[특허]Multi-signal electrical transdermal drug applicator

Multi-signal electrical transdermal drug applicator 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61N-001/30
출원번호	US-0349996 (1989-05-10)
발명자 / 주소	Sibalis Dan (Stony Brook NY)
출원인 / 주소	Drug Delivery Systems Inc. (New York NY 02)
인용정보	피인용 횟수 : 78 인용 특허 : 0

초록 ▼

A transdermal application for attachment to the skin having at least one drug reservoir containing at least one drug, and having an electrical connection formed at a surface interface between said reservoir upon contact with said skin; means for causing said at least one drug to move through said interface transdermally and for maintaining said transdermal movement for an extended time period. The means for causing and maintaining transdermal movement including a source of varying electrical potential, said source having one terminal electrically connected to said at least one reservoir at a location away from said skin surface interface and an other terminal in circuit with said skin surface at a location away from said reservoir/skin surface interface. The electrical circuit is formed upon application to the skin of the device, and said circuit connecting from said one source terminal through said at least one reservoir, through said reservoir/skin surface interface, within said skin to said skin surface connected in circuit to said other source terminal, wherein the drug is delivered through said skin when electrical current flows in a first direction in the circuit. The varying electrical potential is the resultant combination by at least one of superposition and selection of a plurality of electrical signals, and the electrical source including at least one of means for storing data representative of said resultant and means for generating the plurality of signals, and means for selecting and superposing the signals in selected time relationships for application to the source terminals.

대표청구항 ▼

A transdermal applicator for delivering at least one drug through the skin to the blood circulation system of a patient over an extended period of time comprising: a drug reservoir for containing at least one drug and having means for attachment to the skin of a patient and making an electrical connection therewith at an interface between the reservoir and the skin of the patient, means connected to said reservoir including a source of variable electrical potential for effecting delivery of said drug transdermally into the blood of the patient when the applicator is in use, said source having one electrical terminal electrically connected to said reservoir spaced from said interface and a second terminal positionable on the surface of the skin of the patient spaced from said interface and in circuit with said interface when said applicator is in use, means in said source of variable electrical potential for cyclically generating a complex composite pulse signal applied to said one terminal, said reservoir and through said interface when said second terminal is in electrical contact with the skin of the patient, said complex composite pulse signal comprising a conditioning negative directcurrent leading pulse followed by a sequence of pulses direct current pulses of different waveforms, amplitudes, frequencies and repetition rates, and timing means for applying the complex composite pulse signal as a composite total waveform signal with selected sequencies of different time intervals of waveform components effective to develop and maintain current flow including current flow within blood capillaries of the patient in the same direction of current flow as the leading direct current pulse of the complex composite pulse signal.

이 특허를 인용한 특허 (78)

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Yanaki, Jamal S., Active transdermal medicament patch and circuit board for same.
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Sun, Ying; Oakeson, Ralph W.; Wisniewski, Stephen J.; Wang, Jonas C. T., Exothermic topical delivery device.
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Andreas, Bernard H.; Girotra, Rohit; Walker, Jeffrey A.; Gross, T. Daniel; Clopp, Mathew D.; Kermani, Mahyar Z.; Baron, Scott J., Features to improve and sense tympanic membrane apposition by tympanostomy tube delivery instrument.
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Henley, Julian L.; Chang, Kuo Wei; Potter, Joseph; Goldberg, Dennis I., Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor.
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Zhang Lei ; Hofmann Gunter A., Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications.
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Zhang, Lei; Hofmann, Gunter A., Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications.
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Andreas, Bernard H.; Saleki, Mansour; Girotra, Rohit; Cantu, Alfredo; Bhat, Nikhil, Personalizable system and method for anesthetizing the tympanic membrane.
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Shahoian, Erik J., System and method for the simultaneous automated bilateral delivery of pressure equalization tubes.
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Girotra, Rohit; Gross, Thomas D., Trigger assembly for tympanostomy tube delivery device.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
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연합인증

Multi-signal electrical transdermal drug applicator 원문보기

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이 특허를 인용한 특허 (78)

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Multi-signal electrical transdermal drug applicator 원문보기

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연구과제 타임라인

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이 특허를 인용한 특허 (78)

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