초록 ▼

An apparatus and method is described for applying epidermal growth factor (EGF) for achieving healing enhancement at a wound site. The human source of epidermal growth factor, designated as hEGF, is applied from the synthetic resin matrix system of this invention, and which comprises a polymer, such

An apparatus and method is described for applying epidermal growth factor (EGF) for achieving healing enhancement at a wound site. The human source of epidermal growth factor, designated as hEGF, is applied from the synthetic resin matrix system of this invention, and which comprises a polymer, such as poly(2-hydroxyl ethyl methyl methacrylate), referred to as PHEMA, an organic solvent, such as polyethylene glycol (PEG), and a hydrogen binding plasticizer, such as dimethylsulfoxide (DMSO). The plasticizer regulates the set-up time of the synthetic resin, so that the more plasticizer present, the shorter the set-up time. The dressing, once formed, and having the healing enhancer contained therein, may be sealed within various backing sheets, in order to preserve its aseptic condition. When ready for use, one of the backing sheets may be peeled away to expose the resin pad with the emobodied healing enhancer, ready for application to the wound site.

대표청구항 ▼

A synthetic resin matrix system for drug storage and extended duration drug release comprising a particulate, hydrophilic, water swellable polymer, and inert, non-toxic water miscible organic solvent, and a hydrogen bonding plasticizer; said polymer selected from the group consisting of a synthetic

A synthetic resin matrix system for drug storage and extended duration drug release comprising a particulate, hydrophilic, water swellable polymer, and inert, non-toxic water miscible organic solvent, and a hydrogen bonding plasticizer; said polymer selected from the group consisting of a synthetic resin matrix system for drug storage and extended duration drug release comprising a particulate, hydrophilic, water swellable polymer, an inert, non-toxic water miscible organic solvent, and a hydrogen bonding plasticizer, said polymer selected from the group consisting of hydroxy(C2-4alkyl) methacrylate, hydroxy(C2-4alkyl) acrylate, hydroxy(C2-4alkoxyC2-4alkyl) methacrylate, hydroxy(C2-4alkoxyC2-$alkyl) acrylate, alkoxy(C2-4alkoxyC2-4alkyl) methacrylate, alkoxy(C2-4alkoxyC2-4alkyl)acrylate, N-(C1-4alkyl) acrylamide, N-(C1-4alkyl) methacrylamide, N,N-di(C1-4alkyl) acrylamide, N,N-di(C1-4alkyl) methacrylamide, vicinal-epoxy(C1-4alkyl) methacrylate, or vicinal-epoxy(C1-4alkyl) acrylate, said solvent selected from the group consisting of polyethylene glycol or polypropylene glycol having a molecular weight averaging between about 200-2000 gram molecular weight units, and wherein said plasticizer being selected from the group consisting of dimethylsulfoxide, dimethylphthalate, 2,3-butylene carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethylsulfone, methylene glycolate, methylpropyl sulfone, or butyrolactone, with said polymer ranging between about 15%-50% by weight of said matrix system, with said solvent ranging between about 30%-65% by weight of said matrix system, with said plasticizer ranging up to about 20% by weight of said matrix system, and further including a medicament agent for local or systemic therapeutic effects, said medicament agent being a growth factor or healing enhancer.