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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0063925 (1987-06-19) |
발명자 / 주소 |
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출원인 / 주소 |
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인용정보 | 피인용 횟수 : 290 인용 특허 : 1 |
A process and device for quantitative determination of analyte concentrations in liquid samples. The device includes one or more bibulous matrices constructed and arranged to essentially eliminate sample volume sensitivity from analyte determinations. In accordance with the present invention, the de
A process and device for quantitative determination of analyte concentrations in liquid samples. The device includes one or more bibulous matrices constructed and arranged to essentially eliminate sample volume sensitivity from analyte determinations. In accordance with the present invention, the device includes one or more test reagent-treated bibulous matrices covered at least partially by an impermeable coating or film. A liquid sample is applied to the uncovered portion of the bibulous matrix such that the liquid sample is metered into the bibulous matrix by the impermeable coating or film. The sample chromatographs through the bibulous matrix until the matrix is saturated with liquid. The process is essentially sample volume independent, providing more uniform and accurate quantitative analyte determinations.
A device for metering a constant volume of a liquid to an analyte assay area comprising a bibulous matrix having upper and lower major surfaces, the lower major surface disposed against a hydrophobic substrate, and the upper major surface being only partially covered by a liquid impermeable barrier,
A device for metering a constant volume of a liquid to an analyte assay area comprising a bibulous matrix having upper and lower major surfaces, the lower major surface disposed against a hydrophobic substrate, and the upper major surface being only partially covered by a liquid impermeable barrier, said bibulous matrix having a first portion devoid of reagent and a second portion which is reagent impregnated such that liquid applied to an area of the upper bibulous matrix surface spaced from the liquid-impermeable barrier is metered into the first bubulous matrix portion devoid of reagent, wherein the liquid flows through the first bibulous matrix portion devoid of reagent to saturate the second reagent impregnated bibulous matrix portion in the analyte assay are with a constant volume of liquid per unit volume of the second regaent impregnated bibulous matrix portion.
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