New aminochromanol compounds of the formula: [Figure] (I) [Figure] in which X is cyano, nitro, trifluoromethyl, alkoxycarbonyl, carbamido, dialkylcarbamido, aminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl, alkylsulfonylamino or acyl; CH2-R is attached (in the 5 position of the pyrrolidinone nucle
New aminochromanol compounds of the formula: [Figure] (I) [Figure] in which X is cyano, nitro, trifluoromethyl, alkoxycarbonyl, carbamido, dialkylcarbamido, aminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl, alkylsulfonylamino or acyl; CH2-R is attached (in the 5 position of the pyrrolidinone nucleus) to an R- or S-configured carbon atom, and R is: either OR′or SR′in which R′is hydrogen, (C1-C10)-alkyl, (C1-C5-alkyl)-carbonyl or [Figure] and physiologically tolerable acid addition salts thereof, in the case where R contains a basic function. These compounds and their physiologically tolerable salts can be used in therapeutics for the activation of potassium channels, especially in the treatment of disorders associated with abnormal smooth muscle contraction and in the cardiovascular, bronchopulmonary, digestive, urinary and uterine fields.
대표청구항▼
A compound selected from the group consisting of: amino chromanol compounds of formula I: [Figure] (I) [Figure] in which: X is selected from the group consisting of: cyano, nitro, trifluoromethyl, alkoxycarbonyl in which the alkoxy group contains 1 to 5 carbon atoms, carbamido, dialkylcarbamido, ami
A compound selected from the group consisting of: amino chromanol compounds of formula I: [Figure] (I) [Figure] in which: X is selected from the group consisting of: cyano, nitro, trifluoromethyl, alkoxycarbonyl in which the alkoxy group contains 1 to 5 carbon atoms, carbamido, dialkylcarbamido, aminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl and alkylsulfonylamino in which the alkyl groups each contain 1 to 5 carbon atoms, and acyl selected from: acetyl, propionyl, benzoyl and trifluoroacetyl; CH2-R is attached (in the 5 position of the pyrrolidinone nucleus) to an R- or S- configured carbon atom, and R is selected from the group consisting of: (a) -OR′and -SR′radicals in which R′is selected from the group consisting of: hydrogen; alkyl and hydroxyalkyl having up to 10 carbon atoms, and such radical interrupted by an oxygen atom; alkylcarbonyl in which alkyl contains up to 5 carbon atoms; [Figure] in which: n is an integer from 2 to 5, and R1 and R2, which are identical or different, are each selected from the group consisting of: hydrogen, alkyl having 1 to 5 carbon atoms, and (b) [Figure] in which R1 and R2 have the meanings given above, and physiologically-tolerable acid addition salts of the compounds of the formula I wherein R contains a basic function.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (3)
Cassidy Frederick (Harlow GB2), Antihypertensive chromans and chromenes.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.