초록 ▼

The invention relates to the use of carboxylic acids incorporated as a catalyst in poly(orthoester)s and other acid labile polymers such that upon exposure to aqueous environments the acid catalyzes the erosion of the polymer matrix. The rate of release of a drug substance incorporated into or surro

The invention relates to the use of carboxylic acids incorporated as a catalyst in poly(orthoester)s and other acid labile polymers such that upon exposure to aqueous environments the acid catalyzes the erosion of the polymer matrix. The rate of release of a drug substance incorporated into or surrounded by the poly(orthoester) or other acid labile polymer can be controlled in that the drug is released as the polymer is eroded in response to the catalytic action of the acid incorporated therein.

대표청구항 ▼

A controlled release device for the delivery of drugs or other biological beneficial substances which comprises: (a) an acid labile polymer, and (b) an erosion catalyzing amount up to a maximum of about 25 percent, by weight, based on (a), of at least one organic carboxylic acid and mixtures thereof

A controlled release device for the delivery of drugs or other biological beneficial substances which comprises: (a) an acid labile polymer, and (b) an erosion catalyzing amount up to a maximum of about 25 percent, by weight, based on (a), of at least one organic carboxylic acid and mixtures thereof selected from the group consisting of 2-fluorostearic acid, 2-fluoropalmitic acid, 2-fluoromyristic acid, 2-nitro-stearic acid, 2,2-difluorostearic acid, 2,3-difluorostearic acid, o-fluorobenzoic acid, p-fluorobenzoic acid, o-nitrobenzoic acid, p-nitrobenzoic acid, p-trifluoromethyl benzoic acid, o-trifluoromethyl benzoic acid, 4-trifluoromethyl-1-naphthoic acid, N-dodecyl phthalamic acid, N-methyl-N-dodecyl phthalamic acid, N-methyl-N-octadecyl phthalamic acid, N-octadecyl phthalamic acid, N-butyl-phthalamic acid, and N-methyl-N-octadecyl-5-nitro-phthalamic acid incorporated within the matrix of said acid labile polymer.