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[미국특허] Derivative of the tryptophan operon for expression of fused gene products 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12P-021/00
  • C12P-021/02
  • C12N-015/00
  • C12N-001/20
  • C12N-007/00
  • C07H-015/12
출원번호 US-0655183 (1984-09-27)
발명자 / 주소
  • Belagaje Ramamoorthy (Indianapolis IN) Epp Janet K. (Indianapolis IN) Hoskins JoAnn (Indianapolis IN) Hsiung Hansen M. (Indianapolis IN) Long George L. (Indianapolis IN) Schoner Brigitte E. (Zionsvil
출원인 / 주소
  • Eli Lilly and Company (Indianapolis IN 02)
인용정보 피인용 횟수 : 91  인용 특허 : 0

초록 ▼

The present invention comprises improved derivatives of the tryptophan operon useful for expressing fused gene products in E. coli and relate organism. Two of the improved derivatives disclosed are encoded on 0.43 and 0.55 kb EcoRI restriction fragments from plasmids pCZ20 and pLEBGH2 (in strains NR

대표청구항 ▼

In the derivative of the tryptophan operon promoter-operator-leader sequence wherein said sequence comprises a transcriptional activating sequence, a transitional activating sequence and a DNA coding region for a fused leader-trpE gene sequence from which the sequence encoding the carboxy terminus o

이 특허를 인용한 특허 (91)

  1. Krstenansky John L. (Palo Alto CA) Nestor ; Jr. John J. (Cupertino CA) Vickery Brian H. (Mountain View CA), Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporo.
    상세보기
  2. Krstenansky John L. ; Nestor ; Jr. John J. ; Ho Teresa H. ; Vickery Brian H. ; Bach Chinh T., Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis.
    상세보기
  3. Cho, Ho Sung; Daniel, Thomas O.; Wilson, Troy E.; Cujec, Thomas P.; Tian, Feng; Hays, Anna Maria; Kimmel, Bruce E.; Ho, Lillian, Antigen-binding polypeptides and their uses.
    상세보기
  4. Cho, Ho Sung; Daniel, Thomas O.; Wilson, Troy E.; Cujec, Thomas P.; Tian, Feng; Hays, Anna-Maria A.; Kimmel, Bruce E.; Ho, Lillian, Antigen-binding polypeptides and their uses.
    상세보기
  5. Cho, Ho Sung; Daniel, Thomas O.; Hays, Anna Maria; Wilson, Troy E.; Litzinger, David C.; Mariani, Roberto; Kimmel, Bruce E.; Keefe, William M., Biosynthetic polypeptides utilizing non-naturally encoded amino acids.
    상세보기
  6. Paulsel, Andrew; Cho, Ho Sung, Compositions of aminoacyl-tRNA synthetase and uses thereof.
    상세보기
  7. Paulsel, Andrew; Cho, Ho Sung, Compositions of aminoacyl-tRNA synthetase and uses thereof.
    상세보기
  8. Paulsel, Andrew; Cho, Ho Sung, Compositions of aminoacyl-tRNA synthetase and uses thereof.
    상세보기
  9. Paulsel, Andrew; Cho, Ho Sung, Compositions of aminoacyl-tRNA synthetase and uses thereof.
    상세보기
  10. Paulsel, Andrew; Cho, Ho Sung, Compositions of aminoacyl-tRNA synthetase and uses thereof.
    상세보기
  11. Tian, Feng, Compositions of tRNA and uses thereof.
    상세보기
  12. Wong Edith (Chesterfield MO) Bittner Michael L. (Naperville IL), DNA comprising lamb secretion signal sequence and mature IGF-1 sequence.
    상세보기
  13. Lowe Peter Anthony (Reading GBX), DNA encoding lipase from human gastric mucosal tissue.
    상세보기
  14. Ratti Giulio,ITX, DNA molecules encoding pgp3 protein from Chlamydia trachomatis.
    상세보기
  15. Ratti,Giulio, Detection of antibodies againstpgp3 antigen in patient sera by enzyme-linked immunoassay.
    상세보기
  16. Schultz Jody ; Hermanson Gary, Expression vectors.
    상세보기
  17. Hays, Anna-Maria A.; Buechler, Ying; Litzinger, David C., Formulations of human growth hormone comprising a non-naturally encoded amino acid.
