Molock Frank (Lawrenceville GA) Su Kai C. (Alpharetta GA)
출원인 / 주소
Ciba-Geigy Coproation (Ardsley NY 02)
인용정보
피인용 횟수 :
19인용 특허 :
5
초록▼
Contact lenses which are optically clear, wettable, flexible, of high oxygen permeability and substantially non-swellable in the aqueous ocular environment of use, of a polymer containing polyoxyalkylene backbone units are disclosed, as well as the preparation thereof and methods of treating vision
Contact lenses which are optically clear, wettable, flexible, of high oxygen permeability and substantially non-swellable in the aqueous ocular environment of use, of a polymer containing polyoxyalkylene backbone units are disclosed, as well as the preparation thereof and methods of treating vision defects therewith.
대표청구항▼
An optically clear, wettable, flexible, hydrolytically stable, biologically inert, substantially siloxane free, and oxygen permeable crosslinked polymer comprising a) units of formula I [Figure] (I) wherein each b, d, and f is independently 0-4; each q is a number of 1-1000; each x, y, and z is ind
An optically clear, wettable, flexible, hydrolytically stable, biologically inert, substantially siloxane free, and oxygen permeable crosslinked polymer comprising a) units of formula I [Figure] (I) wherein each b, d, and f is independently 0-4; each q is a number of 1-1000; each x, y, and z is independently a number from 0 to a number such that (x+y+z) times q within each unit of formula I is 4-1000; each R1-R18 is selected from the group consisting of (i) hydrogen, and (ii) aromatic or alicyclic containing radical, each of which uninterrupted or interrupted by a heteroatom provided no carbon atom in said unit is geminally singly-bound to oxygen atoms; or any 2 adjacent groups R1-R18, together with the atoms to which they are attached can form a 5-8 membered ring; or R1-R18 may independently be additionally selected from, or any of the aforementioned R1-R18 groups may have a substituent which is a cross-linkable moiety provided that no carbon atoms bearing geminally singly-bound oxygen atoms results; the terminal oxygen atom within any unit of formula I being replaceable by [Figure] wherein R19 is hydrogen, C1-4 alkyl or phenyl; with the proviso that when b, d, and f are all zero, at least one of R1, R2, R5-R8, R11-R14, R17, and R18 in at least a portion of the units of formula I is other than hydrogen; and further provided that R1-R18 individually, or in the aggregate, is sufficiently hydrophobic such that in the absence of a hydrophilic modifier unit, the resulting polymer is substantially non-swellable in water; and b) a hydrophilic modifier unit in an amount sufficient to maintain the water content of said crosslinked polymer in excess of 10%; said cross-linked polymer having a receding contact angle with distilled water of less than 60°when measured at 20°C. and an oxygen permeability Dk greater than about 1-1.5 times that of polyhydroxyethyl methacrylate said hydrophilic modifier unit being the residue of a reactive monomer selected from N,N-dimethylacrylamide, or a) polyethylene glycols of the formula [Figure] (A) or b) pyrrolidones of the formula [Figure] (B) wherein R20 is H or lower alkyl, n is 1-25, and R21 is an ethylenically unsaturated group or c) of the formula (R21-d21 is a polymerizable moiety selected from the group consisting of ethylenically unsaturated radicals, epoxy groups, anhydrides, isocyanates, amines, acids, esters amides, ethers, acid halides, and hydroxy; 8 is selected from i) a divalent aliphatic group of up to 25 carbon atoms which may also be interrupted or terminated, or interrupted and terminated by oxy, carbonyloxy, amino, aminocarbonyl, oxycarbonyl, ureido, oxycarbonylamino, or carbonyl amino; ii) a divalent 5-7 membered cycloaliphatic and a 5-7 membered cycloaliphatic-C1-20aliphatic which may also be interrupted, terminated, or interrupted and terminated as in group i) above except that said interruptions cannot occur within the cycloaliphatic portions; iii) a divalent arylene having 6-25 carbon atoms which also is unsubstituted or substituted by at least one substituent selected from halogen, C1-4 alkyl, and C1-12 perhalo alkyl; iv) a divalent aralkyl or alkaryl having 7-25 carbon atoms which is uninterrupted or interrupted in the alkyl portion, or terminated, or interrupted in the alkyl portion and terminated with an interrupting or terminating group as mentioned in i) above, and each of said uninterrupted, interrupted, and terminated aralkyl and alkaryl groups is further unsubstituted or further substituted by a substituent selected from halogen, C1-4 alkyl, and C1-12 perhaloalkyl; and [Figure] (D) wherein na=8-100, each Ra is CH3 and each Rb is H and nb is 0 or each Ra is H and each Rb is CH3 and nb is zero or Ra and Rb are each H and nb is 1; and H′is a hydrophilic group selected from a) morpholino, cyclic amide radicals of 5-7 ring members; saturated and unsaturated cyclic N,N-diamides of 5-6 ring members, [Figure] wherein nc and nd are each selected from 0-2; cyclic amines of 5-6 members; each unsubstituted or substituted by hydroxy-C1-5 alkyl, carboxy, or lower alkyl b) tetrahydrofurfuryl c) mono, di, and poly saccharide radicals, whether straight chain or cyclic, and the corresponding sugar alcohol radicals, pentaerythritol radicals, polyvinyl alcohol radicals, and d) (poly hydroxy C2-C7alkyl) radicals and Z′is 1 up to the valency of said H′and when Z′is less than the valency of H′, such excess valences are taken up by hydrogen; wherein the reactive group R21 is capable of reacting with one or more non hydrophilic modifier sites in said polymer.
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이 특허에 인용된 특허 (5)
Molock Frank (Lawrenceville GA) Robertson ; Jr. J. Richard (Alpharetta GA) Su Kai C. (Alpharetta GA), Hydrophilic modifier monomers.
Su Kai C. (Alpharetta GA) Molock Frank F. (Lawrenceville GA), Wettable, flexible, oxygen permeable, substantially non-swellable contact lens containing polyoxyalkylene backbone units.
Su Kai C. (Alpharetta GA) Molock Frank F. (Lawrenceville GA), Wettable, flexible, oxygen permeable, substantially non-swellable contact lens containing polyoxyalkylene backbone units.
Chabrecek Peter (Basel CHX) Lohmann Dieter (Munchenstein CHX), Functionalized photoinitiators, macromers thereof, and the use thereof for contact lens.
Hill Gregory A. (Ponte Vedra Beach FL) Frisch Kurt C. (Grosse Ile MI) Sendijarevic Vahid (Troy MI) Wong Shaio-Wen (St. Clair Shores MI), Interpenetrating polymer networks for contact lens production.
Molock Frank F. (Orange Park FL) Nunez Ivan M. (Jacksonville FL) Ford James D. (Orange Park FL) Elliott Laura D. (Jacksonville FL), Polymeric ophthalmic lens with crosslinker containing saccharide residue.
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