초록 ▼

Diacetylinic phosophocholines have distinctly different endothermic and exothermic transition temperatures. Lipid tubules are formed by hydrating a diacetylinic phosphocholine at a temperature above its endothermic transition temperature. The hydrated lipid is then cooled slowly to a formation tempe

Diacetylinic phosophocholines have distinctly different endothermic and exothermic transition temperatures. Lipid tubules are formed by hydrating a diacetylinic phosphocholine at a temperature above its endothermic transition temperature. The hydrated lipid is then cooled slowly to a formation temperature 1°to 10°C. below the exothermic transition temperature to form tubule structures. The tubules structures can be polymerized to form permanent tubules. The tubules can be used in the same manner as a liposome vesicle or they can be metal coated for a variety of applications.

대표청구항 ▼

A method of forming tubules relatively free from amorphous material from diacetylinic phosphocholines having hydrocarbon chains of 15 to 29 carbons each comprising the steps of: hydrating a diacetylinic phosphocholine crystalline, lipid powder above its endothermic transition temperature; cooling sa

A method of forming tubules relatively free from amorphous material from diacetylinic phosphocholines having hydrocarbon chains of 15 to 29 carbons each comprising the steps of: hydrating a diacetylinic phosphocholine crystalline, lipid powder above its endothermic transition temperature; cooling said hydrated lipid at a rate not exceeding 1°per minute to a formation temperature 1°to 10°C. below the exothermic transition temperature; and holding said formation temperature for 30 minutes to 2 hours to form tubule structures. The method of claim 4 wherein the tubule structure is polymerized to a permanent form.