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Monoclonal antibody purification process using protein A 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/395
출원번호 US-0139504 (1987-12-30)
발명자 / 주소
  • Ngo That T. (Irvine CA)
출원인 / 주소
  • Bioprobe International, Inc. (Tustin CA 02)
인용정보 피인용 횟수 : 62  인용 특허 : 1

초록

Immunoglobins are purified by adsorption upon an immobilized protein A adsorbent using a buffer having a pH of 7.5 to 10 and containing a combination of monovalent cations and polybasic anions in a concentration of about 0.6M to 1.75M.

대표청구항 ▼

A process for the purification of immunoglobulins which comprises: mixing a medium containing immunoglobulins with a buffer solution having a pH in the range of about pH 7.5 to pH 10 and containing a combination of monovalent cations and polybasic anions in a concentration of about 0.6M to 1.75M to

이 특허에 인용된 특허 (1)

  1. Ngo That T. (Irvine CA), Method of activating hydroxyl groups of a polymeric carrier using 2-fluoro-1-methylpyridinium toluene-4-sulfonate.
    상세보기

이 특허를 인용한 특허 (62)

  1. Ruike, Yoshinao; Sampei, Zenjiro, Anti-C5 antibodies.
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  2. Ruike, Yoshinao; Kuramochi, Taichi; Muramatsu, Hiroyasu; Ueyama, Atsunori; Igawa, Tomoyuki; Katada, Hitoshi; Hori, Yuji, Anti-myostatin antibodies, polypeptides containing variant Fc regions, and methods of use.
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  3. Igawa, Tomoyuki; Ishii, Shinya; Maeda, Atsuhiko; Nakai, Takashi, Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly.
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  4. Igawa, Tomoyuki; Ishii, Shinya; Maeda, Atsuhiko; Nakai, Takashi, Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly.
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  5. Lin, Shanhua; Pohl, Christopher A., Buffer kit and method of generating a linear pH gradient.
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  6. Subramanian, Kartik; Zeng, Xiaobei; Dong, Diane D.; Lim, Wen Chung; Gifford, Kathreen A.; Chumsae, Christopher, Cell culture methods to reduce acidic species.
    상세보기
  7. Subramanian, Kartik; Zeng, Xiaobei; Dong, Diane D.; Lim, Wen Chung; Gifford, Kathreen A.; Chumsae, Christopher, Cell culture methods to reduce acidic species.
    상세보기
  8. Subramanian, Kartik; Zeng, Xiaobei; Dong, Diane D.; Lim, Wen Chung; Gifford, Kathreen A.; Chumsae, Christopher, Cell culture methods to reduce acidic species.
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  9. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
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  10. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
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  11. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
    상세보기
  12. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
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  13. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
    상세보기
  14. Labkovsky, Boris; Ghayur, Tariq; Gaza-Bulseco, Georgeen; Mishra, Pratibha; Hegde, Subramanya; Krishnan, Sudha, Glycoengineered binding protein compositions.
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  15. Bakker, Alexander Berthold Hendrik; Van Loo, Pieter Fokko, Human CD3 binding antibody.
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  16. Chumsae, Christopher M., Human antibodies that bind human TNF-alpha and methods of preparing the same.
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  17. Chumsae, Christopher M., Human antibodies that bind human TNF-alpha and methods of preparing the same.
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  18. Igawa, Tomoyuki; Maeda, Atsuhiko; Nakamura, Genki; Muraoka, Masaru, IL-8 antibodies.
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  19. Ramasubramanyan, Natarajan; Yang, Lihua; Herigstad, Matthew Omon; Yang, Hong; Chumsae, Christopher, Low acidic species compositions.
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  20. Ramasubramanyan, Natarajan; Yang, Lihua; Herigstad, Matthew Omon; Yang, Hong; Subramanian, Kartik; Zeng, Xiaobei; Dong, Diane D.; Lim, Wen Chung; Gifford, Kathreen A.; Kaymakcalan, Zehra; Chumsae, Christopher, Low acidic species compositions and methods for producing and using the same.
