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Method for the purification of erythropoietin and erythropoietin compositions 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-015/14
  • C07K-003/20
  • A61K-035/22
  • A61K-037/24
출원번호 US-0690853 (1985-01-11)
발명자 / 주소
  • Hewick Rodney M. (Lexington MA) Seehra Jasbir S. (Arlington MA)
출원인 / 주소
  • Genetics Institute, Inc. (Cambridge MA 02)
인용정보 피인용 횟수 : 51  인용 특허 : 10

초록 ▼

A method for purifying erythropoietin is described. The method comprises treating partially purifying erythropoietin by reverse phase high performance liquid chromatography to obtain homogeneous erythropoietin having a molecular weight of about 34,000 daltons on SDS PAGE and moving a single peak on

대표청구항

Homogeneous erythropoietin characterized by a molecular weight of about 34,000 daltons on SDS PAGE, movement as a single peak on reverse phase high performance liquid chromatography and a specific activity of at least 160,000 IU per absorbance unit at 280 nanometers.

이 특허에 인용된 특허 (10)

  1. Egrie, Joan C., A.T.C.C. HB8209 and its monoclonal antibody to erythropoietin.
    상세보기
  2. Rivier Jean E. F. (La Jolla CA), Mobile phase for liquid chromatography.
    상세보기
  3. Goldwasser, Eugene; Kavinsky, Clifford; Weiss, Tania L., Monoclonal anti-erythropoietin.
    상세보기
  4. Takezawa Kenji (Yokohama JPX) Hiratani Hajima (Osaka JPX), Novel erythropoietin product and method for the preparation thereof.
    상세보기
  5. Chiba Hideo (Uji JPX) Sasaki Ryuzo (Kyoto JPX) Ueda Masatsugu (Kawagoe JPX), Process for producing erythropoietin.
    상세보기
  6. Takezawa Kenji (Yokohama JPX) Hiratani Hajime (Osaka JPX), Process for production of erythropoietin.
    상세보기
  7. Sugimoto Kaname (Okayama JPX) Hayashibara Yasushi (Okayama JPX), Process for the production of human erythropoietin.
    상세보기
  8. Pestka Sidney (North Caldwell NJ) Rubinstein Menachem (Rimon ILX), Protein purification process and product.
    상세보기
  9. Fisher James W. (New Orleans LA) Rege Arvind B. (New Orleans LA), Radioimmunoassay for erythropoietin.
    상세보기
  10. Lee-Huang Sylvia (345 E. 69th St. New York NY 10021), Reverse immunoaffinity chromatography purification method.
    상세보기

이 특허를 인용한 특허 (51)

