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Immunostimulatory microsphere 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/16
출원번호 US-0270276 (1988-11-14)
발명자 / 주소
  • Cahn Frederick (57 Raleigh Rd. Belmont MA 02178)
인용정보 피인용 횟수 : 109  인용 특허 : 4

초록

The invention relates to the use of an improved carrier or adjuvant to induce a therapeutic response to a weak antigen.

대표청구항 ▼

A macroporous microsphere comprising a particle and an antigenic component, selected from the group consisting of whole inactivated pathogens and submits thereof, RDNA derived polyreptides, recombinant viruses, synthesized polypeptides and anti-idiotypes, and whole microorganisms or animal cells whe

이 특허에 인용된 특허 (4)

  1. Kreuter Jorg (25 Mnstergasse CH-8001 Zurich CHX) Speiser Peter P. (26 Wassbergstrasse CH-8127 Forch CHX), Biological materials.
    상세보기
  2. Yannas Ioannis V. (Newton Center MA) Burke John F. (Belmont MA) Orgill Dennis P. (Cambridge MA) Skrabut Eugene M. (Beverly MA), Method of promoting the regeneration of tissue at a wound.
    상세보기
  3. Yannas Ioannis V. (Newton Center MA) Burke John F. (Belmont MA), Method of using a fibrous lattice.
    상세보기
  4. Yannas Ioannis V. (Newton Center MA) Forbes Martin J. (Kirkland CAX), Procedures for preparing composite materials from collagen and glycosaminoglycan.
    상세보기

이 특허를 인용한 특허 (109)

  1. Vournakis, John N.; Finkielsztein, Sergio, Anti-bacterial applications of poly-N-acetylglucosamine nanofibers.
    상세보기
  2. Vournakis, John N.; Finkielsztein, Sergio, Anti-bacterial applications of poly-N-acetylglucosamine nanofibers.
    상세보기
  3. Vournakis, John N.; Finkielsztein, Sergio, Anti-bacterial applications of poly-N-acetylglucosamine nanofibers.
    상세보기
  4. Vournakis, John N.; Finkielsztein, Sergio, Anti-bacterial applications of poly-N-acetylglucosamine nanofibers.
    상세보기
  5. Gengoux-Sedlik Christine,FRX ; LeClerc Claude,FRX, Antigen-carrying microparticles and their use in the indication of humoral or cellular responses.
    상세보기
  6. Warren, William L.; Fahlenkamp, Heather; Higbee, Russell; Kachurin, Anatoly; Li, Conan; Nguyen, Mike; Parkhill, Robert; Sanchez-Schmitz, Guzman; Irvine, Darrell J.; Randolph, Gwendalyn J.; Hacohen, Nir; Torbett, Bruce, Artificial immune system: methods for making and use.
    상세보기
  7. Warren, William L; Fahlenkamp, Heather; Higbee, Russell; Kachurin, Anatoly; Li, Conan; Nguyen, Mike; Parkhill, Robert; Sanchez-Schmitz, Guzman; Irvine, Darrell J.; Randolph, Gwendalyn J.; Harcohen, Nir; Torbett, Bruce, Artificial immune system: methods for making and use.
    상세보기
  8. Warren, William L; Fahlenkamp, Heather; Higbee, Russell; Kachurin, Anatoly; Li, Conan; Nguyen, Mike; Parkhill, Robert; Sanchez-Schmitz, Guzman; Irvine, Darrell J.; Randolph, Gwendalyn J.; Hacohen, Nir; Torbett, Bruce, Artificial immune system: methods of use.
    상세보기
  9. Warren, William L; Fahlenkamp, Heather; Higbee, Russell; Kachurin, Anatoly; Li, Conan; Nguyen, Mike; Parkhill, Robert; Sanchez-Schmitz, Guzman; Irvine, Darrell J.; Randolph, Gwendalyn J.; Harcohen, Nir; Torbett, Bruce, Artificial immune system: methods of use.
    상세보기
  10. Sanchez-Schmitz, Guzman; Higbee, Russell; Fahlenkamp, Heather; Irvine, Darrell J.; Warren, William L.; Drake, III, Donald, Artificial lymphoid tissue equivalent.
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  11. Mahmood, Ayesha; Kachurin, Anatoly; Warren, William; Higbee, Russell, Artificial tissue constructs comprising alveolar cells and methods for using the same.
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  12. Mahmood, Ayesha; Kachurin, Anatoly; Warren, William; Higbee, Russell, Artificial tissue constructs comprising alveolar cells and methods for using the same.
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  13. Warren, William L.; Parkhill, Robert; Nguyen, Michael N.; Sanchez-Schmitz, Guzman; Fahlenkamp, Heather; Higbee, Russell; Drake, III, Donald; Kachurin, Anatoly; Moe, David, Automatable artificial immune system (AIS).
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  14. Vournakis, John N.; Finkielsztein, Sergio; Pariser, Ernest R.; Helton, Mike, Bicompatible poly-β-1→4-N-acetylglucosamine.
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  15. Vournakis, John N.; Finkielsztein, Sergio; Pariser, Ernest R.; Helton, Mike, Biocompatible poly-β-1→4-N-acetylglucosamine.
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  16. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
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  17. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
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  18. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
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  19. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
    상세보기
  20. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
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  21. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
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  22. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
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  23. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
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  24. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
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  25. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
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  26. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
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  27. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
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  28. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
    상세보기
  29. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
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  30. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
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  31. Rock Kenneth L., Compositions and methods for inducing cytotoxic T lymphocyte responses by immunization with protein antigens.
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  32. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
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  33. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
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  34. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
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  35. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
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  36. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
    상세보기
  37. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
    상세보기
  38. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
    상세보기
  39. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
    상세보기
  40. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
    상세보기
  41. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
    상세보기
  42. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
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  43. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
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  44. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
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  45. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
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  46. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
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  48. Pardoll Drew ; Azhari Rosa,ILX ; Leong Kam W. ; Golumbek Paul ; Jaffee Elizabeth ; Levitsky Hyam ; Lazenby Audrey, Controlled release of pharmaceutically active substances for immunotherapy.
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  51. Warren, William L.; Higbee, Russell; Mishkin, Eric; Sanchez-Schmitz, Guzman; Fahlenkamp, Heather; Rivard, Michael, Disease model incorporation into an artificial immune system (AIS).
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  • Le Buannec, Helene; Zagury, Daniel, Stable immunogenic product comprising antigenic heterocomplexes.
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  • Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Systems, devices, and methods for making or administering frozen particles.
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  • Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Systems, devices, and methods for making or administering frozen particles.
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  • Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Systems, devices, and methods for making or administering frozen particles.
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  • Vu L. Truong ; Thomas August ; Kam W. Leong, Targeted gene delivery system.
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