초록 ▼

A pharmaceutical tablet which releases an initial burst of therapeutic agent and thereafter releases the agent at an essentially constant rate comprising an acid soluble therapeutic agent in an insoluble matrix, the tablet containing an acid insoluble, base soluble pharmaceutically acceptable compon

A pharmaceutical tablet which releases an initial burst of therapeutic agent and thereafter releases the agent at an essentially constant rate comprising an acid soluble therapeutic agent in an insoluble matrix, the tablet containing an acid insoluble, base soluble pharmaceutically acceptable component selected from polymers and fatty acids, a pharmaceutically acceptable organic acid and at least one pharmaceutically acceptable excipient, the component and the acid each being present in an amount of from about 1-25 percent by weight of the total composition.

대표청구항 ▼

A pharmaceutical tablet which releases an initial burst of therapeutic agent and thereafter releases said agent at an essentially constant rate comprising an acid-soluble therapeutic agent, an acid-insoluble, base-soluble pharmaceutically acceptable polymeric acid phthalate, and a pharmaceutically a

A pharmaceutical tablet which releases an initial burst of therapeutic agent and thereafter releases said agent at an essentially constant rate comprising an acid-soluble therapeutic agent, an acid-insoluble, base-soluble pharmaceutically acceptable polymeric acid phthalate, and a pharmaceutically acceptable polycarboxylic acid in an insoluble matrix consisting of ethyl cellulose, hydrogenated vegetable oil or mixtures thereof, said phthalate being present in an amount of from about 1 to 25 percent by weight of said tablet, said acid being present in an amount of from about 7 to 20% by weight of said tablet, said matrix components being present in an amount of from about 2-10% by weight of said tablet and said therapeutic agent being present in an amount of from about 25-75% by weight of said tablet.