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Electrolytic transdermal delivery of proteins

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61M-037/00
출원번호 US-0279315 (1988-12-01)
발명자 / 주소
  • Sibalis Dan (268 Hallock Rd. Stony Brook NY 11790) Rosen Sanford (64 E. 86th St. New York NY 10028)
인용정보 피인용 횟수 : 48  인용 특허 : 13

초록

A chemical composition for electrolytic transdermal transport of a protein to the blood stream of the patient comprises: (a) a protein, (b) a cosolvent with negative Setschenow constants, and (c) water. Some of the preferred proteins are: insulin, protamine sulfate, calcitonin, glucagon, and cortico

대표청구항

A transdermal patch for delivering at least one protein drug to the bloodstream of the patient comprising: a. at least one protein drug comprising at least one nonionic protein having more than 20 peptide units, water, and a water-destructuring agent with a negative Setschenow constant, contained in

이 특허에 인용된 특허 (13)

  1. Sibalis, Dan, Applicator for the non-invasive transcutaneous delivery of medicament.
  2. Kwiatek Alfred (New York NY) Schwartz Jack W. (Burlington VT), Device for the administration of an active agent to the skin or mucosa.
  3. Sibalis Dan (Stony Brook NY) Rosen Sanford (New York NY), Electrolytic transdermal delivery of polypeptides.
  4. Heller Jorge (Woodside CA) Skinner Wilfred A. (Portola Valey CA) Saito Kenichiro (Menlo Park CA) Satoh Susumu (Osaka JPX), Method for percutaneously administering physiologically active agents.
  5. Andriola Robert (Putnam Valley NY) Moore Donald J. (Pomona NY) Asche Henning (Bettingen CHX), Multicompartmentalized transdermal patches.
  6. Hung Chung-Ho (Milford MA) Thorn Richard (Milford MA) Riggin Charles (Hopdale MA) Marciani Dante (Hopkinton MA), Process for purifying recombinant proteins, and products thereof.
  7. Grimes Denise L. (Indianapolis IN) Hollinden C. Stephen (Indianapolis IN), Process for recovering insulin.
  8. Kanbayashi Yoshinori (Ohtsu JPX) Ui Michio (Sapporo JPX) Hosoda Koichi (Shiga JPX) Ito Akira (Ohtsu JPX) Kurokawa Shigeki (Ohtsu JPX) Terashima Akio (Shiga JPX) Takahashi Isamu (Ohtsu JPX) Yajima Mot, Proteinic active substances.
  9. Svenson Stefan (Brttnevgen 12 S-122 43 Enskede SEX), Purifying protein or peptide recombinant DNA products by electroseparation.
  10. Ash Stephen R. (Lafayette IN) Loeb Marvin P. (Chicago IL), System for demand-based adminstration of insulin.
  11. Litman David J. (Cupertino CA) Ullman Edwin F. (Atherton CA), Test strip kits in immunoassays and compositions therein.
  12. Hansen Bruno A. (Rodovre DKX) Andresen Finn H. (Hillerod DKX), Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect.
  13. Sibalis Dan (Stony Brook NY), Transdermal drug applicator and electrodes therefor.

이 특허를 인용한 특허 (48)

