초록 ▼

A medical device made from a material capable of being implanted in living tissue or transcutaneously inserted therein or of long term in-dwelling therein, which exhibits persistent antimicrobial activity in use, and containing a body of a synthetic or naturally occurring material having side surfac

A medical device made from a material capable of being implanted in living tissue or transcutaneously inserted therein or of long term in-dwelling therein, which exhibits persistent antimicrobial activity in use, and containing a body of a synthetic or naturally occurring material having side surfaces and being capable of being swelled by penetration of a swelling agent and which has been subjected to such a swelling agent which contains completely dissolved therein at least one antimicrobial agent as a solute, the surfaces being contacted by such swelling agent for a sufficient period of time to promote swelling of the matrix of a body of material and thereby permit diffusion and migration of the solution containing the selected antimicrobial agent solute into the interstitial spaces of the body of material at the molecular level by the action of the swelling agent within the body of material, and the solvent being capable of being removed from the solute in the body of material by evaporation and after removal of the solvent the body of material being capable of returning substantially to its original size and shape with the antimicrobial agent substantially uniformly deposited therein for subsequent continuous migration to and diffusion through the surfaces.

대표청구항 ▼

A medical device made from a material capable of being implanted in living tissue and of long indwelling therein, which exhibits persistent antimicrobial activity in use, and comprises: a body of a polymeric material which is capable of being swelled by a swelling agent and which has been subject to

A medical device made from a material capable of being implanted in living tissue and of long indwelling therein, which exhibits persistent antimicrobial activity in use, and comprises: a body of a polymeric material which is capable of being swelled by a swelling agent and which has been subject to such a swelling agent which contains completely dissolved therein one or more antimicrobial agents as a solute, said body being contacted by such swelling agent for a sufficient period of time to promote swelling of the body of material to enlarge the normal size and intermolecular spaces therewithin thereby causing diffusion and migration of the solution containing the selected antimicrobial agent(s) into the enlarged intermolecular spaces of the body of material by the action of the swelling agent within the body of material and said solvent being removed from said solute in the matrix of the body of material by evaporation with said solute remaining in the intermolecular spaces of the body of material and after removal of said solvent said body of material returning substantially to its original size and shape and having substantially normal intermolecular spaces with said antimicrobial agent substantially uniformly deposited therein for subsequent continuous molecular migration to and molecular diffusion through the surfaces to provide persistent antimicrobial activity at the surfaces of during use in the human body, said medical device subject to autoclaving prior to use; and said polymeric material and said antimicrobial agent(s) selected so that the rate of continuous molecular migration and molecular diffusion remains the same or is retarded by the effects of autoclaving.