초록 ▼

Compositions and methods for maintaining reservoirs of bioactive agents by sequestering the reservoir in a gel matrix are described. In particular, liposomes containing an entrapped bioactive agent are sequestered in a gel matrix. The resulting liposome-gel compositions may be used in vivo or in vit

Compositions and methods for maintaining reservoirs of bioactive agents by sequestering the reservoir in a gel matrix are described. In particular, liposomes containing an entrapped bioactive agent are sequestered in a gel matrix. The resulting liposome-gel compositions may be used in vivo or in vitro to provide for sustained release of the bioactive agent. The gel matrix inhibits the dispersion and clearance of the sequestered liposomes without interfering with the ability of the liposomes to release the entrapped bioactive agent. Furthermore, the rate of release of the bioactive agent from the liposome-gel compositions may be varied by altering the composition of the liposomes and/or gels.

대표청구항 ▼

A liposome-gel composition comprising a bioactive agent entrapped in liposomes sequestered in a gel matrix in which: (a) the gel matrix has a pore size relative to the liposomes so that the liposomes are sequestered in the gel matrix without blocking (i) diffusion of fluids into the gel which intera

A liposome-gel composition comprising a bioactive agent entrapped in liposomes sequestered in a gel matrix in which: (a) the gel matrix has a pore size relative to the liposomes so that the liposomes are sequestered in the gel matrix without blocking (i) diffusion of fluids into the gel which interact with bilayers of the liposomes, (ii) the ability of the sequestered liposomes to release the entrapped bioactive agent or (iii) the diffusion of the bioactive agent released from the liposomes through the gel to the surrounding environment; and (b) the gel matrix is capable of forming or remaining gelled at temperatures and conditions of the environment in which it is administered or applied.