초록 ▼

Plastic articles having enhanced antithrombogenic activity due to the presence of hydrophobic materials attached to amine compounds bonded on the surface of the plastic which repel bonded antithrom bogenic agents outwardly from the plastic surface, making them more readily available to the blood for

Plastic articles having enhanced antithrombogenic activity due to the presence of hydrophobic materials attached to amine compounds bonded on the surface of the plastic which repel bonded antithrom bogenic agents outwardly from the plastic surface, making them more readily available to the blood for subsequent thrombus inhibition.

대표청구항 ▼

A process for imparting improved antithrombogenic activity to a polymeric support surface, which comprises: (a) coating the polymeric support surface with an amine-rich material selected from the group consisting of a primary amine having a carbon chain length of 2 to 10,000, a polyalkylenimine havi

A process for imparting improved antithrombogenic activity to a polymeric support surface, which comprises: (a) coating the polymeric support surface with an amine-rich material selected from the group consisting of a primary amine having a carbon chain length of 2 to 10,000, a polyalkylenimine having 2 to 4 carbon atoms per amine unit and mixtures thereof to give an amine rich surface. (b) plasma-treating said amine-rich surface and a gaseous material in an ionization chamber whereby hydrophobic groups generated from said gaseous material are introduced to said amine-rich surface to give a hydrophobic amine-rich surface; and (c) covalently bonding an antithrombogenic agent to said hydrophobic amine-rich material.