    상세보기
  18. Hays, Anna-Maria; Buechler, Ying; Litzinger, David C., Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35.
    상세보기
  19. Cho, Ho Sung; Daniel, Thomas O.; DiMarchi, Richard D.; Hays, Anna-Maria; Wilson, Troy E.; Sim, Bee-Cheng; Litzinger, David C., Human growth hormone modified at position 35.
    상세보기
  20. Tian, Feng; Norman, Thea; Chu, Stephanie, Hybrid suppressor tRNA for vertebrate cells.
    상세보기
  21. Burton, Louis E.; Schmelzer, Charles H.; Beck, Joanne T., Isolation of neurotrophins from a mixture containing neurotrophin variants using hydrophobic interaction chromatography.
    상세보기
  22. Burton, Louis E.; Schmelzer, Charles H.; Beck, Joanne T., Isolation of neurotrophins from a mixture containing other proteins and neurotrophin variants using hydrophobic interaction chromatography.
    상세보기
  23. Louis E. Burton ; Charles H. Schmelzer ; Joanne T. Beck, Isolation of neurotrophins from a mixture containing other proteins and neurotrophin variants using hydrophobic interaction chromatography.
    상세보기
  24. Lowe Peter Anthony,GBX, Lipase from human gastric mucosal tissue.
    상세보기
  25. Andersen, Dana; Joly, John; Snedecor, Bradley R., Metabolic rate shifts in fermentations expressing recombinant proteins.
    상세보기
  26. Wagner, Fred W.; Luan, Peng; Xia, Yuannan; Strydom, Daniel; Seo, Jin Seog, Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides.
    상세보기
  27. Wagner, Fred W.; Luan, Peng; Xia, Yuannan; Strydom, Daniel; Seo, Jin Seog, Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides.
    상세보기
  28. Cho Joong M. (Seoul KRX) Lee Tae H. (Daejeon KRX) Chung Hyun H. (Seoul KRX) Lee Yong B. (Daejeon KRX) Lee Tae G. (Seoul KRX) Park Young W. (Daejeon KRX) Han Kyu B. (Daejeon KRX), Method for the production of salmon growth hormone using a synthetic gene.
    상세보기
  29. Wagner,Fred W.; Luan,Peng; Xia,Yuannan; Strydom,Daniel; Merrifield,Edwin H.; Bossard,Mary J.; Holmquist,Barton; Seo,Jin Seog, Method for universal enzymatic production of bioactive peptides.
    상세보기
  30. Wagner,Fred W.; Luan,Peng; Xia,Yuannan; Strydom,Daniel; Merrifield,Edwin H.; Bossard,Mary J.; Holmquist,Barton; Seo,Jin Seog, Method for universal enzymatic production of bioactive peptides.
    상세보기
  31. Bussineau Christopher M. ; Dorin Glenn ; Kudrna Robert D., Method of improved production of insulin-like growth factor.
    상세보기
  32. Kraynov, Vadim; Knudsen, Nick; Hewet, Amha; De Dios, Kristine; Pinkstaff, Jason; Sullivan, Lorraine, Method of treating heart failure with modified relaxin polypeptides.
    상세보기
  33. Miao, Zhenwei; Tian, Feng; Hays Putnam, Anna-Maria A.; Buechler, Ying, Methods and compositions comprising non-natural amino acids.
    상세보기
  34. Buechler, Ying; Lieu, Ricky; Ong, Michael; Bussell, Stuart; Knudsen, Nick; Cho, Ho Sung, Methods for expression and purification of recombinant human growth hormone.
    상세보기
  35. Ernst, James A.; Yansura, Daniel; Kim, Hok Seon, Methods for producing soluble membrane spanning proteins.
    상세보기
  36. Ernst, James A.; Yansura, Daniel; Kim, Hok Seon, Methods for producing soluble membrane-spanning proteins.
    상세보기
  37. Ernst, James A.; Yansura, Daniel; Kim, Hok Seon, Methods for producing soluble membrane-spanning proteins.
    상세보기
  38. Ernst, James A.; Yansura, Daniel; Kim, Hok Seon, Methods for producing soluble membrane-spanning proteins.
    상세보기
  39. Cujec, Thomas P.; Mariani, Roberto; Hays Putnam, Anna-Maria A.; Keefe, William M.; Knudsen, Nick; Skidmore (Nee Ho), Lillian; Pinkstaff, Jason; Kraynov, Vadim, Methods of making FGF-21 mutants comprising non-naturally encoded phenylalanine derivatives.
