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특허 상세정보

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Process for oligonucleo tide synthesis using phosphormidite intermediates

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) C07H-021/02    C07H-021/04   
미국특허분류(USC) 536/27 ; 536/28 ; 536/29
출원번호 US-0909070 (1986-09-18)
발명자 / 주소
출원인 / 주소
인용정보 피인용 횟수 : 287  인용 특허 : 4
초록

A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.

대표
청구항
▼

In a process for producing oligonucleotides which comprises the step of condensing the 3′-OH or 5′-OH group of a nucleoside or oligonucleotide with a nucleoside phosphite, the improvement being that the nucleoside phosphite is a compound of one of the formulae: [Figure] wherein B is a nucleoside or deoxynucleoside base; A is H OH or OR4 in which R4 is a blocking group; R is a blocking group; R1′is a hydrocarbyl radical containing up to about carbon atoms; and X is NR2′R3′, wherein R2′and R3′taken separately each represent alkyl, aryl, aralkyl, cycloalkyl...

이 특허에 인용된 특허 (4)

  1. Caruthers Marvin H. (Boulder CO) Matteucci Mark D. (San Francisco CA). Nucleosides useful in the preparation of polynucleotides. USP1985024500707.
  2. Caruthers Marvin H. (Boulder CO) Beaucage Serge L. (Boulder CO). Phosphoramidite compounds and processes. USP1983114415732.
  3. Caruthers Marvin H. (Boulder CO) Matteucci Mark D. (Boulder CO). Process for preparing polynucleotides. USP1984074458066.
  4. Kster Hubert (Hamburg DEX) Sinha Nanda D. (Bundu Dt. Ranchi INX). Process for the preparation of oligonucleotides. USP1988024725677.

이 특허를 인용한 특허 피인용횟수: 287

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