초록 ▼

Implantable devices for medical use are provided which have been subjected to treatment with a crack preventative/antithrombogenic agent in the form of a sulfate. This treatment substantially prevents surface cracking or fissuring of the subcutaneous implantation as well as preventing thrombus forma

Implantable devices for medical use are provided which have been subjected to treatment with a crack preventative/antithrombogenic agent in the form of a sulfate. This treatment substantially prevents surface cracking or fissuring of the subcutaneous implantation as well as preventing thrombus formation along the blood contacting surfaces of the treated material.

대표청구항 ▼

A treatment method for substantially preventing in vivo cracking of biocompatible surfaces of implanted devices for medical use, consisting essentially of: providing a shaped substrate of an implantable medical device having a biocompatible polymeric surface that is susceptible to cracking when subj

A treatment method for substantially preventing in vivo cracking of biocompatible surfaces of implanted devices for medical use, consisting essentially of: providing a shaped substrate of an implantable medical device having a biocompatible polymeric surface that is susceptible to cracking when subjected to subcutaneous implantation under in vivo conditions for substantial time periods, such in vivo conditions including those that promote crack-forming biodegradation of said biocompatible polymeric surface; applying a crack preventive composition to said biocompatible polymeric surface, said crack preventive composition including a sulfonating agent, said sulfonating agent is selected from the group consisting of fuming sulfuric acid, concentrated sulfuric acid, sulfur trioxide vapors, and blends thereof with an alcohol or a blend of alcohols; reacting said sulfonating agent with said biocompatible polymeric surface in order to substantially prevent in vivo cracking of said surface without requiring any additional treatment of said surface; and said providing step includes selecting said substrate to contain a polymeric structure which contains aromatic moieties.