  1. MacLeod, James N., Canine erythropoietin gene and recombinant protein.
    상세보기
  2. MacLeod, James N., Canine erythropoietin gene and recombinant protein.
    상세보기
  3. MacLeod,James N., Canine erythropoietin gene and recombinant protein.
    상세보기
  4. Beck Anton K. (Wellesley MA) Withy Raymond M. (Framingham MA) Zabrecky James R. (Framingham MA) Masiello Nicholas C. (Milford MA), Cell encoding recombinant human erythropoietin.
    상세보기
  5. Wrighton Nicholas C. ; Dower William J. ; Chang Ray S. ; Kashyap Arun K. ; Jolliffe Linda K. ; Johnson Dana ; Mulcahy Linda, Compounds and peptides that bind to the erythropoietin receptor.
    상세보기
  6. Dowd, Jason Everett; Weik, Robert; Hemetsberger, Thomas, Enhanced liquid formulation stability of erythropoietin alpha through purification processing.
    상세보기
  7. Sytkowski Arthur J. ; Grodberg Jennifer, Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics.
    상세보기
  8. Duliege, Anne Marie; Stead, Richard; Leuther, Kerstin; Woodburn, Kathryn; Naso, Robert Barnett, Erythropoietin receptor peptide formulations and uses.
    상세보기
  9. Duliege, Anne-Marie; Stead, Richard; Leuther, Kerstin; Woodburn, Kathryn Wynne; Naso, Robert Barnett, Erythropoietin receptor peptide formulations and uses.
    상세보기
  10. Mizushima, Hidefumi; Yoshimori, Takayuki, Erythropoietin solution preparation.
    상세보기
  11. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., High throughput chemical handling system.
    상세보기
  12. Carcagno, Carlos Miguel; Criscuolo, Marcelo Eduardo; Melo, Carlos Alberto; Vidal, Juan Alejandro, Host cells expressing recombinant human erythropoietin.
    상세보기
  13. Aebischer Patrick,CHX ; Deglon Nicole,CHX ; Regulier Etienne,CHX ; Rinsch Christopher,CHX, Hypoxia responsive EPO producing cells.
    상세보기
  14. Wang Elizabeth A., Isolated native primate GM-CSF protein.
    상세보기
  15. Christopher Bentley Shumate ; Peter J. Coassin, Liquid chemical distribution method and apparatus.
    상세보기
  16. Carcagno, Carlos Miguel; Criscuolo, Marcelo Eduardo; Melo, Carlos Alberto; Vidal, Miguel Alejandro, Method for the massive culture of cells producing recombinant human erythropoietin.
    상세보기
  17. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., Methods for rapidly identifying useful chemicals in liquid sample.
    상세보기
  18. Wrighton Nicholas C. ; Dower William J. ; Chang Ray S. ; Kashyap Arun K., Methods of administering peptides that bind to the erythropoietin receptor.
    상세보기
  19. Kampinga, Jaap; Alcock, Robert A., Methods of terminal sterilization of fibrinogen.
    상세보기
  20. Guyon, Thierry; Borrelly, Gilles; Gallet, Xavier; Drittanti, Lila; Vega, Manuel, Modified erythropoietin polypeptides and uses thereof for treatment.
    상세보기
  21. Sytkowski Arthur J., Modified polypeptides with altered biological activity.
    상세보기
  22. Sytkowski Arthur J., Modified polypeptides with altered biological activity.
    상세보기
  23. Sytkowski Arthur J., Modified polypeptides with increased biological activity.
    상세보기
  24. Balu, Palani, Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use.
    상세보기
  25. Balu,Palani, Peptide dimers as agonists of the erythropoietin (EPO) receptor, and associated methods of synthesis and use.
    상세보기
  26. Holmes, Christopher P.; Yin, Qun; Lalonde, Guy; Schatz, Peter J.; Tumelty, David; Balu, Palani; Zemede, Genet, Peptides that bind to the erythropoietin receptor.
    상세보기
  27. Holmes, Christopher P.; Yin, Qun; Lalonde, Guy; Schatz, Peter J.; Tumelty, David; Balu, Palani; Zemede, Genet, Peptides that bind to the erythropoietin receptor.
    상세보기
  28. Holmes, Christopher P.; Yin, Qun; Lalonde, Guy; Schatz, Peter J.; Tumelty, David; Palani, Balu; Zemede, Genet, Peptides that bind to the erythropoietin receptor.
    상세보기
  29. Holmes, Christopher P.; Yin, Qun; Lalonde, Guy; Schatz, Peter J.; Tumelty, David; Palani, Balu; Zemede, Genet, Peptides that bind to the erythropoietin receptor.
    상세보기
  30. Holmes,Christopher P.; Yin,Qun; Lalonde,Guy; Schatz,Peter J.; Tumelty,David; Palani,Balu; Zemede,Genet, Peptides that bind to the erythropoietin receptor.
    상세보기
  31. Holmes,Christopher P.; Yin,Qun; Lalonde,Guy; Schatz,Peter J.; Tumelty,David; Palani,Balu; Zemede,Genet, Peptides that bind to the erythropoietin receptor.
    상세보기
  32. Wrighton Nicholas C. ; Dower William J. ; Chang Ray S. ; Kashyap Arun K., Peptides that bind to the erythropoietin receptor.
    상세보기
  33. Lin Fu-Kuen, Production of erthropoietin.
    상세보기
  34. Lin Fu-Kuen (Thousand Oaks CA), Production of erythropoietin.
    상세보기
  35. Lin Fu-Kuen (Thousand Oaks CA), Production of erythropoietin.
    상세보기
  36. Negulescu Paul ; Offermanns Stefan,DEX ; Simon Melvin ; Zuker Charles, Promiscuous G-protein compositions and their use.
    상세보기
  37. Stamatoyannopoulos George (Seattle WA), Pulse treatment of hemoglobinopathies with erythropoietin.
    상세보기
  38. Delcuve Genevieve,CAX, Recombinant DNA molecules and expression vectors for erythropoietin.
    상세보기
  39. Sytkowski Arthur J. ; Grodberg Jennifer,CAX, Recombinant human erythropoietin mutants.
    상세보기
  40. Arthur J. Sytkowski ; Jennifer Grodberg CA, Recombinant human erythropoietin with altered biological activity.
    상세보기
  41. Kararli, Tugrul T.; Nema, Sandeep; Karim, Aziz, Reconstitutable parenteral composition.
    상세보기
  42. Holmes, Christopher P.; Tumelty, David; Yin, Qun, Spacer moiety for poly(ethylene glycol) modified peptide based compounds.
    상세보기
  43. Sutcliffe J. Gregor (Cardiff CA), Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods.
    상세보기
  44. Sutcliffe J. Gregor, Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same.
    상세보기
  45. Chari Stylli ; Samuel S. Beckey ; Christopher Bentley Shumate ; Peter J. Coassin, Systems and methods for rapidly identifying useful chemicals in liquid samples.
    상세보기
  46. Chari Stylli ; Samuel S. Beckey ; Christopher Bentley Shumate ; Peter J. Coassin, Systems and methods for rapidly identifying useful chemicals in liquid samples.
    상세보기
  47. Stylli Chari ; Beckey Samuel S. ; Shumate Christopher Bentley ; Coassin Peter J., Systems and methods for rapidly identifying useful chemicals in liquid samples.
    상세보기
  48. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., Systems and methods for rapidly identifying useful chemicals in liquid samples.
    상세보기
  49. Rex, Tonia S.; Sullivan, Timothy A., Therapeutic compositions and methods for disorders associated with neuronal degeneration.
    상세보기
  50. Russell-Jones Gregory John,AUX ; Westwood Steven William,AUX, Vitamin B.sub.12 mediated oral delivery systems for GCSF.
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  51. Russell-Jones Gregory John,AUX ; Westwood Steven William,AUX, Vitamin B12 conjugates with gcsf, analogues thereof and pharmaceutical compositions.
    상세보기

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