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Stabilized compositions 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/195
  • A61K-031/40
  • A61K-031/27
  • A61K-031/505
출원번호 US-0017962 (1987-02-24)
발명자 / 주소
  • Harris Michael (Hackettstown NJ) Hokanson Gerard (Long Valley NJ) Murthy Kuchi (Morris Plains NJ) Reisch Robert (Haledon NJ) Waldman Frank (Wayne NJ)
출원인 / 주소
  • Warner-Lambert Company (Morris Plains NJ 02)
인용정보 피인용 횟수 : 74  인용 특허 : 0

초록

The cyclization, hydrolysis, and coloration of certain ACE inhibitors is minimized when they are formulated with a metal-containing stabilizer and a saccharide.

대표청구항

A pharmaceutical composition which contains: (a) a drug component which comprises a suitable amount of an ACE inhibitor which is susceptible to cyclization, hydrolysis, and discoloration, (b) a suitable amount of an alkali or alkaline earth metal carbonate to inhibit cyclization and discoloration, a

이 특허를 인용한 특허 (74)

  1. Himmelsbach, Frank; Langkopf, Elke; Eckhardt, Matthias; Maier, Roland, 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions.
  2. Himmelsbach, Frank; Langkopf, Elke; Eckhardt, Matthias; Maier, Roland, 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions.
  3. Himmelsbach, Frank; Langkopf, Elke; Eckhardt, Matthias; Maier, Roland, 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions.
  4. Himmelsbach, Frank; Langkopf, Elke; Eckhardt, Matthias; Mark, Michael; Maier, Roland; Lotz, Ralf; Tadayyon, Mohammad, 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions.
  5. Himmelsbach, Frank; Langkopf, Elke; Eckhardt, Matthias; Mark, Michael; Maier, Roland; Lotz, Ralf; Tadayyon, Mohammad, 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and thier use as pharmaceutical compositions.
  6. Klein, Thomas; Grempler, Rolf; Mark, Michael, Combination therapy.
  7. Klein, Thomas; Grempler, Rolf; Mark, Michael, Combination therapy.
  8. Klein, Thomas; Grempler, Rolf; Mark, Michael, Combination therapy.
  9. Friedl, Thomas; Braun, Michael; Egusa, Kenji; Fujita, Hikaru; Maruyama, Megumi; Nishioka, Takaaki, DPP-IV inhibitor combined with a further antidiabetic agent, tablets comprising such formulations, their use and process for their preparation.
  10. Friedl, Thomas; Braun, Michael; Egusa, Kenji; Fujita, Hikaru; Maruyama, Megumi; Nishioka, Takaaki, DPP-IV inhibitor combined with a further antidiabetic agent, tablets comprising such formulations, their use and process for their preparation.
  11. Friedl, Thomas; Braun, Michael; Egusa, Kenji; Fujita, Hikaru; Maruyama, Megumi; Nishioka, Takaaki, DPP-IV inhibitor combined with a further antidiabetic agent, tablets comprising such formulations, their use and process for their preparation.
  12. Klein, Thomas; Mark, Michael; Thomas, Leo, Diabetes therapy.
  13. Rajewski, Lian G.; Rajewski, Roger A.; Haslam, John L.; Heppert, Kathleen; Beckloff, Michael C.; Seagrave, Frank; Mauro, Robert; Colabuono, Peter, Enalapril compositions.
  14. Rajewski, Lian G.; Rajewski, Roger A.; Haslam, John L.; Heppert, Kathleen; Beckloff, Michael C.; Segrave, Frank; Mauro, Robert; Colabuono, Peter, Enalapril compositions.
  15. Rajewski, Lian G.; Rajewski, Roger A.; Haslam, John L.; Heppert, Kathleen; Beckloff, Michael C.; Segrave, Frank; Mauro, Robert; Colabuono, Peter, Enalapril compositions.
  16. Rajewski, Lian G.; Rajewski, Roger A.; Haslam, John L.; Heppert, Kathleen; Beckloff, Michael C.; Segrave, Frank; Mauro, Robert; Colabuono, Peter, Enalapril compositions.
  17. Mosher, Gerold L.; Miles, David W., Enalapril formulations.
  18. Mosher, Gerold L.; Miles, David W., Enalapril formulations.
  19. Mosher, Gerold L.; Miles, David W., Enalapril formulations.
  20. Mosher, Gerold L.; Miles, David W., Enalapril formulations.
  21. , Formulations of ramipril.
  22. Mosher, Gerold L.; Miles, David W., Lisinopril formulations.
  23. Mosher, Gerold L.; Miles, David W., Lisinopril formulations.
  24. Mosher, Gerold L.; Miles, David W., Lisinopril formulations.