  1. Yanaki, Jamal S., Active electrode for transdermal medicament administration.
  2. Yanaki, Jamal S., Active transdermal medicament patch and circuit board for same.
  3. Thomas O. Murdock, Anhydrous drug reservoir for electrolytic transdermal delivery device.
  4. Andrew Blitzer ; Terry Pretorius, Athletic patch.
  5. Blitzer, Andrew; Pretorius, Terry, Athletic patch.
  6. Fossel, Eric T., Beneficial effects of increasing local blood flow.
  7. Wise, Lyn Marie; Fleming, Stephen Bruce; Mercer, Andrew Allan, Combination treatments and compositions for wound healing comprising viral VEGF.
  8. Gyory J. Richard ; Campbell Patricia S., Composition and method of enhancing electrotransport agent delivery.
  9. Bermudes, David Gordon, Compositions and methods for determining successful immunization by one or more vaccines.
  10. Fossel, Eric T., Delivery of ibuprofen and other compounds.
  11. Fossel, Eric T., Delivery of ibuprofen and other compounds.
  12. Fossel, Eric T., Delivery of ibuprofen and other compounds.
  13. Epshtein, Haim; Vaynberg, Boris, Device, apparatus, and method of adipose tissue treatment.
  14. Epshtein, Haim; Vaynberg, Boris, Device, apparatus, and method of adipose tissue treatment.
  15. Flyash, Lion; Vaynberg, Boris, Disposable electromagnetic energy applicator.
  16. Sibalis Dan (Stony Brook NY), Electrolytic transdermal delivery of polypeptides.
  17. Hoff, Andrew M.; Gilbert, Richard; Heller, Richard; Jaroszeski, Mark J., Electromanipulation device and method.
  18. Eckhouse, Shimon; Kutscher, Tuvia Dror, Hair removal apparatus for personal use and the method of using same.
  19. Akiyama, Hidero; Nakayama, Mizuo; Matsumura, Takehiko; Matsumura, Akihiko, Iontophoresis device.
  20. Kanamura, Kiyoshi; Kosiba, Nobuharu; Nakayama, Mizuo; Matsumura, Takehiko; Akiyama, Hidero; Matsumura, Akihiko, Iontophoresis device.
  21. Kanamura, Kiyoshi; Matsumura, Takehiko; Nakayama, Mizuo; Akiyama, Hidero; Matsumura, Akihiko, Iontophoresis device.
  22. Tanioka, Akihiko; Minagawa, Mie; Kanamura, Kiyoshi; Matsumura, Akihiko; Nakayama, Mizuo; Matsumura, Takehiko; Akiyama, Hidero, Iontophoresis device.
  23. Haak, Ronald P.; Gyory, J. Richard; Theeuwes, Felix; Landrau, Felix A.; Roth, Nathan; Myers, Robert M., Iontophoretic delivery device and method of hydrating same.
  24. Carter, Darrick, Iontophoretic device and method of delivery of active agents to biological interface.
  25. Carter, Darrick; Smith, Gregory A., Iontophoretic systems, devices, and methods of delivery of active agents to biological interface.
  26. Smith, Kendall A., Low dose IL-2 for potentiation of immunity.
  27. Bar-El, Yossi; Arbel, Giora, Magnetic patch coupling.
  28. Hyatt Gary F. ; Bostic William M., Medical applicator and method.
  29. Eckhouse, Shimon; Kutscher, Tuvia Dror; Vaynberg, Boris, Method and apparatus for personal skin treatment.
  30. Eckhouse, Shimon; Kutscher, Tuvia Dror; Vaynberg, Boris, Method and apparatus for personal skin treatment.
  31. Smith Kendall A., Method of stimulation of immune response with low doses of IL-2.
  32. Kraft, Edward R.; Kulp, Gabriela, Photokinetic delivery of biologically active substances using pulsed incoherent light.
  33. Kraft,Edward R.; Kulp,Gabriela, Photokinetic delivery of biologically active substances using pulsed incoherent light.
  34. Smith, Kendall A., Stimulation of immune response with low doses of cytokines.
  35. Fossel, Eric T., Systems and methods for treatment of allergies and other indications.
  36. Carter, Darrick; Hoyt, Joshua K.; Thorne, James; Seitz, Forrest, Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices.
  37. Venkatraman Subramanian S. ; Goldman Eli J. ; Kleiner Lothar W. ; Pudjijanto Stephanus, Thin polymer film drug reservoirs.
  38. Luo, Eric C.; Hsu, Tsung-Min, Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers.
  39. Luo, Eric C.; Jacobson, Eric C.; Hsu, Tsung-Min, Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers.
  40. Fossel, Eric T., Topical composition containing naproxen.
  41. Fossel, Eric Thor, Transdermal delivery of beneficial substances effected by a hostile biophysical environment.
  42. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  43. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  44. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  45. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  46. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  47. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  48. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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