초록 ▼

Disclosed is a matrix material for implantation in a mammalian host comprising biocompatible mineral-free type I bone collagen, xenogenic to the host, and biodegradable therewithin. The matrix is manufactured from protein-extracted bone powder treated with certain swelling agents to increase its sur

Disclosed is a matrix material for implantation in a mammalian host comprising biocompatible mineral-free type I bone collagen, xenogenic to the host, and biodegradable therewithin. The matrix is manufactured from protein-extracted bone powder treated with certain swelling agents to increase its surface area and porosity. The matrix may be combined with osteogenic protein to induce reliably and reproducibly endochondral bone formation. It also can be used as a surface coat around implantable prosthetic devices to promote cellular ingrowth or as a carrier for sustained release of various therapeutic compositions.

대표청구항 ▼

A method of manufacturing a biocompatible, in vivo biodegradable matrix suitable for implantation in a mammalian host, said method comprising the steps of: A. providing insoluble, demineralized, quanidine-extracted, nonadherent bone particles, xenogenic to said host, having a mean particle diameter

A method of manufacturing a biocompatible, in vivo biodegradable matrix suitable for implantation in a mammalian host, said method comprising the steps of: A. providing insoluble, demineralized, quanidine-extracted, nonadherent bone particles, xenogenic to said host, having a mean particle diameter within the range of 70 mm to 850 mm; B. contacting the insoluble particles with a swelling agent to increase the intraparticle surface area and intraparticle porosity of said insoluble particles while maintaining the particles intact; C. washing the insoluble particles which result from step B to remove dissociated non-collagenous components thereof; and D. close-packing the resulting porous particles to form said matrix.