초록 ▼

A polarographic sensor capable of monitoring lactic acid and lactate levels which can be incorporated on catheters to permit the in vivo study of lactate metabolism. A catheter may be directed to various parts of the vascular system by fluoroscopy so that the lactic acid and lactate concentrations a

A polarographic sensor capable of monitoring lactic acid and lactate levels which can be incorporated on catheters to permit the in vivo study of lactate metabolism. A catheter may be directed to various parts of the vascular system by fluoroscopy so that the lactic acid and lactate concentrations at a specific site may be monitored. The present invention makes it possible to continuously monitor lactate metabolism for an extended period of time.

대표청구항 ▼

An apparatus for the in vivo or in vitro measurement of concentrations of lactate, lactic acid, and derivatives thereof in blood at a specific site in a mammal body, wherein said lactate, lactic acid, or derivative thereof is reacted with an oxidase enzyme to produce pyruvate and hydrogen peroxide a

An apparatus for the in vivo or in vitro measurement of concentrations of lactate, lactic acid, and derivatives thereof in blood at a specific site in a mammal body, wherein said lactate, lactic acid, or derivative thereof is reacted with an oxidase enzyme to produce pyruvate and hydrogen peroxide and said hydrogen peroxide is measured polarographically, comprising: (a) a catheter; (b) an uncoated cathode positioned on and forming a tip of said catheter; (c) an anode positioned behind said cathode in spaced relation to said tip and surrounding said catheter wherein said anode and said cathode are electrically insulated from each other; (d) a multi-layered membrane completely surrounding said anode; (e) a potential source providing an electrical connection between said anode and said cathode; and (f) an oxidase meter connected to said potential source and adapted to detect a current produced between said anode and said cathode when said hydrogen peroxide diffuses through said membrane to contact said anode.