초록 ▼

A transdermal drug delivery system which is manufactured in a pre-activated state for at least one of storage stability, manufacture safety, user safety, or control of release characteristic considerations and which is activated by a patient (or other person applying the system to the patient) just

A transdermal drug delivery system which is manufactured in a pre-activated state for at least one of storage stability, manufacture safety, user safety, or control of release characteristic considerations and which is activated by a patient (or other person applying the system to the patient) just prior to or immediately after applying the system to the patient\s skin is disclosed.

대표청구항 ▼

A therapeutic substance non-releasing drug delivery system having a removable protective layer thereon, said system comprising (a) a therapeutic substance reservoir containing a therapeutic agent or precursor of said therapeutic agent in a first form which cannot permeate from said therapeutic reser

A therapeutic substance non-releasing drug delivery system having a removable protective layer thereon, said system comprising (a) a therapeutic substance reservoir containing a therapeutic agent or precursor of said therapeutic agent in a first form which cannot permeate from said therapeutic reservoir through said system to the surface of said system which is or was in contact with said removable protective layer; (b) an activating agent reservoir containing a system activating agent; (c) a burstable seal or membrane between (a) and (b) which is impermeable to said system activating agent and said therapeutic agent or precursor of said therapeutic agent; and (d) an occlusive backing layer; wherein upon bursting of said burstable seal or said burstable membrane, said system activating agent activates said system by contacting and converting said therapeutic agent or precursor of said therapeutic agent from said first form into a therapeutic agent second form which second form which migrates from said therapeutic agent or precursor of said therapeutic reservoir to said surface of said system which is or was in contact with said removable protective layer whereby said system becomes a therapeutic substance releasing delivery system.