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  21. Ramasubramanyan, Natarajan; Yang, Lihua; Herigstad, Matthew Omon; Yang, Hong; Subramanian, Kartik; Zeng, Xiaobei; Dong, Diane D.; Lim, Wen Chung; Gifford, Kathreen A.; Kaymakcalan, Zehra; Chumsae, Christopher, Low acidic species compositions and methods for producing and using the same.
    상세보기
  22. Ramasubramanyan, Natarajan; Yang, Lihua; Herigstad, Matthew Omon; Yang, Hong; Subramanian, Kartik; Zeng, Xiaobei; Dong, Diane D.; Lim, Wen Chung; Gifford, Kathreen A.; Kaymakcalan, Zehra; Chumsae, Christopher, Low acidic species compositions and methods for producing and using the same.
    상세보기
  23. Ramasubramanyan, Natarajan; Yang, Lihua; Herigstad, Matthew Omon; Yang, Hong; Subramanian, Kartik; Zeng, Xiaobei; Dong, Diane D.; Lim, Wen Chung; Gifford, Kathreen A.; Kaymakcalan, Zehra; Chumsae, Christopher, Low acidic species compositions and methods for producing and using the same.
    상세보기
  24. Ramasubramanyan, Natarajan; Yang, Lihua; Herigstad, Matthew Omon; Yang, Hong; Subramanian, Kartik; Zeng, Xiaobei; Dong, Diane D.; Lim, Wen Chung; Gifford, Kathreen A.; Kaymakcalan, Zehra; Chumsae, Christopher, Low acidic species compositions and methods for producing and using the same.
    상세보기
  25. Ramasubramanyan, Natarajan; Yang, Lihua; Herigstad, Matthew Omon; Yang, Hong; Subramanian, Kartik; Zeng, Xiaobei; Dong, Diane D.; Lim, Wen Chung; Gifford, Kathreen A.; Kaymakcalan, Zehra; Chumsae, Christopher, Low acidic species compositions and methods for producing and using the same.
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  26. Wang, Chen; Coppola, Germano; Chumsae, Chris, Low acidic species compositions and methods for producing and using the same using displacement chromatography.
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  27. Wang, Chen; Coppola, Germano; Chumsae, Chris, Low acidic species compositions and methods for producing and using the same using displacement chromatography.
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  28. Hoogenboom, Hendricus Renerus; Logtenberg, Ton, Method for selecting a single cell expressing a heterogeneous combination of antibodies.
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  29. Romero, Jonathan; Chrostowski, James; De Vilmorin, Philippe Georges; Case, Jennifer Yun, Method of isolating biomacromolecules using low pH and divalent cations.
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  30. De Kruif, Cornelis Adriaan; Hendriks, Linda Johanna Aleida; Logtenberg, Ton, Methods and means for the production of Ig-like molecules.
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  31. Bengea, Cornelia; Rives, Lisa M.; Hossler, Patrick, Methods for controlling the galactosylation profile of recombinantly-expressed proteins.
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  32. Bengea, Cornelia; Rives, Lisa M.; Hossler, Patrick, Methods for controlling the galactosylation profile of recombinantly-expressed proteins.
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  33. Bengea, Cornelia; Rives, Lisa M.; Hossler, Patrick, Methods for controlling the galactosylation profile of recombinantly-expressed proteins.
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  34. Bengea, Cornelia; Rives, Lisa M.; Hossler, Patrick, Methods for controlling the galactosylation profile of recombinantly-expressed proteins.
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  35. Bengea, Cornelia; Rives, Lisa M.; Hossler, Patrick, Methods for controlling the galactosylation profile of recombinantly-expressed proteins.
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  36. Hossler, Patrick; McDermott, Sean; Racicot, Christopher; Correia, Ivan, Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides.
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  37. Ruike, Yoshinao; Sampei, Zenjiro, Methods of neutralizing C5 with anti-C5 antibodies.
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  38. Rives, Lisa M.; Bengea, Cornelia; Zeng, Xiaobei, Methods to control protein heterogeneity.
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  39. Rives, Lisa M.; Bengea, Cornelia; Zeng, Xiaobei, Methods to control protein heterogeneity.
