[특허]Menthol enhancement of transdermal drug delivery

[미국특허] Menthol enhancement of transdermal drug delivery 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61L-015/03 A61F-013/00 A61K-031/56
출원번호	US-0031077 (1987-03-26)
발명자 / 주소	Tsuk Andrew G. (Plattsburgh NY)
출원인 / 주소	American Home Products Corp. (Del) (New York NY 02)
인용정보	피인용 횟수 : 12 인용 특허 : 29

초록

Disclosed herein are compositions and methods for enhancing the transdermal delivery of physiologically active agents across mammalian skin or membranes and which comprise a percutaneous transfer enhancing amount of menthol and a drug.

대표청구항 ▼

In the transdermal patch delivery art of applying to the skin of a mammal a unit transdermal dosage form, or patch, for transdermal delivery of physiologically active agents other than menthol to mammals comprising an effective amount of a systemically active water soluble or solubilizable drug other than menthol comprised within at least one drug reservoir the improvement which consists of including a percutaneous transfer enhancing amount of from about 4% to about 16% by weight of menthol comprised within a transdermal patch reservoir, matrix, or adhesive for attaching the transdermal patch dosage form to a mammal, wherein the drug other than menthol is selected from the group consisting of propranolol, conjugated estrogens, etodalac, 17-b