    상세보기
  40. Cujec, Thomas P.; Mariani, Roberto; Hays Putnam, Anna-Maria A.; Keefe, Wiliam M.; Knudsen, Nick; Skidmore, Lillian; Pinkstaff, Jason; Kraynov, Vadim, Methods of treatment using modified FGF-21 polypeptides comprising non-naturally occurring amino acids.
    상세보기
  41. Cujec, Thomas P.; Mariani, Roberto; Hays Putnam, Anna-Maria A.; Keefe, William M.; Knudsen, Nick; Ho, Lillian; Pinkstaff, Jason; Kraynov, Vadim, Modified FGF-21 polypeptides and their uses.
    상세보기
  42. Morin, Paul E.; Cohen, Daniel; Mukherjee, Ranjan; Reilly, Timothy P.; Christian, Rose C.; Lipovsek, Dasa; Camphausen, Ray; Krupinski, John, Modified FGF-21 polypeptides comprising an internal deletion and uses thereof.
    상세보기
  43. Morin, Paul E.; Cohen, Daniel; Mukherjee, Ranjan; Reilly, Timothy P.; Christian, Rose C.; Lipovsek, Dasa; Camphausen, Ray; Krupinski, John, Modified FGF-21 polypeptides comprising an internal deletion and uses thereof.
    상세보기
  44. Cujec, Thomas P.; Mariani, Roberto; Hays Putnam, Anna-Maria A.; Keefe, William M.; Knudsen, Nick; Ho, Lillian; Pinkstaff, Jason; Kraynov, Vadim, Modified FGF-21 polypeptides comprising non-naturally occurring amino acids.
    상세보기
  45. Tian, Feng; Hays Putnam, Anna-Maria A.; Song, Frank; Chu, Stephanie; Sheffer, Joseph; Barnett, Richard S.; Siladi, Marc E.; Atkinson, Kyle; Lee, Darin; Canning, Peter C., Modified animal erythropoietin polypeptides and their uses.
    상세보기
  46. Tian, Feng; Hays Putnam, Anna-Maria A.; Song, Frank; Chu, Stephanie; Sheffer, Joseph; Barnett, Richard S.; Siladi, Marc; Atkinson, Kyle; Lee, Darin; Canning, Peter C., Modified animal erythropoietin polypeptides and their uses.
    상세보기
  47. Tian, Feng; Hays Putnam, Anna-Maria A.; Song, Frank; Chu, Stephanie; Sheffer, Joseph; Barnett, Richard S.; Siladi, Marc; Atkinson, Kyle; Lee, Darin; Canning, Peter C., Modified animal erythropoietin polypeptides and their uses.
    상세보기
  48. Tian, Feng; Hays Putnam, Anna-Maria A.; Song, Frank; Chu, Stephanie; Sheffer, Joseph; Barnett, Richard S.; Siladi, Marc; Atkinson, Kyle; Lee, Darin; Canning, Peter C., Modified animal erythropoietin polypeptides and their uses.
    상세보기
  49. Hays Putnam, Anna-Maria A.; Knudsen, Nick; Norman, Thea; Koder, Alan; Kraynov, Vadim; Ho, Lillian; Canning, Peter C., Modified bovine G-CSF polypeptides and their uses.
    상세보기
  50. Cho, Ho Sung; Daniel, Thomas O.; DiMarchi, Richard D.; Hays, Anna-Maria; Wilson, Troy E.; Sim, Bee-Cheng; Litzinger, David C., Modified human four helical bundle polypeptides and their uses.
    상세보기
  51. Cho, Ho Sung; Daniel, Thomas O.; DiMarchi, Richard D.; Hays, Anna-Maria; Wilson, Troy E.; Sim, Bee-Cheng; Litzinger, David C., Modified human four helical bundle polypeptides and their uses.
    상세보기
  52. Cho, Ho Sung; Daniel, Thomas O.; Dimarchi, Richard D.; Hays, Anna-Maria A.; Wilson, Troy E.; Sim, Bee-Cheng; Litzinger, David C., Modified human four helical bundle polypeptides and their uses.