  25. Mosher, Gerold L.; Miles, David W., Lisinopril formulations.
  26. Klein, Thomas; Advani, Andrew; Connelly, Kim Alexander; Gilbert, Richard Ernest, Medical use of a DPP-4 inhibitor.
  27. Meinicke, Thomas; Von Eynatten, Maximilian, Medical use of pharmaceutical combination or composition.
  28. Klein, Thomas; Mark, Michael, Method for modifying food intake and regulating food preference with a DPP-4 inhibitor.
  29. Cooper, Vincent Brett; Bradley, Kathryn Alanna; Pygall, Samuel Robert; Gupta, Rajan; Stanford, Madison Paige; Xie, Lin, Oral pharmaceutical formulation of omarigliptin.
  30. Ito, Masanori; Egusa, Kenji; Kleinbeck, Kyle; Messerschmid, Roman; Schneider, Peter; Voleti, Venkata, Pharmaceutical composition and uses thereof.
  31. Bauer Brigitte,DEX ; Karlsson Christer,SEX ; Lundberg Per Johan,SEX ; Nilsson Berit,SEX ; Sandberg Anders,SEX ; Sickmuller Alfred,DEX, Pharmaceutical composition containing the ace inhibitor ramipril and a dihydropyridine compound.
  32. Creekmore Joseph R ; Wiggins Norman A., Pharmaceutical compositions.
  33. Creekmore, Joseph R; Wiggins, Norman A., Pharmaceutical compositions.
  34. Sherman, Bernard Charles, Pharmaceutical compositions comprising moexipril magnesium.
  35. Sherman, Bernard Charles, Pharmaceutical compositions comprising quinapril magnesium.
  36. Sieger, Peter; Kemmer, Dirk; Kohlbauer, Peter; Nicola, Thomas; Renz, Martin, Polymorphs.
  37. Sieger, Peter; Kemmer, Dirk; Kohlbauer, Peter; Nicola, Thomas; Renz, Martin, Polymorphs.
  38. Sieger, Peter; Kemmer, Dirk; Kohlbauer, Peter; Nicola, Thomas; Renz, Martin, Polymorphs.
  39. Pfrengle, Waldemar; Pachur, Thorsten; Nicola, Thomas; Duran, Adil, Process for the preparation of chiral 8-(3-aminopiperidin-1-yl)-xanthines.
  40. Pfrengle, Waldemar; Pachur, Thorsten; Nicola, Thomas; Duran, Adil, Process for the preparation of chiral 8-(3-aminopiperidin-1-yl)-xanthines.
  41. Pfrengle, Waldemar; Pachur, Thorsten; Nicola, Thomas; Duran, Adil, Process for the preparation of chiral 8-(3-aminopiperidin-1-yl)-xanthines.
  42. Sieger, Peter; Pfrengle, Waldemar, Salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine.
  43. Sieger, Peter; Pfrengle, Waldemar, Salt forms of a xanthine compound.
  44. Daniel,Jane Ellen; Harris,Michael Ray; Hokanson,Gerard Clifford; Weiss,Jay, Stabilization of quinapril using magnesium oxide.
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  46. Apelian Vahe Henry ; Parikh Nilesh H. ; Iyer Raman, Stabilized pharmaceutical compositions.
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  50. Vivilecchia, Richard V.; Ross, Bruce A., Stabilized pharmaceutical compositions comprising acid donors.
  51. Han Chien-Hsuan ; Liaw Gary, Stabilized pharmaceutical compositions containing bupropion hydrochloride.
  52. Spireas, Spiridon, Stable formulations of ACE inhibitors, and methods for preparation thereof.
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  60. Hagner, Thomas, System and method for internally fitting a new inner hull to an existing outer hull to form a rebuilt double hull vessel.
  61. Drake James Franklin, Topically applied clotting material.
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  65. Dugi, Klaus, Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy comprising a DPP-IV inhibitor.
  66. Dugi, Klaus; Graefe-Mody, Eva Ulrike; Mark, Michael; Woerle, Hans-Juergen; Zimdahl-Gelling, Heike, Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin.
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  69. Klein, Thomas; von Eynatten, Maximilian; Mark, Michael, Use of a DPP-4 inhibitor in podocytes related disorders and/or nephrotic syndrome.
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  73. Klein, Thomas; Daiber, Andreas; Johansen, Odd-Eric; Mark, Michael; Patel, Sanjaykumar; Woerle, Hans-Juergen, Vasoprotective and cardioprotective antidiabetic therapy.
  74. Roth,Bruce, [R-(R*R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, its lactone form and salts thereof.
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