초록 ▼

The residence time in the human stomach of pharmaceutical, gastric controlled release, solid units can be increased significantly if the units have a density that is much higher than normal. A preferred oral dosage form according to the invention comprises a capsule or other dosage form having a dim

The residence time in the human stomach of pharmaceutical, gastric controlled release, solid units can be increased significantly if the units have a density that is much higher than normal. A preferred oral dosage form according to the invention comprises a capsule or other dosage form having a dimension above 2 mm and that contains one or more of the said units. The density of each unit is preferably at least 2.5 and usually at least 2.7 g/ml and can conveniently be achieved by including at least 50% by weight of a weighting agent such as barium sulphate.

대표청구항 ▼

An oral, solid, pharmaceutical dosage form that is a capsule or disintegratable tablet and that has a minimum dimension of at least 2 mm and that is suitable for oral administration to humans and that comprises a plurality of controlled release units each comprising a pharmaceutically active ingredi

An oral, solid, pharmaceutical dosage form that is a capsule or disintegratable tablet and that has a minimum dimension of at least 2 mm and that is suitable for oral administration to humans and that comprises a plurality of controlled release units each comprising a pharmaceutically active ingredient and a pharmaceutically acceptable carrier that includes gastric controlled release binder that will permit controlled release of the active ingredient from the controlled release unit while in the stomach, and in which each said controlled release unit has a density of at least 2.5 g/ml.