초록

Pharmaceutically active substances are administered in aerosol form by applying to a mucosal surface of the body a composition comprising a medically effective amount of a pharmaceutically active substance, a biocompatible amphiphilac steroid and a bicompatible (hydro/fluoro)carbon propellant.

대표청구항 ▼

A nonaqueous, dry powder composition for the transmucosal administration of pharmaceutically active substance, comprising a particulate suspension of: (a) a medically effective amount of a polypeptide drug and (b) a biocompatible steroid of the formula [Figure] wherein a dashed line represents a sin

A nonaqueous, dry powder composition for the transmucosal administration of pharmaceutically active substance, comprising a particulate suspension of: (a) a medically effective amount of a polypeptide drug and (b) a biocompatible steroid of the formula [Figure] wherein a dashed line represents a single or double bond; D represents a group having a molecular weight below 600 daltons which renders an effective amount of said steroid water soluble within the range of about pH 2 to about pH 12; E represents OAc, OH, a lower alkyl group or a lower heteroalkyl group; G represents OAc, OH, a lower alkyl group or a lower heteroalkyl group; W represents OAc or H; and Q, V, and X, each individually, represent OH or H, said steroid (i) containing two to three polar functions, exclusive of the function represented by D; and (ii) being capable of increasing the permeation of a human or animal mucosal surface by a pharmaceutically active substance, in an amount effective to increase the permeability of said body surface to a pharmaceutically active substance; and wherein said particulate suspension is suspended in a biocompatible (hydro/fluoro) carbon propellant.