy, Atanu; de Fougerolles, Antonin; Afeyan, Noubar B., Terminally modified RNA.

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250. Prakash, Thazha P.; Swayze, Eric E., Tetrahydropyran nucleic acid analogs.

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251. Swayze, Eric E.; Siwkowski, Andrew M.; Bhat, Balkrishen; Prakash, Thazha P.; Allerson, Charles; Seth, Punit P., Tetrahydropyran nucleic acid analogs.

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252. Swayze, Eric E.; Siwkowski, Andrew M.; Bhat, Balkrishen; Prakash, Thazha P.; Allerson, Charles; Seth, Punit P., Tetrahydropyran nucleic acid analogs.

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253. Swayze, Eric E.; Siwkowski, Andrew M.; Bhat, Balkrishen; Prakash, Thazha P.; Allerson, Charles; Seth, Punit P., Tetrahydropyran nucleic acid analogs.

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254. Swayze, Eric E.; Siwkowski, Andrew M.; Bhat, Balkrishen; Prakash, Thazha P.; Allerson, Charles; Seth, Punit P., Tetrahydropyran nucleic acid analogs.

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255. Beaucage, Serge L; Chmielewski, Marcin K, Thermolabile hydroxyl protecting groups and methods of use.

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256. Beaucage,Serge L.; Grajkowski,Andrzej; Wilk,Andrzej, Thermolabile hydroxyl protecting groups and methods of use.

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257. Beaucage, Serge L.; Wilk, Andrzej; Grajkowski, Andrzej, Thermolabile phosphorus protecting groups, associated intermediates and methods of use.

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258. Bolchakova, Elena; Rozzelle, James, Thermus brockianus nucleic acid polymerases.

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259. Bolchakova, Elena; Rozzelle, James, Thermus scotoductus nucleic acid polymerases.

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260. Dellinger, Douglas J.; Sierzchala, Agnieszka B.; Turner, John; Myerson, Joel; Kupihar, Zoltan; Ferreira, Fernando; Caruthers, Marvin H.; Dellinger, Geraldine F., Thiocarbon-protecting groups for RNA synthesis.

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261. Dellinger, Douglas J.; Sierzchala, Agnieszka; Turner, John; Myerson, Joel; Kupihar, Zoltan; Ferreira, Fernando; Caruthers, Marvin H.; Dellinger, Geraldine F., Thiocarbon-protecting groups for RNA synthesis.

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262. Seth, Punit P.; Swayze, Eric E.; Hanessian, Stephen; Schroeder, Benjamin R.; Giacometti, Robert D.; Merner, Bradley L., Tricyclic nucleic acid analogs.

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