초록 ▼

The multilayer test devices of this invention comprise, in order, (a) an absorbent layer; (b) a waterproof barrier layer; and (c) a quickly absorbent reagent layer having a determinate volume. The absorbent and barrier layers each include an aperture functionally aligned for application of a test sa

The multilayer test devices of this invention comprise, in order, (a) an absorbent layer; (b) a waterproof barrier layer; and (c) a quickly absorbent reagent layer having a determinate volume. The absorbent and barrier layers each include an aperture functionally aligned for application of a test sample through the absorbent and barrier layers and onto the surface of the reagent layer. The reagent layer contains one or more reagents which produce a detectable species in the presence of an analyte. The reagent layer preferably comprises an asymmetrical filter, which localizes cellular components of the test sample at or near the surface of the filter, while facilitating saturation of the filter by non-cellular sample components. Preferred embodiments of the test devices include devices for testing glucose, alcohol, cholesterol, or other analytes in whole blood.

대표청구항 ▼

A multilayer testing device comprising, in sequential contact, (a) an absorbent layer; (b) a waterproof barrier layer; and (c) a quickly absorbent reagent matrix layer having a determinate volume, and containing therein at least one reagent which produces a detectable species in the presence of an a

A multilayer testing device comprising, in sequential contact, (a) an absorbent layer; (b) a waterproof barrier layer; and (c) a quickly absorbent reagent matrix layer having a determinate volume, and containing therein at least one reagent which produces a detectable species in the presence of an analyte; wherein the absorbent and barrier layers each include an aperture functionally aligned for application of a test sample through the absorbent and barrier layers and onto a surface of the reagent layer and the reagent layer comprises an asymmetrically porous membrane having progressively finer filtration with increased distance from the barrier layer.