    상세보기
  53. Cho, Ho Sung; Daniel, Thomas O.; DiMarchi, Richard D.; Hays, Anna-Maria A.; Wilson, Troy E.; Sim, Bee-Cheng; Litzinger, David C., Modified human growth hormone.
    상세보기
  54. Hays, Anna-Maria; Buechler, Ying; Litzinger, David C., Modified human growth hormone formulations with an increased serum half-life.
    상세보기
  55. Cho, Ho Sung; Daniel, Thomas O.; Hays Putnam, Anna-Maria A.; Wilson, Troy E., Modified human interferon polypeptides and their uses.
    상세보기
  56. Cho, Ho Sung; Daniel, Thomas O.; Hays, Anna-Maria; Wilson, Troy E., Modified human interferon polypeptides and their uses.
    상세보기
  57. Cho, Ho Sung; Daniel, Thomas O.; Hays, Anna-Maria A.; Wilson, Troy E., Modified human interferon polypeptides with at least one non-naturally encoded amino acid and their uses.
    상세보기
  58. Sheffer, Joseph; Norman, Thea; Dimarchi, Richard D.; Hays Putnam, Anna-Maria A.; Tian, Feng; Chu, Stephanie; Krawitz, Denise; Cho, Ho Sung, Modified human plasma polypeptide or Fc scaffolds and their uses.
    상세보기
  59. Sheffer, Joseph; Norman, Thea; Dimarchi, Richard D.; Hays Putnam, Anna-Maria A.; Tian, Feng; Chu, Stephanie; Krawitz, Denise; Cho, Ho Sung, Modified human plasma polypeptide or Fc scaffolds and their uses.
    상세보기
  60. Sheffer, Joseph; Norman, Thea; Dimarchi, Richard D.; Hays Putnam, Anna-Maria A.; Tian, Feng; Chu, Stephanie; Krawitz, Denise; Cho, Ho Sung, Modified human plasma polypeptide or Fc scaffolds and their uses.
    상세보기
  61. Miao, Zhenwei; Krawitz, Denise; Kraynov, Vadim; Tian, Feng; Sim, Bee-Cheng; Skidmore, Lillian; Hays Putnam, Anna-Maria A.; Knudsen, Nick; Deguzman, Michael, Modified insulin polypeptides and their uses.
    상세보기
  62. Kraynov, Vadim; Knudsen, Nick; Hays Putnam, Anna-Maria A.; Krawitz, Denise; Pinkstaff, Jason; Myler, Heather, Modified interferon beta polypeptides and their uses.
    상세보기
  63. Kraynov, Vadim; Hays Putnam, Anna-Maria A.; Knudsen, Nick; Pinkstaff, Jason; Myler, Heather; Sullivan, Lorraine, Modified leptin polypeptides and their uses.
    상세보기
  64. Tian, Feng; Hehli, Brad, Non-natural amino acid replication-dependent microorganisms and vaccines.
    상세보기
  65. Tian, Feng; Hehli, Brad, Non-natural amino acid replication-dependent microorganisms and vaccines.
    상세보기
  66. Cujec, Thomas P.; Mariani, Roberto; Hays Putnam, Anna-Maria A.; Keefe, William M.; Knudsen, Nick; Skidmore, Lillian; Pinkstaff, Jason; Kraynov, Vadim, Nucleic acids encoding modified FGF-21 polypeptides comprising non-naturally occurring amino acids.
    상세보기
  67. Kraynov, Vadim; Knudsen, Nick; Hewet, Ahma; De Dios, Kristine; Pinkstaff, Jason; Sullivan, Lorraine, Nucleic acids encoding modified relaxin polypeptides.
    상세보기
  68. Hays, Anna-Maria A.; Kimmel, Bruce E.; Cho, Ho Sung; Sim, Bee-Cheng; Litzinger, David C.; Mariani, Roberto; Kraynov, Vadim; Knudsen, Nick; Daniel, Thomas O.; Koder, Alan; Bussell, Stuart; Liu, Junjie; Miao, Zhenwei; Morrow, Theresa, Pegylated human interferon polypeptides.
