초록 ▼

Disclosed is a soluble, biocompatible, pharmacological agent for inhibiting thrombin generation and thrombus formation, and methods for producing the same. The pharmacological agent or conjugate includes a soluble, biocompatible carrier and a thrombogenesis inhibitor immobilized thereto via the carr

Disclosed is a soluble, biocompatible, pharmacological agent for inhibiting thrombin generation and thrombus formation, and methods for producing the same. The pharmacological agent or conjugate includes a soluble, biocompatible carrier and a thrombogenesis inhibitor immobilized thereto via the carrier which binds the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or active fragment thereof. The thrombogenesis inhibitor may be bound to the carrier via a bifunctional cross-linking reagent.

대표청구항 ▼

A soluble, biocompatible, pharmacological agent for inhibiting thrombin generation and thrombus formation comprising: (a) a soluble, biocompatible carrier “selected from the group consisting of a protein, peptide, lipoprotein, glycoprotein, glycosaminoglycan and mixtures thereof”; and (b) a thrombog

A soluble, biocompatible, pharmacological agent for inhibiting thrombin generation and thrombus formation comprising: (a) a soluble, biocompatible carrier “selected from the group consisting of a protein, peptide, lipoprotein, glycoprotein, glycosaminoglycan and mixtures thereof”; and (b) a thrombogenesis inhibitor covalently immobilized on said carrier, said inhibitor being hirudin or an active analog or active fragment thereof.