이 특허에 인용된 특허 (29) 인용/피인용 타임라인 분석

Kowcz Alexandra (Monroe CT) Doughty Darrell G. (Derby CT), Anti-acne composition.
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Matsui Ichiro (Toyama JPX) Tanaka Tsutomu (Kamiichi JPX) Bando Yukio (Toyama JPX) Ohashi Kiyonobu (Toyama JPX), Anti-inflammatory analgesic cataplasm and process for producing the same.
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Kigasawa Kazuo (Tokyo JPX) Ohtani Hideaki (Tokyo JPX) Kanezuka Toshiyuki (Kawasaki JPX), Antiinflammatory and analgesic gel.
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Parker Roger A. (Cincinnati OH), Antirhinovirus agents.
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Klein Robert W. (Blue Bell PA) Foxx Mary E. (Lansdale PA), Coal tar gel composition.
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Kamishita Takuzo (Takatsuki JPX) Kamishita Kazuhiko (Takatsuki JPX), Composition for topical application and method for preparing the same.
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Loveland Frederic D. (Suffern NY), Dermal and transdermal patches having a discontinuous pattern adhesive layer.
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Panoz Donald E. (Athlone IEX), Drug delivery device.
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Hymes Alan C. (Minnetonka MN) Ong Lincoln T. (Minnetonka MN) Persons Garry R. (Edina MN), Drug dispensing device for transdermal delivery of medicaments.
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Andriola Robert (Putnam Valley NY) Moore Donald J. (Pomona NY) Asche Henning (Bettingen CHX), Multicompartmentalized transdermal patches.
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Noda Kanji (Chikushino JPX) Nakagawa Akira (Tosu JPX) Yamagata Tetsuya (Tosu JPX) Kobayasi Masasi (Tosu JPX) Suenaga Tadayoshi (Mine JPX) Tokubuchi Fumiaki (Tosu JPX) Noguchi Kazuki (Ogohri JPX) Yosh, Novel plasters.
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Levy Michael A. (9911 Campbell Kansas City MO 64131), Penetrating topical medicament.
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Rajadhyaksha Vithal J. (Mission Viejo CA), Penetration enhancers for transdermal drug delivery of systemic agents.
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Bodor Nicholas (Gainesville FL) Loftsson Thorsteinn (Reykjavik ISX), Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol.
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Yamada Masayuki (Hyogo JPX) Uda Yoshiaki (Hyogo JPX), Percutaneous pharmaceuticals preparation for external use.
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Muller Bernd W. W. (Schlotfeldtsberg 14a 2302 Flintbek DEX) Franzky Hans-Jurgen (von-Coels-Str. 1 5100 Aachen DEX) Klln Claus-Jurgen (Eichofstr. 9 2300 Kiel DEX), Pharmaceutical multicomponent systems and method of preparing same.
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Inagi Toshio (Tokorozawa JPX) Inoue Masayuki (Higashi-Murayama JPX) Muramatsu Toyojiro (Sayama JPX), Pharmaceutical preparation for endermic application.
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Bordoloi Binoy K. (Covina CA) Ozari Yehuda (Arcadia CA) Dever Gerald R. (Mentor OH), Pressure-sensitive adhesive containing heat-sensitive materials, and method of making the same.
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Otsuka Saburo (Osaka JPX) Ito Yuusuke (Osaka JPX) Yoshikawa Toshiyuki (Osaka JPX) Tokuda Shoichi (Osaka JPX), Process for obtaining composite pharmaceutical preparation.
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Kigasawa Kazuo (Tokyo JPX) Ohtani Hideaki (Tokyo JPX) Tanaka Makoto (Tokyo JPX) Hayashida Shigeru (Tokyo JPX), Soft patch.
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Hidaka Osafumi (Tokyo JPX) Sakai Tomoki (Tokyo JPX) Sakano Toyoaki (Tokyo JPX), Sustained release pharmaceutical plaster.
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Higuchi, Takeru, Sympathomimetic topical and percutaneous administration with halogenated promoters.
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Luedders Wilmer L. (Cincinnati OH) Willins Richard E. (Cincinnati OH), Therapeutic composition.
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Haslam John L. (Lawrence KS) Higuchi Takeru (Lawrence KS) Mlodozeniec Arthur R. (Lawrence KS), Topical drug delivery system utilizing thermosetting gels.
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Grohe Klaus (Odenthal DEX), Topically applicable formulations of gyrase inhibitors in combination with corticosteroids.
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Schfer Rolf (Grabenmattstrasse 37 4133 Pratteln BL CHX) Schfer Werner (Auf der Wacht 33 4104 Oberwil BL CHX) Schfer Doris (Neue Blauenrainstrasse 9 4411 Arisdorf BL CHX), Transdermal carrier materials.
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Leonard Thomas W. (Plattsburgh NY) Enever Robin P. (Rouses Point NY) Mikula Karol K. (Morrisonville NY), Transdermal drug delivery system.
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Zupan Jacob A. (St. Joseph MO), Use of eucalyptol for enhancing skin permeation of bio-affecting agents.
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Rajadhyaksha Vithal Jagannath (Mission Viejo CA), Vehicle composition containing 1-substituted azacycloheptan-2-ones.
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이 특허를 인용한 특허 (12) 인용/피인용 타임라인 분석

Chen,Chih Ming; Cheng,Xiu Xiu, Controlled release oral dosage form of beta-adrenergic blocking agents.
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Koch, Andreas; von Falkenhausen, Christian; Matusch, Rudolf; Adam, Bernd, Device and method for increasing the transdermal permeation of medicaments.
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Sorge, Klaus; Loges, Hubert; Machinek, Arnold; Simchen, Ulrike; Surburg, Horst, Mixture containing menthol.
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Rodriguez,Gustavo C.; Whitaker,Regina Salas, Prevention of ovarian cancer by administration of a Vitamin D compound.
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Gustavo C. Rodriguez ; Regina Salas Whitaker, Prevention of ovarian cancer by administration of a vitamin D compound.
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Rodriguez, Gustavo C., Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium.
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Rodriguez, Gustavo C., Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium.
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Rodriguez Gustavo C., Prevention of ovarian cancer by administration of progestin products.
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Rodriguez, Gustavo C., Prevention of ovarian cancer by administration of progestin products.
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Yum, Su Il; Theeuwes, Felix, Transdermal delivery system for sufentanil.
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Yum, Su Il; Theeuwes, Felix, Transdermal delivery system for sufentanil.
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Yum, Su Il; Theeuwes, Felix, Transdermal delivery systems.
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[미국특허] Menthol enhancement of transdermal drug delivery 원문보기