    상세보기
  69. Piazza Christin Teresa ; Radomsky Michael Lloyd ; Krstenansky John Leonard ; Nestor ; Jr. John Joseph ; Vickery Brian Henry, Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis.
    상세보기
  70. Sasaki, Ken; Williamson, Vanessa Jane; Araujo, Alberto de; Walczyk, Ewa, Production of glucagon-like peptide 2.
    상세보기
  71. Hunter,Christie L.; Botti,Paolo; Bradburne,James A.; Chen,Shiah yun; Cressman,Sonya; Kent,Stephen B. H.; Kochendoerfer,Gerd G.; Low,Donald W., Pseudo native chemical ligation.
    상세보기
  72. Burton Louis E. ; Schmelzer Charles H. ; Beck Joanne T., Purification of NGF.
    상세보기
  73. Fahrner Robert Lee ; Reifsnyder David, Purification of molecules.
    상세보기
  74. Burton Louis E. ; Schmelzer Charles H. ; Beck Joanne T., Purification of recombinant human neurotrophins.
    상세보기
  75. Ratti, Giulio, Recombinant Chlamydia trachomatis PGP3 antigen.
    상세보기
  76. Ratti,Giulio, Recombinantpgp3 protein suitable for enzyme-linked immunoassay, and used of the protein in eliciting and diagnosing an immune response.
    상세보기
  77. Builder Stuart (Belmont CA) Hart Roger (Burlingame CA) Lester Philip (San Lorenzo CA) Reifsnyder David (San Mateo CA), Refolding of misfolded insulin-like growth factor-I.
    상세보기
  78. Kraynov, Vadim; Knudsen, Nick; Hewet, Ahma; De Dios, Kristine; Pinkstaff, Jason; Sullivan, Lorraine, Relaxin polypeptides comprising non-naturally encoded amino acids.
    상세보기
  79. Kraynov, Vadim; Knudsen, Nick; Hewet, Ahma; De Dios, Kristine; Pinkstaff, Jason; Sullivan, Lorraine, Relaxin polypeptides comprising non-naturally encoded amino acids.
    상세보기
  80. Wong Edith ; Bittner Michael L., Secretion of insulin-like growth factor-I in E. coli.
    상세보기
  81. Tian, Feng; Norman, Thea; Chu, Stephanie, Suppressor tRNA transcription in vertebrate cells.
    상세보기
  82. Krstenansky John L. ; Nestor John J. ; Ho Teresa H. ; Vickery Brian H. ; Bach Chinh T., Synthesis and use for the treatment of osteoporosis.
    상세보기
  83. Morin, Paul E.; Cohen, Daniel; Mukherjee, Ranjan; Reilly, Timothy P.; Christian, Rose C.; Lipovsek, Dasa; Camphausen, Ray; Krupinski, John, Therapeutic uses of modified FGF-21 polypeptides.
    상세보기
  84. Kraynov, Vadim; Knudsen, Nick; Hewet, Amha; De Dios, Kristine; Pinkstaff, Jason; Sullivan, Lorraine, Therapeutic uses of modified relaxin polypeptides.
    상세보기
  85. Kraynov, Vadim; Knudsen, Nick; Hewet, Amha; de Dios, Kristine; Pinkstaff, Jason; Sullivan, Lorraine, Therapeutic uses of modified relaxin polypeptides.
    상세보기
  86. Halloran Philip F.,CAX, Use of insulin-like growth factors I and II for inhibition of inflammatory response.
    상세보기
  87. Halloran Philip F.,CAX, Use of insulin-like growth factors I and II for inhibition of inflammatory response.
    상세보기
  88. Spencer Emerald M. (San Francisco CA) Talkington-Verser Carol (San Rafael CA), Uses for antibodies which bind to human somatomedin carrier protein subunits.
    상세보기
  89. Antoniades Harry N. (Newton MA) Lynch Samuel E. (Jamaica Plain MA) Williams Ray C. (Arlington MA), Wound healing and bone regeneration using PDGF and IGF-I.
    상세보기
  90. Antoniades Harry N. (Newton MA) Lynch Samuel E. (Jamaica Plain MA), Wound healing composition of IGF-I and TGF-b 상세보기
  • Antoniades Harry N. (Newton MA) Lynch Samuel E. (Jamaica Plain MA), Wound healing using PDGF and IGF-II.
    상세보기

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