초록 ▼

The instant invention is directed to a lipid osmotic pump, comprising: (A) a core, comprising: (i) a beneficial amount of at least one substantially water insoluble active agent which is lipid soluble and/or lipid wettable; (ii) a sufficient amount of at least one water immiscible lipid carrier, whi

The instant invention is directed to a lipid osmotic pump, comprising: (A) a core, comprising: (i) a beneficial amount of at least one substantially water insoluble active agent which is lipid soluble and/or lipid wettable; (ii) a sufficient amount of at least one water immiscible lipid carrier, which is liquid at the temperature of intended use, to dissolve and/or suspend said active agent; and (iii) a sufficient amount of at least one osmotic agent to ensure release of said lipid carrier from the pump; and (B) surrounded by a water insoluble wall: (i) having a thickness of about 1 to 1000 microns; (ii) which is preferentially wetted by said lipid carrier over an aqueous solution of said osmotic agent; (iii) having a water permeability of about 1×10-18 to 4×10-15 cm3 sec/g; (iv) prepared from at least one polymer permeable to water but substantially impermeable to said osmotic agent; and (v) having a means for said active agent and lipid carrier to be released through said water insoluble wall.

대표청구항 ▼

A lipid osmotic pump, for the controlled delivery of a substantially water insoluble active agent into an aqueous environment, comprising: (A) a core, comprising an admixture of: (i) a beneficial amount of at least one substantially water insoluble active agent which is lipid soluble and/or lipid w

A lipid osmotic pump, for the controlled delivery of a substantially water insoluble active agent into an aqueous environment, comprising: (A) a core, comprising an admixture of: (i) a beneficial amount of at least one substantially water insoluble active agent which is lipid soluble and/or lipid wettable; (ii) a sufficient amount of at least one water immiscible lipid carrier, which is liquid at the temperature of intended use, to dissolve and/or suspend said active agent; and (iii) a sufficient amount of at least one osmotic agent to ensure release of said lipid carrier from the pump; and (B) surrounded by a water insoluble wall; (i) having a thickness of about 1 to 1000 microns; (ii) which is preferentially wetted by said lipid carrier over an aqueous solution of said osmotic agent; (iii) having a water permeability of about 1×10-18 to 4×10-15 cm3 sec/g; (iv) prepared from atleast some polymer permeable to waster but substantially impermeable to said osmotic agent; and (v) having a means for said active agent to be released through said water insoluble wall; (C) wherein at the temperature of use, the lipid carrier is liquid and retains the lipid soluble or lipid wettable agent in a dissolved or suspended state so that upon the dissolution of the osmotic agent in the imbibed water the lipid carrier and the dissolved or suspended active agent is released from the osmotic pump at a controlled rate.