[특허]Controlled-volume assay apparatus

Controlled-volume assay apparatus 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12M-001/34 C12M-001/40 G01N-021/11
출원번호	US-0320474 (1989-03-08)
발명자 / 주소	Hewett Gary E. (Milpitas CA)
출원인 / 주소	Cholestech Corporation (Hayward CA 02)
인용정보	피인용 횟수 : 53 인용 특허 : 0

초록 ▼

Method and apparatus for use in determining the concentration of a selected analyte in a body-fluid sample. As the fluid sample is applied to a wettable, absorbent reaction pad, the extent of sample wetting of the pad is monitored by surface reflectance. This surface monitoring is used to control the volume of sample applied to the pad, to prevent overfilling the pad and to allow determination of the final sample volume applied. From the known sample volume and amount of analyte, the concentration of analyte in the sample can be accurately calculated in reaction components, trapping agents, matrix configuration, and analyte tested can be made.

대표청구항 ▼

A diagnostic apparatus for use in determining the concentration of a selected analyte in a body-fluid sample, comprising sample dispenser having (i) a support, (ii) a well defined in the support for receiving such sample, (iii) a fibrous filter matrix, (iv) capillary means for drawing sample fluid from said well into the matrix, and (v) an absorbent strip on said support having a central region in fluid contact with said matrix for distributing ample fluid from the matrix by capillary flow to sample-delivery sites in opposite end regions of the strip, a test plate carrying a plurality of wettable, absorbent pads, each having an exposed outer surface region and a defined expanse, said plurality of pads containing reagent means effective to produce a detectable analyte-dependent reaction product for detection of a selected analyte, when sample fluid is transferred from said sample-delivery sites to said plurality of pads, and means mounting said plate on said dispenser, said mounting means being adjacent to and spaced from said plurality of pads, for movement toward and away from a sample-delivery position at which substantially the entire outer exposed surface regions of said plurality of pads are in contact with the sample-delivery sites, for simultaneous transfer of substantially the same volume of sample fluid from each of said delivery sites to each of said pads in the support with fluid movement at a substantially uniform flow rate in a direction normal to the pad outer surface regions throughout the entire expanse of each of said pads, whereby said pads are filled uniformly to a selected volume when said pads are held in contact with said sample-delivery sites for a selected period of time, and control means operatively connected to said shifting means for placing said support at its sample-delivery position for such sample-delivery time.

이 특허를 인용한 특허 (53)

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Roth G. Thomas ; Paolini Gregory P., Blood fluid characteristics analysis instrument.
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Reynolds, Paul D.; Escutia, Raul; Larkin, John F.; Hu, Charles; Tomasco, Michael F.; Bloom, Daniel R.; Vivolo, Joseph A.; Wiard, Richard M., Devices and methods for body fluid sampling and analysis.
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Poto Edward M. ; Strahs Kenneth R. ; Conner Timothy J. ; Delahanty Francis T. ; Moorman Michael ; Wieck Henry, Disposable electronic diagnostic instrument.
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Poto Edward M. ; Strahs Kenneth R. ; Conner Timothy J. ; Delahanty Francis T. ; Moorman Michael ; Wieck Henry, Disposable electronic diagnostic instrument.
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Gilmour,Steven B.; Modzelewski,Brent E., Distinguishing test types through spectral analysis.
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Modzelewski, Brent E.; Gilmour, Steven B., Distinguishing test types through spectral analysis.
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Blatt, Joel M.; Allen, Michael P., Dry reagent particle assay and device having multiple test zones and method therefor.
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Sharrock,Stephen Paul; Phelan,Andrew Peter, Early determination of assay results.
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Allen Michael P. ; Blatt Joel M. ; Widunas Joseph T., Electronic assay device and method.
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Arab, Nicolas, Evaluation of focusing performance in an assay analysis system.
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Sharrock,Stephen P.; Phelan,Andrew P., Flow sensing for determination of assay results.
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Jones, Ronald M.; Worthy, Thomas E.; Nugent, Anthony J., High-density lipoprotein assay device and method.
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Jones, Ronald M.; Worthy, Thomas E.; Nugent, Anthony J., High-density lipoprotein assay device and method.
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Ramel, Urs A.; Tay, Dillan, Mechanical cartridge with test strip fluid control features for use in a fluid analyte meter.
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Wolfgang Petrich DE; Uwe Ruppender DE; Dirk Voelkel DE, Method and device for checking the liquid take up of a test layer of an analysis element.
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Carpenter, Charles, Method and device for detecting analytes in fluids.
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Carpenter, Charles R., Method and device for detecting analytes in fluids.
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Carpenter, Charles R., Method and device for detecting analytes in fluids.
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Blatt Joel M. ; Allen Michael P. ; Patel Paul J., Method and device producing a predetermined distribution of detectable change in assays.
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Modzelewski, Brent E.; Gilmour, Steven B.; Roth, G. Thomas; Bell, Douglas E., Method for determining concentration of an analyte in a test strip.
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Phillips, Roger; McGarraugh, Geoffery; Jurik, Franklin A.; Underwood, Raymond D., Method for the determination of glucose employing an apparatus emplaced matrix.
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Miltner, Karl; Ruppender, Uwe; Wersig, Christian; Zimmer, Volker, Method for the photometric analysis of test elements.
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Phillips Roger ; McGarraugh Geoffery ; Jurik Franklin A. ; Underwood Raymond D., Reflectance measurement of analyte concentration with automatic initiation of timing.
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Haar,Hans Peter; List,Hans, System, for monitoring the concentration of analytes in body fluids.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
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연합인증

Controlled-volume assay apparatus 원문보기

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이 특허를 인용한 특허 (53)

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