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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0633289 (1990-12-24) |
우선권정보 | GB-0000863 (1989-01-16) |
발명자 / 주소 |
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출원인 / 주소 |
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인용정보 | 피인용 횟수 : 529 인용 특허 : 0 |
A compound selected from the group consisting of a compound of the formula [Figure] wherein R1 and R2 are individually selected from the group consisting of hydrogen, alkyl and hydroxyalkyl of 1 to 5 carbon atoms and amino, n is an integer from 1 to 3, X and X1 are individually selected from the gro
A compound selected from the group consisting of a compound of the formula [Figure] wherein R1 and R2 are individually selected from the group consisting of hydrogen, alkyl and hydroxyalkyl of 1 to 5 carbon atoms and amino, n is an integer from 1 to 3, X and X1 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms or taken together with the carbon atom to which they are attached are [Figure] Y is -O-or -S-, R3 is alkyl of 1 to 3 carbon atoms or aryl of 6 to 8 carbon atoms, [Figure] is selected from the group consisting of [Figure] R4 and R5 are individually aryl unsubstituted or substituted with at least one member of the group consisting of halogen, -NO2 and alkyl and alkoxy of 1 to 3 carbon atoms and non-toxic, pharmaceutically acceptable salts thereof with acids and bases having cyclooxygenase inhibiting and antibiotic acitvity.
A process for the preparation of a compound selected from the group consisting of a compound of the formula [Figure] I wherein R1 and R2 are individually selected from the group consisting of hydrogen, alkyl and hydroxyalkyl of 1 to 5 carbon atoms and amino, n is an integer from 1 to 3, X and X1 are
A process for the preparation of a compound selected from the group consisting of a compound of the formula [Figure] I wherein R1 and R2 are individually selected from the group consisting of hydrogen, alkyl and hydroxyalkyl of 1 to 5 carbon atoms and amino, n is an integer from 1 to 3, X and X1 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms or taken together with the carbon atom to which they are attached are [Figure] Y is -O-or -S-, R3 is alkyl of 1 to 3 carbon atoms or aryl of 6 to 8 carbon atoms, [Figure] is selected from the group consisting of [Figure] R4 and R5 are individually aryl unsubstituted or substituted with at least one member of the group consisting of halogen, -NO2 and alkyl and alkoxy of 1 to 3 carbon atoms and non-toxic, pharmaceutically acceptable salts thereof with acids and bases comprising effecting a cyclo addition reaction between a compound of the formula [Figure] II wherein [Figure] is as defined above and a compound of the formula [Figure] III wherein R1, R2, n, X, X1, Y and R3 are as defined above to obtain the compound of formula I.
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