초록 ▼

In addition to the active ingredient, the capsules contain a nonionic surfactant consisting of a polyglycol ester or ether having hydrophilic and lipophilic portions, and an organic polymer which is capable of forming a free-flowing composition with the active ingredient and the surfactant. The esse

In addition to the active ingredient, the capsules contain a nonionic surfactant consisting of a polyglycol ester or ether having hydrophilic and lipophilic portions, and an organic polymer which is capable of forming a free-flowing composition with the active ingredient and the surfactant. The essential point for the delay in release is the matching of the water-solubility of the active ingredient and the hydrophilic/lipophilic character (HLB value) of the surfactant as follows: ________________________________ -water-insoluble HLB value above 16; sparingly soluble HLB value between 10 and 16; and water-soluble HLB value below 10. ________________________________

대표청구항 ▼

A medicament exhibiting a delayed release of active ingredient in the form of hard gelatin capsules which comprises: an active ingredient; a surfactant ingredient which comprises polyglycol ethers, esters of mixtures thereof, which has both hydrophilic and lipophilic portions and is chosen based on

A medicament exhibiting a delayed release of active ingredient in the form of hard gelatin capsules which comprises: an active ingredient; a surfactant ingredient which comprises polyglycol ethers, esters of mixtures thereof, which has both hydrophilic and lipophilic portions and is chosen based on the relative water solubility or water insolubility of said active ingredient, wherein said solubility or insolubility is defined as follows: ________________________________ - Parts of Solvent Required for Solubility 1 Part of Solution ________________________________ very readily soluble less than 1 readily soluble from 1 to 10 soluble from 10 to 30 sparingly soluble from 30 to 100 slightly soluble from 100 to 1000 very slightly soluble from 1000 to 10,000 practically insoluble 10,000 and more, or insoluble ________________________________ said surfactant ingredient having the following hydrophilipophilic balance (HLB) value, above 16 for an active ingredient which is insoluble or slightly soluble in water, between 16 and 10 for an active ingredient which is sparingly soluble in water, and less than 10 for an active ingredient which is soluble in water; and an organic polymer or polymers which form a homogeneous solution or suspension with said active ingredient and said surfactant ingredient, the solution or suspension being in free-flowing form below about 70°C., wherein said active ingredient is in an amount of about 1 to 60%, said surfactant ingredient is in an amount of about 30 to 90% and said organic polymer is in an amount of about 1 to 45% of the weight of the contents of the capsule.