Ottow Eckhard (Berlin DEX) Wiechert Rudolf (Berlin DEX) Neef Gunter (Berlin DEX) Beier Sybille (Berlin DEX) Elger Walter (Berlin DEX) Henderson David A. (Berlin DEX)
출원인 / 주소
Schering Aktiengesellschaft (Berlin and Bergkamen DEX 03)
인용정보
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초록▼
New 19,11b1 stands for a methyl or ethyl radical, R2 for a hydrogen or chlorine atom or a C1-C4-alkyl radical, B and G, which are the same or different, respectively for a hydrogen atom, a C1-C4-alkyl radical or, together, for a second bond between the carbon atoms 6 and 7, B and R2 together for a m
New 19,11b1 stands for a methyl or ethyl radical, R2 for a hydrogen or chlorine atom or a C1-C4-alkyl radical, B and G, which are the same or different, respectively for a hydrogen atom, a C1-C4-alkyl radical or, together, for a second bond between the carbon atoms 6 and 7, B and R2 together for a methylene or an ethylene group, Z for the radical of a pentagonal or hexagonal ring, which is possibly substituted and possibly unsaturated, V stands for a possibly substituted carbocyclic or heterocyclic aryl radical, the ring A for [Figure] a) M and N together meaning a second bond or M a hydrogen atom and N a hydroxy group, X means an oxygen atom, two hydrogen atoms or a hydroxyimino grouping N_OH, R3 and D, which are the same or different, respectively a hydrogen atom, a nitrile radical or a C1-C4-alkyl radical or, together, a methylene or ethylene group, E a hydrogen atom or a C1-C4-alkyl radical, D and E together meaning a second bond between carbon atoms 1 and 2 or together a methylene group [Figure] b) or [Figure] c) with R11 in the meaning of a hydrogen atom or a C1-C8-alkyl radical, are described as well as their pharmaceutically tolerated addition salts with acids. The new compounds possess valuable pharmacological properties.
대표청구항▼
A 19, 11b1 is a methyl or ethyl radical; R2 is hydrogen, chlorine or C1-C4-alkyl radical; B and G, being the same or different, are each hydroge or C1-C4-alkyl radical; B and G, together, can also be a second bond between carbon atoms 6 and 7; B and R2, together, can also be a methylene or ethylene
A 19, 11b1 is a methyl or ethyl radical; R2 is hydrogen, chlorine or C1-C4-alkyl radical; B and G, being the same or different, are each hydroge or C1-C4-alkyl radical; B and G, together, can also be a second bond between carbon atoms 6 and 7; B and R2, together, can also be a methylene or ethylene group; Z is a substituted or unsubstituted, saturated or unsaturated, 5- or 6-member ring; V is an unsubstituted or substituted, carbocyclic or heterocyclic, aryl radical; ring A is [Figure] a) wherein M and N, together, are a second bond, or M is hydrogen and N is hydroxy, in which case B, R2, G, R3, D and E are all each hydrogen. X is an oxygen atom, two hydrogen atoms or one hydroxyimino group (N_OH), R3 and D, being the same or different, are each hydrogen nitrile, or C1-C4-alkyl radical, R3 and D, together, can also be a methylene or ethylene group, E is hydrogen or C1-C4-alkyl radical, D and E, together, can also be a second bond between carbon atoms 1 and 2 or, together, can also be a methylene group; or Ring A is [Figure] (b) or Ring A is [Figure] (c) wherein R11 is hydrogen or C1-C8-alkyl radical; and pharmaceutically tolerated acid addition salts thereof.
Weiss Wilfried (Oberursel DEX) Rittmeyer Peter (Sulzbach DEX) Emmel Ute (Frankfurt am Main DEX), Dissolved methyllithium-containing composition for use in synthesis reactions.
Weiner David B. (Merion PA) Refaeli Yosef (Boston MA) Levy David N. (Birmingham AL), Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions.
Ottow Eckhard (Berlin DEX) Wiechert Rudolf (Berlin DEX) Neef Gunter (Berlin DEX) Beier Sybille (Berlin DEX) Elger Walter (Berlin DEX) Henderson David A. (Berlin DEX), Process for preparing 19,11b
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Ottow Eckhard (Berlin DEX) Schwede Wolfgang (Berlin DEX) Halfbrodt Wolfgang (Berlin DEX) Fritzemeier Karl-Heinrich (Berlin DEX) Krattenmacher Rolf (Berlin DEX), Progestationally active 19,11-bridged 4-estrenes.
Klar, Ulrich; Cleve, Arwed; Neef, Guenter; Ottow, Eckhard; Stoekemann, Klaus; Fritzemeier, Karl-Heinrich, Steroid esters and amides, process for their production and their pharmaceutical use.
Klar Ulrich,DEX ; Cleve Arwed,DEX ; Schwede Wolfgang,DEX ; Neef Gunter,DEX ; Ottow Eckhard,DEX ; Chwalisz Kristof,DEX ; Schneider Martin,DEX, Steroid esters, process for their production and their pharmaceutical use.
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