초록 ▼

Drug preparations for external application having a stick-itself-to-the-skin property, so-called “soft patch”, are provided. The preparations contain a drug, a water-soluble protein having an absorption-promoting effect, a polyhydric alcohol a tackifier, and an oleaginous substance, and ensure an im

Drug preparations for external application having a stick-itself-to-the-skin property, so-called “soft patch”, are provided. The preparations contain a drug, a water-soluble protein having an absorption-promoting effect, a polyhydric alcohol a tackifier, and an oleaginous substance, and ensure an improved percutaneous absorption and bioavailability of the drugs, thus permitting an accurate control of drug dosage.

대표청구항 ▼

In the art of externally applying drug preparations to the skin, which act as a barrier to the absorption of the drug, the improvement which comprises externally contacting the skin with a soft drug preparation containing a percutaneously absorbable drug, applied either topically, directly to the ef

In the art of externally applying drug preparations to the skin, which act as a barrier to the absorption of the drug, the improvement which comprises externally contacting the skin with a soft drug preparation containing a percutaneously absorbable drug, applied either topically, directly to the effected site, or in the neighborhood thereof, for the purpose of curing disease on the skin surface, or under the skin, or to systematically reach a target tissue or organ, when absorbed from the skin surface where applied, at a site which is most conductive to the percutaneous absorption of the active components of the drug preparation and where a horny layer is not well developed, said drug preparation exhibiting a stick-itself-to-the-skin property and containing the following components: (a) a percutaneously absorbable drug; (b) a water-soluble protein having an absorption promoting effect in an amount which ranges from 5 to 15 weight percent based on the weight of the whole composition; (c) a polyhydric alcohol in an amount which ranges from 5 to 50 weight percent based on the weight of the whole composition; (d) a tackifier in an amount which ranges from 0.1 to 15 weight percent based on the weight of the whole composition; and (e) an oleaginous substance in an amount which ranges from 0.1 to 25 weight percent based on the weight of the whole composition.