초록 ▼

Novel compounds, compositions and pharmaceutical a method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprising administering an effective, 5-lipoxygenase pathway inhibiting amount of a 4,5-diaryl-2(substituted)-imidazole or a pharmaceutically acceptable salt thereof

Novel compounds, compositions and pharmaceutical a method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprising administering an effective, 5-lipoxygenase pathway inhibiting amount of a 4,5-diaryl-2(substituted)-imidazole or a pharmaceutically acceptable salt thereof.

대표청구항 ▼

A compound of the formula [Figure] wherein: X1 is NHCN or NH2; R1 and R are independently selected from 4-pyridyl or monosubstituted phenyl wherein said substituent is selected from halo or C1-4 alkoxy; and Y1 is H or CN provided that when X1 is NH2, Y1 is CN when X1 is NHCN, Y1 is H; or a pharmaceu

A compound of the formula [Figure] wherein: X1 is NHCN or NH2; R1 and R are independently selected from 4-pyridyl or monosubstituted phenyl wherein said substituent is selected from halo or C1-4 alkoxy; and Y1 is H or CN provided that when X1 is NH2, Y1 is CN when X1 is NHCN, Y1 is H; or a pharmaceutically acceptable salt thereof. A method for treating rheumatoid arthritis in an animal in need thereof which comprises administering to such animal an effective, non-toxic 5-lipoxygenase pathway inhibiting amount of a compound of the formula [Figure] wherein: X1 is NHCN or NH2; R1 and R are independently selected from 4-pyridyl or monosubstituted phenyl wherein said substituent is selected from halo or C1-4 alkoxy; and Y1 is H or CN provided that when X1 is NH2, Y1 is CN and when X1 is NHCN, Y1 is H; or a pharmaceutically acceptable salt thereof.