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  40. Rives, Lisa M.; Bengea, Cornelia; Zeng, Xiaobei, Methods to control protein heterogeneity.
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  41. Rives, Lisa M.; Bengea, Cornelia; Zeng, Xiaobei, Methods to control protein heterogeneity.
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  42. Subramanian, Kartik; Perez, Mayda; Zeng, Xiaobei; Wong, Chee Furng; Chumsae, Christopher, Methods to modulate lysine variant distribution.
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  43. Subramanian, Kartik; Thiele, Mayda Perez; Zeng, Xiaobei; Wong, Chee Furng; Chumsae, Christopher M., Methods to modulate lysine variant distribution.
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  44. Logtenberg, Ton; Hoogenboom, Hendricus Renerus Jacobus Mattheus, Mixture of binding proteins.
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  45. Logtenberg, Ton; Hoogenboom, Hendricus Renerus Jacobus Mattheus, Mixtures of binding proteins.
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  46. Subramanian, Kartik; Perez Thiele, Mayda; Zeng, Xiaobei; Wong, Chee Furng; Kaymakcalan, Zehra; Jing, Ying; Chumsae, Christopher, Modulated lysine variant species compositions and methods for producing and using the same.
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  47. Subramanian, Kartik; Thiele, Mayda Perez; Zeng, Xiaobei; Wong, Chee Furng; Kaymakcalan, Zehra; Jing, Ying; Chumsae, Christopher M., Modulated lysine variant species compositions and methods for producing and using the same.
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  48. Chumsae, Chris M.; Kaymakcalan, Zehra, Mutated anti-TNFα antibodies and methods of their use.
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  49. Ramasubramanyan, Natarajan; Yang, Lihua; Herigstad, Matthew Omon; Yang, Hong; Chumsae, Christopher, Protein purification methods to reduce acidic species.
    상세보기
  50. Ramasubramanyan, Natarajan; Yang, Lihua; Herigstad, Matthew Omon; Yang, Hong; Chumsae, Christopher, Protein purification methods to reduce acidic species.
    상세보기
  51. Wang, Chen; Coppola, Germano; Chumsae, Chris, Protein purification using displacement chromatography.
    상세보기
  52. Wang, Chen; Coppola, Germano; Chumsae, Chris, Protein purification using displacement chromatography.
    상세보기
  53. Herigstad, Matthew Omon; Rich, Linda E.; Lu, Stephen Ming-teh; Ramasubramanyan, Natarajan, Purification of antibodies using hydrophobic interaction chromatography.
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  54. Herigstad, Matthew Omon; Rich, Linda E.; Lu, Stephen Ming-teh; Ramasubramanyan, Natarajan, Purification of proteins using hydrophobic interaction chromatography.
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  55. Van Berkel, Patricius H. C.; Brus, Ronald Hendrik; Logtenberg, Ton; Bout, Abraham, Recombinant production of mixtures of antibodies.
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  56. Van Berkel,Patrick H. C.; Brus,Ronald H. P.; Logtenberg,Ton; Bout,Abraham, Recombinant production of mixtures of antibodies.
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  57. Van Berkel,Patrick Hendrikus Cornelis; Bout,Abraham; Logtenberg,Ton; Brus,Ronald Hendrik Pieter, Recombinant production of mixtures of antibodies.
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  58. Ngo That T. (Irvine CA), Synthetic affinity ligand compositions and methods for purification and recovery of organic molecules.
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  59. Igawa, Tomoyuki; Maeda, Atsuhiko; Mimoto, Futa; Kuramochi, Taichi, Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance.
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  60. Ramakrishnan, Vanitha; Bhaskar, Vinay; Ho, Sun; Murray, Richard; Law, Debbie, Use of anti-α5β1 antibodies to inhibit cancer cell proliferation.
    상세보기
  61. Wentz, Alane E.; Hemmavanh, Don; Matuck, Joseph G., Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins.
    상세보기
  62. Leary,Thomas Richard; Lafoe,Daniel, Vegetarian protein a preparation and methods thereof.
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